| 1. |
2024
Hsieh YY,Du JL,Yang PM.
Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer and overcoming drug resistance
. Molecular Oncology
.2024
;(18):386-414
|
|
| 2. |
2024
Wu TH,Lin TY,Yang PM,Li WT,Yeh CT,Pan TL.
Scutellaria baicalensis induces cell apoptosis and elicits mesenchymal-epithelial transition to alleviate metastatic hepatocellular carcinoma via modulating HSP90β
. International Journal of Molecular Sciences
.2024
;(25):3073
|
|
| 3. |
2024
Chan TS,Cheng LH,Hsu CC,Yang PM,Liao TY,Hsieh HY, Lin PC, HuangFu WC, Chuu CP, Tsai KK.
ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells
. Molecular Oncology
.2024
;(18):562-579
|
|
| 4. |
2023
Cheng LH,Hsu CC,Tsai HW,Liao WY,Yang PM,Liao TY, Hsieh HY, Chan TS, Tsai KK.
ASPM activates Hedgehog and Wnt signaling to promote small cell lung cancer stemness and progression
. Cancer Research
.2023
;(83):830-844
|
|
| 5. |
2023
Lin JC,Liu TP,Chen YB,Huang TS,Chen TY,Yang PM.
Inhibition of CDK9 exhibits anticancer activity in hepatocellular carcinoma cells via targeting ribonucleotide reductase
. Toxicology and Applied Pharmacology
.2023
;(471):116568-116568
|
|
| 6. |
2023
Lin JC,Liu TP,Chen YB,Yang PM.
PF-429242 exhibits anticancer activity in hepatocellular carcinoma cells via FOXO1-dependent autophagic cell death and IGFBP1-dependent anti-survival signaling
. American Journal of Cancer Research
.2023
;(13):4125-4144
|
|
| 7. |
2022
Wang PW,Lin TY,Yang PM,Fang JY,Li WT,Pan TL.
Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis-like lesions via regulating the responses of keratinocyte and macrophage
. Biomedicine & Pharmacotherapy
.2022
;(155):113798-113798
|
|
| 8. |
2022
Chou Pei Hsuan,Luo Cong Kai,Wali Niaz,Lin Wen Yen,Ng Shang Kok,Wang Chun Hao,Zhao Mingtao,Lin Sheng Wei,Yang Pei Ming,Liu Pin Jung,Shie Jiun Jie,Wei Tzu Tang,Chou Pei Hsuan,Luo Cong Kai,Wali Niaz,Lin Wen Yen,Ng Shang Kok,Wang Chun Hao,Zhao Mingtao,Lin Sheng Wei,Yang Pei Ming,Liu Pin Jung,Shie Jiun Jie,Wei Tzu Tang.
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer
. Journal of Biomedical Science
.2022
;(29):20-20
|
|
| 9. |
2022
Wang Pei Wen,Lin Tung Yi,Yang Pei Ming,Yeh Chau Ting,Pan Tai Long,Wang Pei Wen,Lin Tung Yi,Yang Pei Ming,Yeh Chau Ting,Pan Tai Long.
Hepatic Stellate Cell Modulates the Immune Microenvironment in the Progression of Hepatocellular Carcinoma
. International Journal of Molecular Sciences
.2022
;(23):10777-10777
|
|
| 10. |
2022
Ko Ching Chung,Hsieh Yao Yu,Yang Pei Ming.
Long Non-Coding RNA MIR31HG Promotes the Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma Cells
. International Journal of Molecular Sciences
.2022
;(23):6559-6559
|
|
| 11. |
2022
Hsieh Yao Yu,Cheng Ya Wen,Wei Po Li,Yang Pei Ming.
Repurposing of ingenol mebutate for treating human colorectal cancer by targeting S100 calcium-binding protein A4 (S100A4)
. Toxicology and Applied Pharmacology
.2022
;(449):116134-116134
|
|
| 12. |
2021
Wang SJ,Yang PM.
A bioinformatics analysis identifies the telomerase inhibitor MST-312 for treating high-STMN1-expressing hepatocellular carcinoma.
. Journal of Personalized Medicine
.2021
;(11):332-332
|
|
| 13. |
2021
Lin JC,Yang PM,Liu TP.
PERK/ATF4-dependent ZFAS1 upregulation is associated with sorafenib resistance in hepatocellular carcinoma cells.
. International Journal of Molecular Sciences
.2021
;(22):5848-5848
|
|
| 14. |
2021
Wu TH,Wang PW,Lin TY,Yang PM,Li WT,Yeh CT, Pan TL.
Antioxidant properties of red raspberry extract alleviate hepatic fibrosis via inducing apoptosis and transdifferentiation of activated hepatic stellate cells.
. Biomedicine & Pharmacotherapy
.2021
;(144):112284-112284
|
|
| 15. |
2021
Huang SS,Liao WY,Hsu CC,Chan TS,Liao TY,Yang PM, Chen LT, Sung SY, Tsai KK.
A novel invadopodia-specific marker for invasive and pro-metastatic cancer stem cells.
. Frontiers in Oncology
.2021
;(11):638311-638311
|
|
| 16. |
2021
Lin JC,Liu TP,Andriani V,Athoillah M,Wang CY,Yang PM.
Bioinformatics analysis identifies precision treatment with paclitaxel for hepatocellular carcinoma patients harboring mutant TP53 or wild-type CTNNB1 gene
. Journal of Personalized Medicine
.2021
;(11):1199-1199
|
|
| 17. |
2020
Yang PM,Lin LS,Liu TP.
Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells.
. Biomolecules
.2020
;(10):117-117
|
|
| 18. |
2020
Chen CH,Hsieh YC,Yang PM,Liu YR,Cho EC.
Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer.
. Biochemical and Biophysical Research Communications
.2020
;(524):1003-1009
|
|
| 19. |
2020
Yang PM,Hsieh YY,Du JL,Yen SC,Hung CF.
Sequential interferon β-cisplatin treatment enhances the surface exposure of calreticulin in cancer cells via an interferon regulatory factor 1-dependent manner.
. Biomolecules
.2020
;(10):643
|
|
| 20. |
2020
Li A,Yang PM.
Overexpression of miR-21-5p in colorectal cancer cells promotes self-assembly of E-cadherin-dependent multicellular tumor spheroids.
. Tissue and Cell
.2020
;(65):101365
|
|
| 21. |
2020
Liu LW,Hsieh YY,Yang PM.
Bioinformatics data mining repurposes the JAK2 (Janus Kinase 2) inhibitor fedratinib for treating pancreatic ductal adenocarcinoma by reversing the KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-driven gene signature
. Journal of Personalized Medicine
.2020
;(10):130
|
|
| 22. |
2020
Hung YC,Wang PW,Lin TY,Yang PM,You JS,Pan TL.
Functional redox proteomics reveals that Salvia miltiorrhiza aqueous extract alleviates adriamycin-induced cardiomyopathy via inhibiting ROS dependent apoptosis
. Oxidative Medicine and Cellular Longevity
.2020
;(2020):5136934
|
|
| 23. |
2020
Lin TY,Wang PW,Huang CH,Yang PM,Pan TL.
Characterizing the relapse potential in different luminal subtypes of breast cancers with functional proteomics
. International Journal of Molecular Sciences
.2020
;(21):6077
|
|
| 24. |
2020
Lin JC,Liu TP,Yang PM.
CDKN2A-inactivated pancreatic ductal adenocarcinoma exhibits therapeutic sensitivity to paclitaxel: a bioinformatics study
. Journal of Clinical Medicine
.2020
;(9):4019
|
|
| 25. |
2019
Hsieh YY,Liu TP,Yang PM.
In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma
. Pathology-Research and Practice
.2019
;(215):152373
|
|
| 26. |
2019
Chen JC,Hsieh YY,Lo HL,Li A,Chou CJ,Yang PM.
In vitro and in silico mechanistic insights into miR-21-5p-mediated topoisomerase drug resistance in human colorectal cancer cells
. Biomolecules
.2019
;(9):467
|
|
| 27. |
2019
Wang PW,Lin TY,Hung YC,Chang WN,Yang PM,Chen MH, Yeh CT, Pan TL.
Characterization of fibrinogen as a key modulator in patients with Wilson's diseases with functional proteomic tools
. International Journal of Molecular Sciences
.2019
;(20):4528
|
|
| 28. |
2019
Hsieh YY,Liu TP,Chou CJ,Chen HY,Lee KH,Yang PM.
Integration of bioinformatics resources reveals the therapeutic benefits of gemcitabine and cell cycle intervention in SMAD4-deleted pancreatic ductal adenocarcinoma
. Genes (Basel)
.2019
;(10):766
|
|
| 29. |
2019
Leung SW,Chou CJ,Huang TC,Yang PM.
An integrated bioinformatics analysis repurposes an antihelminthic drug niclosamide for treating HMGA2-overexpressing human colorectal cancer
. Cancers (Basel)
.2019
;(11):1482
|
|
| 30. |
2019
Yang PM,Hong YH,Hsu KC,Liu TP.
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma
. American Journal of Cancer Research
.2019
;(9):2120-2139
|
|
| 31. |
2019
Huang YM,Cheng CH,Pan SL,Yang PM,Lin DY,Lee KH.
Gene expression signature-based approach identifies antifungal drug ciclopirox as a novel inhibitor of HMGA2 in colorectal cancer.
. Biomolecules
.2019
;(9):688
|
|
| 32. |
2019
Chen GW,Chen TY,Yang PM.
Differential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes
. Drug and Chemical Toxicology
.2019
|
|
| 33. |
2019
Wang PW,Hung YC,Lin TY,Fang JY,Yang PM,Chen MH, Pan TL.
Comparison of the biological impact of UVA and UVB upon the skin with functional proteomics and immunohistochemistry.
. Antioxidants
.2019
;(8):E569
|
|
| 34. |
2018
Cheng YW ,Chou CJ ,Yang PM .
Ten-eleven translocation 1 (TET1) gene is a potential target of miR-21-5p in human colorectal cancer
. Surgical Oncology
.2018
;(27):76-81
|
|
| 35. |
2018
Liu TP,Hsieh YY,Chou CJ,Yang PM.
Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining
. Royal Society Open Science
.2018
;(5):181321-181321
|
|
| 36. |
2017
Liu TP,Hong YH,Yang PM.
In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells
. Oncotarget
.2017
;(8):86168-86180
|
|
| 37. |
2017
Yang PM,Du JL,Chia JS,Wang GN,Hsu WB,Pu PC, Sun A, Chiang CP, Wang WB.
The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell-Vaccinated Mice
. Integrative Cancer Therapies
.2017
;(16):319-328
|
|
| 38. |
2017
Yang PM,Hung CF.
Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma
. Oncotarget
.2017
;(8):46145-46162
|
|
| 39. |
2016
Hsieh YY,Lo HL,Yang PM.
EZH2 inhibitors transcriptionally upregulate cytotoxic autophagy and cytoprotective unfolded protein response in human colorectal cancer cells
. American Journal of Cancer Research
.2016
;(6):1661-1680
|
|
| 40. |
2016
Liu TP,Hong YH,Tung KY,Yang PM.
In silico and experimental analyses predict the therapeutic value of an EZH2 inhibitor GSK343 against hepatocellular carcinoma through the induction of metallothionein genes.
. Oncoscience
.2016
;(3):9-20
|
|
| 41. |
2016
Kao CY,Yang PM,Wu MH,Huang CC,Lee YC,Lee KH.
Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells
. PeerJ
.2016
;(4):e1683-e1683
|
|
| 42. |
2016
Hsieh YY,Huang TC,Lo HL,Jhan JY,Chen ST,Yang PM.
Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine
. Oncotarget
.2016
;(7):1-16
|
|
| 43. |
2016
Hsieh YY,Chou CJ,Lo HL,Yang PM.
Repositioning of a cyclin-dependent kinase inhibitor GW8510 as a ribonucleotide reductase M2 inhibitor to treat human colorectal cancer
. Cell Death Discovery
.2016
;(2):16027-16027
|
|
| 44. |
2015
Liu TP,Lo HL,Wei LS,Hsiao HH,Yang PM.
S-adenosyl methionine (SAM)-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells
. Anti-Cancer Drugs
.2015
;(26):139-147
|
|
| 45. |
2015
Liu CH,Tang WC,Sia P,Huang CC,Yang PM,Wu MH, Lai IL, Lee KH.
Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance.
. International Journal of Medical Sciences
.2015
;(12):63-71
|
|
| 46. |
2015
Liu TP,Yang PM.
Autophagic effect of SAM-competitive EZH2 inhibitors on cancer cells.
. Cancer Cell & Microenvironment (Research Highlight)
.2015
;(2):e551-e551
|
|
| 47. |
2015
Nana AW,Yang PM,Lin HY.
Overview of transforming growth factor β superfamily involvement in glioblastoma initiation and progression.
. Asian Pacific Journal of Cancer Prevention
.2015
;(16):6813-6823
|
|
| 48. |
2014
Lee KH,Lo HL,Tang WC,Hsiao HH,Yang PM.
A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
. Scientific Reports
.2014
;(4):6394-6394
|
|
| 49. |
2014
Huang YH#,Yang PM#,Chuah QY,Lee YJ,Hsieh YF,Peng CW, Chiu SJ (#Equal contribution).
Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells
. Autophagy
.2014
;(10):1212-1228
|
|
| 50. |
2014
Tsai CT,Yang PM,Chern TR,Chuang SH,Lin JH,Klemm L, Müschen M, Chen CC.
AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine
. Oncotarget
.2014
;(5):211-223
|
|
| 51. |
2014
Liao EC,Hsu YT,Chuah QY,Lee YJ,Hu JY,Huang TC, Yang PM*, Chiu SJ*.
Radiation induces senescence and a bystander effect through metabolic alterations
. Cell Death & Disease
.2014
;(5):e1255-e1255
|
|
| 52. |
2013
Yu YC#,Yang PM#,Chuah QY,Huang YH,Peng CW,Lee YJ, Chiu SJ (#Equal contribution).
Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways
. Scientific Reports
.2013
;(3):1675-1675
|
|
| 53. |
2013
Yang PM#,Lin YT#,Shun CT,Lin SH,Wei TT,Chuang SH, Wu MS, Chen CC(#Equal contribution).
Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.
. Scientific Reports
.2013
;(3):3219-3219
|
|
| 54. |
2013
Yu PH,Chou SF,Chen CL,Hung H,Lai CY,Yang PM, Jeng YM, Liaw SF, Kuo HH, Hsu HC, Chen JY, Wang WB.
Upregulation of endocan by epstein-barr virus latent membrane protein 1 and its clinical significance in nasopharyngeal carcinoma.
. PLoS One
.2013
;(8):e82254-e82254
|
|
| 55. |
2012
Yang PM,Lin PJ,Chen CC.
CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1
. Epigenetics
.2012
;(7):390-399
|
|
| 56. |
2012
Tseng HH,Chuah QY,Yang PM,Chen CT,Chao JC,Lin MD, Chiu SJ.
Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells
. PLoS One
.2012
;(7):e36006-e36006
|
|
| 57. |
2012
Yang PM,Tseng HH,Peng CW,Chen WS,Chiu SJ.
Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy
. International Journal of Oncology
.2012
;(40):469-478
|
|
| 58. |
2011
Yu SH,Yang PM,Peng CW,Yu YC,Chiu SJ.
Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis
. Cancer Letters
.2011
;(300):96-104
|
|
| 59. |
2011
Yang PM,Chen CC.
Life or death? Autophagy in anticancer therapies with statins and histone deacetylase inhibitors
. Autophagy (Research Highlight)
.2011
;(7):107-108
|
|
| 60. |
2011
Huang WY,Yang PM,Chang YF,Marquez VE,Chen CC.
Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2
. Biochemical Pharmacology
.2011
;(81):510-517
|
|
| 61. |
2010
Yang PM#,Huang WC#,Lin YC#,Huang WY,Wu HA,Chen WL, Chang YF, Chou CW, Tzeng CC, Chen YL, Chen CC (#Equal contribution).
Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis
. Journal of Cellular and Molecular Medicine
.2010
;(14):687-698
|
|
| 62. |
2010
Yang PM#,Liu YL#,Lin YC#,Shun CT,Wu MS,Chen CC (#Equal contribution).
Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies
. Cancer Research
.2010
;(70):7699-7709
|
|
| 63. |
2010
Yang PM,Lin JH,Huang WY,Lin YC,Yeh SH,Chen CC.
Inhibition of histone deacetylase activity is a novel function of the antifolate drug methotrexate
. Biochemical and Biophysical Research Communications
.2010
;(391):1396-1399
|
|
| 64. |
2010
Liu YL#,Yang PM#,Shun CT,Wu MS,Weng JR,Chen CC (#Equal contribution).
Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma
. Autophagy
.2010
;(6):1057-1065
|
|
| 65. |
2009
Hsu TS#,Yang PM#,Tsai JS,Lin LY,(#Equal contribution).
Attenuation of cadmium-induced necrotic cell death by necrostatin-1: potential necrostatin-1 acting sites
. Toxicology and Applied Pharmacology
.2009
;(235):153-162
|
|
| 66. |
2009
Lin MH,Hsu TS,Yang PM,Tsai MY,Perng TP,Lin LY.
Comparison of organic and inorganic germanium compounds in cellular radiosensitivity and preparation of germanium nanoparticles as a radiosensitizer
. International Journal of Radiation Biology
.2009
;(85):214-226
|
|
| 67. |
2007
Yang PM,Chen HC,Tsai JS,Lin LY.
Cadmium induces Ca2+-dependent necrotic cell death through calpain-triggered mitochondrial depolarization and reactive oxygen species-mediated inhibition of nuclear factor-kappaB activity
. Chemical Research in Toxicology
.2007
;(20):406-415
|
|
| 68. |
2005
Yang PM,Chiu SJ,Lin LY.
Differential effects of salen and manganese-salen complex (EUK-8) on the regulation of cellular cadmium uptake and toxicity
. Toxicological Sciences
.2005
;(85):551-559
|
|
| 69. |
2004
Yang PM,Chiu SJ,Lin KA,Lin LY.
Effect of cadmium on cell cycle progression in Chinese hamster ovary cells
. Chemico-Biological Interactions
.2004
;(149):125-136
|
|