黃祺真(Huang, Chi-Chen) 副教授

Email
hcc0609@tmu.edu.tw
現   職
神經醫學博士學位學程 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立成功大學基礎醫學研究所 博士
2003/09~2008/05
國立成功大學藥理學系 碩士
2001/09~2003/07
台北醫學大學藥學系 學士
1997/09~2001/07

本校學術經歷

任職單位與職稱[起迄時間]
神經醫學博士學位學程副教授
2022/08/01~
(舊)神經再生醫學博士學位學程副教授
2019/02/01~2022/07/31
(舊)神經再生醫學博士學位學程助理教授
2012/08/01~2019/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
藥理學科
2014/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
國立成功大學專案助理教授
2012/02/01~2012/07/31
中央研究院博士後研究員
2008/07/01~2012/01/31

專長與研究領域

學門領域
醫學之生化及分子生物
學術專長

論文著作

清冊下載


1. 2024 Potential role of solid lipid curcumin particle (SLCP) as estrogen replacement therapy in mitigating TDP-43-related neuropathy in the mouse model of ALS disease . Experimental Neurology .2024 ;(383):114999

2. 2022 TDP-43 is Essential for Eph Receptor-Class-Specific Spinal Motor Axon Trajectory into the Limb . Neuroscience Research .2022 ;(176):31-39

3. 2022 Therapeutic Effect of Rapamycin on TDP-43-Related Pathogenesis in Ischemic Stroke . Int J Mol Sci .2022 ;(24):676

4. 2022 Yi-Syue Tsou,Jing-Huei Lai,Kai-Yun Chen,Cheng-Fu Chang,Chi-Chen Huang. Therapeutic Effect of Rapamycin on TDP-43-Related Pathogenesis in Ischemic Stroke. . Int. J. Mol. Sci. .2022

5. 2020 Po-Chih Chen,Yi-Chen Hsieh,Chi-Chen Huang,Chaur-Jong Hu. Tamoxifen for amyotrophic lateral sclerosis: A randomized double-blind clinical trial . Medicine .2020 ;(99):e20423-e20424

6. 2020 Po-Chih Chen,Dean Wu,Chaur-Jong Hu,Hsin-Yi Chen,Yi-Chen Hsieh,Chi-Chen Huang. Exosomal TAR DNA-binding protein-43 and neurofilaments in plasma of amyotrophic lateral sclerosis patients: A longitudinal follow-up study . Journal of the Neurological Sciences .2020 ;(418):117070-117076

7. 2020 Chu-Jen Kuo,Kuen-Haur Lee,Chi-Chen Huang,I-Fang Wang,Christine Chin-jung Hsieh,Hsin-Chuan Lin, Yi-Chao Lee. Purα regulates the induction of Znf179 transcription during neuronal differentiation . Biochemical and Biophysical Research Communications .2020

8. 2019 Chu-Jen Kuo,Chi-Chen Huang,Szu-Yi Chou,Yu-Chun Lo,Tzu-Jen Kao,Nai-Kuei Huang, Connie Lin, Hsin-Chuan Lin, Hui-Ching Lin, Yi-chao Lee. Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex . Phytomedicine .2019 ;(54):132-139

9. 2019 Po-Chun Tseng,Chih-Feng Kuo,Miao-Huei Cheng,Shu-Wen Wan,Chiou-Feng Lin,Chih-Peng Chang, Yee-Shin Lin, Jiunn-Jong Wu, Chi-Chen Huang, Chia-Ling Chen. HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation during Group A Streptococcal Infection . Frontiers Immunology .2019 ;(10):2147-2159

10. 2019 Titus I. Ekanem TI,Huang CC,Wu MH,Lin DY,Lai WF,Lee KH. Glycidamide Promote the Growth and Migratory Ability of Prostate Cancer Cells by Change the Protein Expression of Cell Cycle Regulators and Epithelial-to-Mesenchymal Transition (EMT)-Associated Proteins with Prognostic Relevance . International Journal of Molecular Sciences .2019 ;(20):2199

11. 2019 Chen WC,Chou WH,Chu HW,Huang CC,Liu X,Chang WP, Chou YH, Chang WC. The rs1256328 (ALPL) and rs12654812 (RGS14) Polymorphisms Are Associated with Susceptibility to Calcium Nephrolithiasis in a Taiwanese population . Scientific Reports .2019

12. 2019 Lin HC,Ching YH,Huang CC,Pao PC,Lee YH,Chang WC, Kao TJ, Lee YC. Promyelocytic Leukemia Zinc Finger Is Involved in the Formation of Deep Layer Cortical Neurons . . Journal of Biomedical Science .2019 ;(26):30

13. 2018 Chih-Ju Chang,Ming-Yuan Chang,Szu-Yi Chou,Chi-Chen Huang,Jian-Ying Chuang, ,Tsung-I Hsu, Hsing-Fang Chang, Yi-Hsin Wu, Chung-Che Wu, Daniel Morales, Artur Kaniaand Tzu-Jen Kao. Ephexin1 is required for Eph-mediated limb trajectory of spinal motor axons. . Journal of Neuroscience .2018 ;(38):2043-2056

14. 2018 Yi-Chao Lee.,Wan-Chen Huang,Jiann-Her Lin,Tzu-Jen Kao,Hui-Ching Lin,Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang, Chi-Chen Huang. Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43-UBI (+)-related neurodegenerative pathology . J. Biomedi. Sci. .2018 ;(25):76

15. 2017 Kuen-Haur Lee,Chi-Long Chen,Yi-Chao Lee,Tzu-Jen Kao,Kai-Yun Chen,Chi-Yu Fang ,Wen-Chang Chang, Yung-Hsaio Chiang, Chi-Chen Huang. Znf179 induces differentiation and growth arrest of human primary glioblastoma multiform in a p53-dependant cell cycle pathway . Sci. Rep. .2017 ;(7):4787-4797

16. 2017 Han-Fang Wu,Yi-Ju Chen,Su-Zhen Wu,Chi-Wei Lee,I-Tuan Chen,Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, and Hui-Ching Lin. Soluble epoxide hydrolase inhibitor and 14, 15-epoxyeicosatrienoic acid-facilitated long-term potentiation through cAMP and CaMKII in the hippocampus . Neural Plasticity .2017 ;(2017):3467805-3467819

17. 2017 Tsui-Chin Huang,Pin-Tse Lee,Ming-Heng Wu,Chi-Chen Huang,Chiung-Yuan Ko,Yi-Chao Lee; Ding-Yen Lin; Ya-Wen Cheng; Kuen-Haur Lee. Distinct Roles and Differential Expression Levels of Wnt5a Isoforms in Colorectal Cancer Cells . Plos One .2017 ;(12):e0181034

18. 2016 Chun-Yu Kao,Pei-Ming Yang,Ming-Heng Wu,Chi-Chen Huang,Yi-Chao Lee,Kuen-Haur Lee. Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells PeerJ 2016(4):1-21. . PeerJ .2016 ;(4):e1683

19. 2016 Cheng-Fu Chang,Yi-Chao Lee,Kuen-Haur Lee,Hui-Ching Lin,Chia-Ling Chen,Che-Kun James Shen, Chi-Chen Huang. Therapeutic effect of berberine on TDP-43- related pathogenesis in FTLD and ALS . Journal of Biomedical Science .2016 ;(23):72-84

20. 2015 Chia-Hung Liu,Wan-Chun Tang,Peik Sia,Chi-Chen Huang,Pei-Ming Yang,Ming-Heng Wu,I-Lu Lai ,Kuen-Haur Lee. Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance. . Int. J. Med. Sci. .2015 ;(12):63-71

21. 2015 Yen-Hao Su,Wan-Chun Tang,Ya-Wen Cheng,Peik Sia,Chi-Chen Huang,Yi-Chao Lee, Hsin-Yi Jiang, Ming-Heng Wu, I-Lu Lai, Jun-Wei Lee, Kuen-Haur Lee. Targeting of Multiple Oncogenic Signaling Pathways by Hsp90 Inhibitor Alone or in Combination with Berberine for Treatment of Colorectal Cancer . BBA - Molecular Cell Research .2015 ;(1853):2261-2272

22. 2015 Yi-Chao Lee,Jun-Wei Lee,Chi-Chen Huang,Ming-Heng Wu,Kuen-Haur Lee. Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues . Data in Brief .2015 ;(4):235-238

23. 2015 Han-Fang Wu,Hsin-Ju Yen,Chi-Chen Huang,Yi-Chao Lee,Su-Zhen Wu,Hui-Ching Lin. Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex . Journal of Biomedical Science .2015 ;(22):94-106

24. 2015 Yi-Chao Lee,Chi-Chen Huang,Ding-Yen Lin,Wen-Chang Chang,Kuen-Haur Lee. Overexpression of centromere protein K (CENPK) in ovarian cancer is correlated with poor patient survival and associated with predictive and prognostic relevance . PeerJ .2015 ;(3):e1386-e1401

25. 2014 Chi-Chen Huang,Jayarama Krishnan Bo,Pritha Majumder,Kuen-Haur Lee,Jen-Tse Joseph Huang,Jeffrey K. Huang, Che-Kun James Shen. Metabolism and Mis-Metabolism of the Neuropathological Signature Protein TDP-43 . Journal of Cell Science .2014 ;(127):3024-3038

26. 2013 Ding-Yen Lin,Chi-Chen Huang,Ya-Ting Hsieh,Hsin-Chuan Lin,Ping-Chieh Pao,Jen-Hui Tsou, Chien-Ying Lai, Liang-Yi Huang, Ju-Ming Wang, Wen-Chang Chang, Yi-Chao Lee. Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf). . J Biomed Sci. .2013 ;(20):98-107

27. 2011 Jayarama Krishnan Bo,Chi-Chen Huang,Che-Kun James Shen. REGULATION OF AUTOPHAGY BY THE NEUROPATHOLOGICAL PROTEIN TDP-43 . THE JOURNAL OF BIOLOGICAL CHEMISTRY .2011 ;(286):44441-44448

28. 2008 Chi-Chen Huang,Yu-Min Wang,Ushio Kikkawa,Hideyuki Mukai,Meng-Ru Shen,Ikuo Morita, Ben-Kuen Chen and Wen-Chang Chang. Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation . Oncogene .2008 ;(27):2422-2429

29. 2007 Ben-Kuen Chen,Chi-Chen Huang,Wei-Chiao Chang,Ushio Kikkawa,Ken-ichi Nakahama,Ikuo Morita, and Wen-Chang Chang. PP2B-mediated Dephosphorylation of c-Jun C Terminus Regulates Phorbol Ester-induced c-Jun/Sp1 Interaction in A431 Cells . Molecular Biology of the Cell .2007 ;(18):1118-1127

研究計畫

計畫名稱
113 探索脂質薑黃素顆粒 SLCP 作為雌激素 E2替代療法用於改善 TDP-43 相關神經病變疾病進展的潛在機制
補助單位
國家科學及技術委員會

計畫名稱
112 TNKS / PI31訊息傳遞路徑在TDP-43相關神經病變中調控蛋白酶體之機制(3/3)
補助單位
國家科學及技術委員會

計畫名稱
111 TNKS / PI31訊息傳遞路徑在TDP-43相關神經病變中調控蛋白酶體之機制(2/3)
補助單位
國家科學及技術委員會

計畫名稱
110 TNKS / PI31訊息傳遞路徑在TDP-43相關神經病變中調控蛋白?體之機制(1/3)
補助單位
科技部

計畫名稱
106 JM化合物對神經退化性疾病小鼠模型的療效研究計畫
補助單位
有聯生技股份有限公司

計畫名稱
106 JM化合物對神經細胞抗氧化能力以及神經退化性疾病之作用機制研究計畫 (細胞模式)
補助單位
有聯生技股份有限公司

計畫名稱
106 探究腦指蛋白Znf179的E3泛素連接酉每活性以及對TDP-43病理蛋白的影響(3/3)
補助單位
科技部

計畫名稱
105 探究腦指蛋白Znf179的E3泛素連接酉每活性以及對TDP-43病理蛋白的影響(2/3)
補助單位
科技部

計畫名稱
105 探究腦指蛋白Znf179的E3泛素連接酉每活性以及對TDP-43病理蛋白的影響(2/3)
補助單位

計畫名稱
104 探究腦指蛋白Znf179的E3泛素連接酉每活性以及對TDP-43病理蛋白的影響(1/3)
補助單位
科技部

計畫名稱
104 探究腦指蛋白Znf179的E3泛素連接?活性以及對TDP-43病理蛋白的影響(1/3)
補助單位
科技部

計畫名稱
103 片段化TDP-43蛋白在缺血性腦中風之神經發炎物質NF-κB 訊息傳遞路徑中所扮演的角色
補助單位
臺北醫學大學附設醫院

計畫名稱
102 黃蓮素對TDP-43蛋白質相關致病機轉的調控在肌萎縮性側索硬化症(ALS)及腦前額顳葉退化症(FTLD)的影響
補助單位
臺北醫學大學附設醫院

計畫名稱
101 探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制
補助單位
行政院國家科學委員會

計畫名稱
101 TMU101-AE1-B32
補助單位
學校