鄭柏青(Cheng, Po-Ching) 教授

Email
bonjovi@tmu.edu.tw
現   職
分子寄生蟲暨熱帶疾病學科 主任
分子寄生蟲暨熱帶疾病學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立陽明大學熱帶醫學研究所 博士
2001/09~2008/08
中山大學生物科學所 碩士
1999/09~2001/06
中山大學生物科學系 學士
1995/09~1999/06

本校學術經歷

任職單位與職稱[起迄時間]
分子寄生蟲暨熱帶疾病學科教授
2024/02/01~
分子寄生蟲暨熱帶疾病學科副教授
2018/02/01~2024/01/31
分子寄生蟲暨熱帶疾病學科助理教授
2014/08/01~2018/01/31
寄生蟲學科助理教授
2012/10/01~2014/07/31
寄生蟲學科助理研究員
2012/08/31~2012/09/30

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
分子寄生蟲暨熱帶疾病學科主任
2020/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
核能研究所副工程師
2011/08/16~2012/08/30
核能研究所副研發師
2008/09/08~2011/06/23

專長與研究領域

學門領域
寄生蟲學、醫事技術及實驗診斷
微生物及免疫學
放射線及核子醫學
中醫藥
學術專長
感染免疫學
感染免疫學
寄生蟲學
寄生蟲學
免疫療法及疫苗發展
免疫療法及疫苗發展
寄生蟲分子免疫學
寄生蟲分子免疫學
熱帶醫學
熱帶醫學

論文著作

清冊下載


1. 2024 Chang KW,Wang LC,Wang HY,Lin TY,En-Te Hwu E,Cheng PC. Inflammatory and immunopathological differences in brains of permissive and non-permissive hosts with Angiostrongylus cantonensis infection can be identified using 18F/FDG/PET-imaging . PLOS Neglected Tropical Diseases .2024 ;(18):12188-1210

2. 2024 Chen YC,Lee YL,Lee CA,Lin TY,Hwu EE,Cheng PC. Development of a Lipid-encapsulated TGFβRI-siRNA Drug for Liver Fibrosis Induced by Schistosoma mansoni . PLoS Negl Trop Dis .2024 ;(18):e0012502

3. 2024 Chuang HC,Chuang KJ,Cheng PC,Hsieh CL,Fan YY,Lee YL. Indirubin induces tolerogenic dendritic cells via aryl hydrocarbon receptor activation and ameliorates allergic asthma in a murine model by expanding Foxp3-expressing regulatory T cells . Phytomedicine .2024 ;(135):156013

4. 2023 Chen YC,Chen IA,Peng SY,Cheng PC. Differential Analysis of Key Proteins Related to Fibrosis and Inflammation in Soluble Egg Antigen of Schistosoma mansoni at Different Infection Times . Pathogens .2023 ;(12):441-459

5. 2023 Lee CY,Liao CW,Wang LC,Fan CK,Chuang TW,En-Te Hwu E, Chao D, Cheng PC.. IgE antibody responses in cerebrospinal fluids relate to the brain pathologic injury of hosts with Angiostrongylus cantonensis infection . Journal of Microbiology, Immunology and Infection .2023 ;(S1684-1182(23)):00163-9

6. 2022 Hsiao TC,Cheng PC,Chi KH,Wang HY,Pan SY,Kao C, Lee YL, Kuo HP, Chung KF, Chuang HC. Interactions of chemical components in ambient PM2.5 with influenza viruses . Journal of Hazardous Materials .2022 ;(423):127243-127252

7. 2022 Leung SW, ,Cheng PC, ,Chou CM, ,Lin C, ,Kuo YC, ,Lee YL, Liu CY, Mi FL, Cheng CH. . A novel low-molecular-weight chitosan/gamma-polyglutamic acid polyplexes for nucleic acid delivery into zebrafish larvae. . International Journal of Biological Macromolecules. .2022 ;(194):384-389

8. 2022 Lam HYP,Cheng PC,Peng SY. Resolution of systemic complications in S. mansoni infected mice by concomitant treatment with praziquantel and Schisandrin B. . International Journal for Parasitology .2022 ;(52):275-284

9. 2022 Lam HYP,,Tseng YC,,Wu WJ,,Yu YH, ,Cheng PC, ,Peng SY.. Prevalence and genotypes of Cryptosporidium in livestock in Hualien Country, Eastern Taiwan . Parasitology International .2022 ;(88):102553

10. 2022 Ho CH,Liao PW,Fan CK,Liu SP,Cheng PC. RNase7 inhibits uropathogenic Escherichia coli-induced in-flammation in bladder cells under high-glucose environment by regulating JAK/STAT signaling pathway . International Journal of Molecular Sciences .2022 ;(23):5156-5162

11. 2022 Pekkle Lam HY,Hung MY,Cheng PC,Peng SY. Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis . Journal of Microbiology, Immunology and Infection .2022 ;(55):757-765

12. 2022 Zulfa R,Lo WC,Cheng PC,Martini M,Chuang TW.. Updating the Insecticide Resistance Status of Aedes aegypti and Aedes albopictus in Asia: A Systematic Review and Meta-Analysis . Tropical Medicine and Infectious Disease .2022 ;(7):306-323

13. 2022 Chen PC,Ho CH,Fan CK,Liu SP,Cheng PC.. Antimicrobial Peptide LCN2 Inhibited Uropathogenic Escherichia coli Infection in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway . International Journal of Molecular Sciences .2022 ;(23):15763-15781

14. 2022 Lin MH,Cheng PC,Hsiao PJ,Chen SC,Hung CH,Kuo CH, Huang SK, Clair Chiou HY.. The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4 . International Immunopharmacology .2022 ;(115):109653-10.1016/j.intimp.2022.109663

15. 2021 Kang-Yun Lee,Yi-Lin Lee,Ming-Hsiu Chiang,Hung-Yang Wang,Chong-Yu Chen,Chang-Hong Lin, Ying-Chou Chen, Chia-Kwung Fan, Po-Ching Cheng . Schistosoma egg antigens suppress LPS-induced inflammation in human IMR-90 cells by modulation of JAK/STAT1 signaling . Journal of Microbiology, Immunology and Infection .2021 ;(54):501-513

16. 2021 Ho CH,Fan CK,Wu CC,Yu HJ,Liu HT,Chen KC, Liu SP, Cheng PC. Enhanced uropathogenic Escherichia coli-induced infection in uroepithelial cells by sugar through TLR-4 and JAK/STAT1 signaling pathways . Journal of Microbiology, Immunology and Infection .2021 ;(54):193-205

17. 2021 Chen-Hsun Ho,Chia-Hsiung Cheng,Tzu-Wen Huang,Shih-Yi Peng,Kin-Mu Lee,Po-Ching Cheng. Switched phenotypes of macrophages during the different stages of Schistosoma japonicum infection influenced the subsequent trends of immune responses . Journal of Microbiology, Immunology and Infection .2021 ;(55):503-526

18. 2021 Lam HYP,Liang TR,Lan YC,Chang KC,Cheng PC,Peng SY. Antifibrotic and anthelminthic effect of casticin on Schistosoma mansoni-infected BALB/c mice . Journal of Microbiology, Immunology and Infection .2021

19. 2021 Lam HYP,Yang TH,Liang TR,Cheng PC,Chang KC,Peng SY. Heat-killed Propionibacterium acnes augment the protective effect of 28-kDa glutathione S-transferases antigen against Schistosoma mansoni infection . Acta Tropica .2021 ;(222):106033-106042

20. 2021 Lam HYP,Huang SP,Liang TR,Wu WJ,Cheng PC,Chang KC, Peng SY.. Increased immunogenicity and protection of recombinant Sm14 antigens by heat-killed Cutibacterium acnes in BALB/c mice infected with Schistosoma mansoni. . Parasitology International .2021 ;(86):102446

21. 2021 Ho CH,Liu SP,Fan CK,Tzou KY,Wu CC,Cheng PC. Insulin downregulated the infection of uropathogenic Esche-richia coli (UPEC) in bladder cells in a high-glucose environ-ment through JAK/STAT signaling pathway . microorganisms .2021 ;(9):2421-2439

22. 2020 Ho Yin Pekkle Lam,Tina Tu-Wen Chen,Cheng-Chi Chen,Ting-Hua Yang,Po-Ching Cheng,Shih-Yi Peng. Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice. . Parasitology International .2020 ;(77):102119

23. 2020 Ho CH,Lu YC,Fan CK,Yu HJ,Liu HT,Wu CC, Chen KC, Liu SP, Cheng PC. Testosterone regulates the intracellular bacterial community formation of uropathogenic Escherichia coli in prostate cells via STAT3 . International Journal of Medical Microbiology .2020 ;(310):151450

24. 2020 Hanh NTL,Lee YL,Lin CL,Chou CM,Cheng PC,Quang HH, Fan CK. Evidence for Asthma in the Lungs of Mice Inoculated with Different Doses of Toxocara canis . The American Journal of Tropical Medicine and Hygiene .2020

25. 2020 Tung NT,Cheng PC,Chi KH,Hsiao TC,Jones T,BéruBé K, Ho KF, Chuang HC.. Particulate matter and SARS-CoV-2: A possible model of COVID-19 transmission . Science of The Total Environment .2020 ;(750):141532

26. 2020 Lam HYP,Chen CC,Chen TT,Chang KC,Wu WJ,Yang TH, Liang TR, Cheng PC, Peng SY.. Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain . Parasitology International .2020 ;(80):102231

27. 2019 Chen TTW,Cheng PC,Chang KC,Cao JP,Feng JL,Chen CC, Lam HYP, Peng SY. Activation of the NLRP3 and AIM2 inflammasomes in a mouse model of Schistosoma mansoni infection . Journal of Helminthology .2019 ;(94):72

28. 2019 Lee CY,Cheng PC,Ho CH,Fan CK,Chao D. Immunologic evaluation of extracted intestinal proteins from Angiostrongylus cantonensis adult worms . Journal of Microbiology, Immunology and Infection .2019 ;(52):620-629

29. 2019 Gyang VP,Chuang TW,Liao CW,Lee YL,Akinwale OP,Orok A, Ajibaye O, Babasola AJ, Cheng PC, Chou CM, Huang YC, Sonko P, Fan CK.. Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria. . J Microbiol Immunol Infect. .2019 ;(52):106-113

30. 2019 Liao CW,Cheng PC,Chuang TW,Chiu KC,Chiang IC,Kuo JH, Tu YH, Fan YM, Jiang HT, Fan CK. Prevalence of Pediculus capitis in schoolchildren in Battambang, Cambodia. . Journal of Microbiology, Immunology and Infection .2019 ;(52):585-591

31. 2019 Lin MH ,Lee KM,Hsu CY,Peng SY,Lin CN,Chen CC, Fan CK, Cheng PC. Immunopathological effects of Agaricus blazei Murill polysaccharides against Schistosoma mansoni infection by Th1 and NK1 cells differentiation. . International Immunopharmacology .2019 ;(73):502-514

32. 2017 Ho CH,Fan CK,Yu HJ,Wu CC,Chen KC,Liu SP, Cheng PC. Testosterone suppresses uropathogenic Escherichia coli invasion and colonization within prostate cells and inhibits inflammatory responses through JAK/STAT-1 signaling pathway . PLOS one .2017 ;(12):1-19

33. 2017 Liao CW,Chiu KC,Chiang IC,Cheng PC,Chuang TW,Kuo JH, Tu YH, Fan CK. Prevalence and Risk Factors for Intestinal Parasitic Infection in Schoolchildren in Battambang, Cambodia. . Am J Trop Med Hyg. .2017 ;(96):583-588

34. 2017 Peng J,He ZP,Zhang S,Lun ZR,Wu ZD,Fan CK, Brown CL, Cheng PC, Peng SY, Yang TB.. Phylogeography of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae) in southern China and some surrounding areas. . PLoS Negl Trop Dis .2017

35. 2016 Cheng PC,Lin CN,Peng SY,Kang TF,Lee KM. Combined IL-12 Plasmid and Recombinant SjGST Enhance the Protective and Anti-pathology Effect of SjGST DNA Vaccine Against Schistosoma japonicum . PLOS Neglected Tropical Diseases .2016 ;(10):4459-4478

36. 2015 Dlamini SV,Liao CW,Dlamini ZH,Sipheph JS,Cheng PC,Chuang TW, Fan CK. Knowledge of human social and behavioral factors essential for the success of community malaria control intervention programs: The case of Lomahasha in Swaziland. . Journal of Microbiology, Immunology and Infection .2015

37. 2015 Gyang PV,Akinwale OP,Lee YL,Chuang TW,Orok AB,Ajibaye O, Liao CW, Chen PC, Chou CM, Huang YC, Barghouth U, Fan CK. Seroprevalence, disease awareness, and risk factors for Toxocara canis infection among primary schoolchildren in Makoko, an urban slum community in Nigeria . Acta Tropica .2015 ;(146):135-140

38. 2015 Lee YL,Cheng CY,Chang TT,Cheng PC,Yun HH,Lee KM. Evaluation of Antrodia Cinnamomea Extract MMH01 Effect on IMR-32 Neural Cells Activity . Journal of Testing and Quality Assurance .2015 ;(4):136-146

39. 2015 Luo TY,Cheng PC,Chiang PF,Chuang TW,Yeh CH,Lin WJ. 188Re-HYNIC-trastuzumab enhances the effect of apoptosis induced by trastuzumab in HER2-overexpressing breast cancer cells . Annals of Nuclear Medicine .2015 ;(29):52-62

40. 2015 Chen TT,Wu LS,Hsu PW,Pang CY,Lee KM,Cheng PC, Peng SY.. Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni . Acta Tropica .2015 ;(148):13-23

41. 2015 Gyang VP,Akinwale OP,Lee YL,Chuang TW,Orok A,Ajibaye O, Liao CW, Cheng PC, Chou CM, Huang YC, Fan KH, Fan CK. Toxoplasma gondii infection: seroprevalence and associated risk factors among primary schoolchildren in Lagos City, Southern Nigeria. . Revista da Sociedade Brasileira de Medicina Tropical .2015 ;(48):56-63

42. 2014 Yueh-Ting Tsai,Po-Ching Cheng,Tzu-Ming Pan. Anti-obesity effects of gut microbiota are associated with lactic acid bacteria . Applied Microbiology and Biotechnology .2014 ;(98):1-10

43. 2014 Cheng PC,Huang CC,Chiang PF,Lin CN,Li LL,Lee TW, Lin B, Chen IC, Chang KW, Fan CK, Luo TY. Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells . International Journal of Radiation Biology .2014 ;(90):841-852

44. 2014 Peir-Fen Guo,Tina Tu-Wen Chen,John Chin Tsaihong,Gen-der Ho,Po-ching Cheng,Yu-chuan Tseng, Shih-yi Peng. PREVALENCE AND SPECIES IDENTIFICATION OF CRYPTOSPORIDIUM FROM FECAL SAMPLES OF HORSES IN TAIWAN . The Southeast Asian Journal of Tropical Medicine and Public Health .2014 ;(45):6-12

45. 2014 Tseng YC,Ho GD,Chen T TW,Huang BF,Cheng PC,Chen JL, Peng SY. Prevalence and genotype of Giardia duodenalis from faecal samples of stray dogs in Hualien city of eastern Taiwan. . Tropical Biomedicine .2014 ;(31):305-311

46. 2013 Cheng PC,Chiang PF,Lee KM,Yeh CH,Hsu KL,Liu SW, Shen LH, Peng CL, Fan CK, Luo TY. Evaluating the potential of a new isotope-labeled glyco-ligand for estimating the remnant liver function of schistosoma-infected mice . Parasite Immunology .2013 ;(35):129-139

47. 2013 Cheng JR,Lin CN,Peng SY,Li LL,Lou TY,Fan CK, Lee KM. A study of immunomodulatory genes responses to macrophages of Schistosoma japonicum infection during different stages by microarray analysis . Acta Tropica .2013 ;(127):251-260

48. 2012 Tasi YT,Cheng PC,Pan TM. The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits . Applied Microbiology and Biotechnology .2012 ;(96):853-862

49. 2011 Cheng PC,Lin CN,Chen YJ,Chang FS,Tsaihong JC,Lee KM. Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses . Parasite Immunology .2011 ;(33):276-286

50. 2010 Tasi YT,Cheng PC,Liao JW,Pan TM. Effect of the administration of Lactobacillus paracasei subsp. paracasei NTU 101 on Peyer's patch-mediated mucosal immunity . International Immunopharmacology .2010 ;(10):791-798

51. 2010 Tsai YT,Cheng PC,Pan TM. Immunomodulating activity of lactobacillus paracasei subsp. paracasei NTU 101 in enterohemorrhagic escherichia coli O157H7-infected mice . Journal of Agricultural and Food Chemistry .2010 ;(58):11265-11272

52. 2008 Chen JY,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC, Lee KM. Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni . International Immunopharmacology .2008 ;(8):458-467

53. 2008 Cheng PC,Hsu CY,Chen CC,Lee KM. In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni . Toxicology and Applied Pharmacology .2008 ;(227):291-298

54. 2008 Peng SY,Lee KM,Tsaihong JC,Cheng PC,Fan PC. Evaluation of recombinant fructose-1,6-bisphosphate aldolase ELISA test for the diagnosis of Schistosoma japonicum in water buffaloes . Research in Veterinary Science .2008 ;(85):527-533

55. 2008 Tasi YT,Cheng PC,Fan CK,Pan TM. Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101 . International Journal of Food Microbiology .2008 ;(128):219-225

56. 2007 Cheng PC,Tsaihong JC,Lee KM. Application of recombinant Sjc26GST for serodiagnosis of Schistosoma japonicum infection in water buffalo (Bos buffelus) . Veterinary Parasitology .2007 ;(150):314-320

57. 2007 Cheng PC,Chou WH,Huang JJ,Masanoyi Sho,Lee KM. 日本血吸蟲26KDa麩胺基硫轉移酶應用於人體日本血吸蟲症之免疫診斷 . 中台學報 .2007 ;(19):147-170


1. 2012 Cheng PC. Evaluating the Potential of Taiwan Antrodia Cinnomomea for Lowering the Side Effects Induced by Radiation Therapy for Cancer Treatment . The 2011 International Conference of Food Factors by Journal of Food and Drug Analysis .2012 ;(20):39

2. 2010 Cheng PC,Chiang PF,Wu YL,Luo TY,Lin WJ,Shen LH. Re 188 labeling HYNIC-trastuzumab enhances and prolongs a longer lasting effect of apoptosis induced by trastuzumab in HER2-overexpression breast cancer cell . The Society of Nuclear Medicine by The Journal of Nuclear Medicine .2010 ;(51):1123-1123

3. 2010 Cheng PC,Chiang PF,Hsu KL,Yeh CH,Chang Y,Liu SW, Lee KM, Lin JW, Shen LH, Luo TY. The study on diagnosis of mouse model with chronic liver damage by applying ASGPR high-affinity glyco-ligand . 中華民國核醫學學會2010年國際學術研討會 .2010

研究計畫

計畫名稱
113 探討血吸蟲病與非感染性致病模型誘發肝星狀細胞活化及肝纖維化的免疫機轉差異
補助單位
國家科學及技術委員會

計畫名稱
112 探討硫代乙醯胺及血吸蟲感染不同模式下誘導肝星狀細胞活化及後續肝纖維化病變的免疫機制差異研究
補助單位
國家科學及技術委員會

計畫名稱
111 血吸蟲蟲卵抗原對於誘發肝癌細胞的凋亡反應之研究
補助單位
國家科學及技術委員會

計畫名稱
111 開發微脂體包覆TXNDC5-siRNA(LNP TXNDC5-siRNA)藥物治療血吸蟲感染症之肝臟纖維化及其有效作用機制探討
補助單位
國家科學及技術委員會

計畫名稱
110 應用質譜分析技術探討曼森血吸蟲可溶性卵抗原中抗纖維化及抗發炎之關鍵蛋白
補助單位
國家科學及技術委員會

計畫名稱
110 開發血吸蟲蟲卵抗原中標的抗原蛋白作為抑制肺部發炎藥物及成分分析與機制研究
補助單位
科技部

計畫名稱
110 111 年度人員生物劑量試驗申請與染色體雙中節分析勞務案
補助單位
行政院原子能委員會核能研究所

計畫名稱
108 SEA調控肺部細胞發炎透過STAT 1 蛋白路徑之研究
補助單位
科技部

計畫名稱
107 應用核醫影像分析模式研究Blimp-1蛋白影響廣東住血線蟲感染之小鼠腦部免疫病理作用
補助單位
科技部

計畫名稱
106 應用核醫影像分析模式研究廣東住血線蟲感染Blimp1基因轉殖及剔除小鼠後腦部的免疫病理變化
補助單位
科技部

計畫名稱
105 曼氏血吸蟲蟲卵抗原調控JAK/STAT1免疫路徑研究
補助單位
科技部

計畫名稱
105 廣東住血線蟲引起腦部發炎的核醫評估模式之開發與應用研究
補助單位

計畫名稱
104 應用nanoPET影像技術分析感染廣東住血線蟲之宿主腦部發炎反應與免疫病理變化
補助單位
科技部

計畫名稱
103 開發血吸蟲抗原作為人類肺部細胞抑制發炎藥物之研究
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
102 血吸蟲感染後巨噬細胞之基因變化研究
補助單位
科技部

計畫名稱
101 TMU101-AE1-B61
補助單位
學校