劉如芳(Liu, Ju-Fang) 副教授

Email
jufangliu@tmu.edu.tw
現   職
口腔衛生學系 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
中國醫藥大學藥物化學研究所 博士
2006/09~2010/08
中國醫藥大學藥物化學研究所 碩士
2005/09~2006/08
嘉南藥理科技大學藥學系 學士
2000/09~2004/06

本校學術經歷

任職單位與職稱[起迄時間]
口腔衛生學系副教授
2023/08/01~
口腔衛生學系助理教授
2020/02/15~2023/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
新光醫院研究員
2011/08/01~2020/02/14

專長與研究領域

學門領域
學術專長
中草藥
中草藥
分子藥理
分子藥理
生化藥理
生化藥理
抗發炎
抗發炎
抗癌藥物
抗癌藥物
致癌機轉
致癌機轉
基礎藥理
基礎藥理
細胞凋亡
細胞凋亡
細胞訊息傳遞
細胞訊息傳遞
細胞藥理
細胞藥理
發炎反應
發炎反應
新藥研發
新藥研發
癌症標靶藥理
癌症標靶藥理
癌症藥理
癌症藥理
骨關節疾病
骨關節疾病
關節炎
關節炎
藥學
藥學
中草藥學
中草藥學
新藥開發
新藥開發
基因調控
基因調控

論文著作

清冊下載


1. 2024 Po-Han Chen, Hsein-Kun Lu,Ting-Yi Renn,Tsung-Ming Chang, Chia-Jung Lee,Ya-Ting Tsao, Po-Kai Chuang, Ju-Fang Liu . Plumbagin Induces Reactive Oxygen Species and Endoplasmic Reticulum Stress-related Cell Apoptosis in Human Oral Squamous Cell Carcinoma. . anticancer research .2024 ;(44):1173-1182

2. 2024 Kuo-Ti Peng, Pei-Chun Chen, Jiun-Liang Chen,Tsung-Yu Huang, Yi-Ho Peng,Ju-Fang Liu, Chiang-Wen Lee, Pey-Jium Chang. A comparative phenotypic and genomic analysis of methicillin-resistant Staphylococcus aureus ST45 isolates from cellulitis and from osteomyelitis in Taiwan . The Journal of Infectious Diseases .2024 ;(1):1-10

3. 2024 Tsung-Ming Chang,Miao-Ching Chi,Yao-Chang Chiang,Chieh-Mo Lin,Mei-Ling Fang, Chiang-Wen Lee, Ju-Fang Liu, Yu Ru Kou. Promotion of ROS-mediated apoptosis, G2/M arrest, and autophagy by naringenin in non-small cell lung cancer. . International Journal of Biological Sciences .2024 ;(20):1093-1109

4. 2024 Peng Bou-Yue , Wu Chia-Yu ,Lee Chia-Jung ,Chang Tsung-Ming , Tsao Ya-Ting,Liu Ju-Fang. Nimbolide Induces Cell Apoptosis via Mediating ER Stress-Regulated Apoptotic Signaling in Human Oral Squamous Cell Carcinoma . Environmental Toxicology .2024

5. 2024 Lin Syuan-Ling , Yang Shang-Yu, Tsai Chun-Hao , Fong Yi-Chin , Chen Wei-Li ,Liu Ju-Fang , Lin Chih-Yang, Tang Chih-hsin. Nerve growth factor promote VCAM-1-dependent monocyte adhesion and M2 polarization in osteosarcoma microenvironment: Implications for larotrectinib therapy . International Journal of Biological Sciences .2024 ;(20):4114-4127

6. 2024 Kuo Chun-Lin ,Yeh Skye Hsin-Hsien , Chang Tsung-Ming, Wei Augusta I-Chin,Chen Wei-Jen , Chu Hui-Fang, Tseng Ai-Lun, Lin Pai-Yin, Lin Zih-Chan, Peng Kuo-Ti, Liu Ju-Fang. Bacillus coagulans BACO-17 ameliorates in vitro and in vivo progression of Rheumatoid arthritis . International Immunopharmacology .2024 ;(141):112863

7. 2024 Chen Yi-Hsin,Chu Chih-Chun,Wei Auguesta I-Chin,Liu-Ju-Fang,Lai Hong-Shiee. CXCL1 promotes cell migration in hepatocellular carcinoma by regulating the miR-30b-5p/ICAM-1 axis . Journal of Cancer .2024 ;(15):5007-5019

8. 2023 Shih-Sen Lin,Tsung-Ming Chang, Augusta I-Chin Wei, Chiang-Wen Lee ,Zih-Chan Lin,Yao-Chang Chiang, Miao-Ching Chi, Ju-Fang Liu . Acetylshikonin induces necroptosis via the RIPK1/RIPK3-dependent pathway in lung cancer . Aging (Albany NY) .2023 ;(15):14900-14914

9. 2023 Chang Tsung-Ming,Chiang Yao-Chang ,Lee chiang-Wen,Lin Chieh-Mo,FangMei-Ling,Chi Miao-Ching , Liu Ju-Fang, Kou Yu Ru. CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway . International Journal of Biological Sciences .2023 ;(19):1455-1470

10. 2023 Chang Sunny Li-Yun, Lee Chiang-Wen ,Yang Chen-Yu ,Lin Zih-Chan ,Peng Kuo-Ti,Liu Shih-Chia, Wang Shih-Wei, Tsai Hsiao-Chi, Fong Yi-Chin, Lai Chao-Yang, Huang Yuan-Li, Tasi Chun-Hao, Ko Chih-Yuan, Liu Ju-Fang*, Tang Chih-Hsin. IOX-1 suppresses metastasis of osteosarcoma by upregulating histone H3 lysine trimethylation . BIOCHEMICAL PHARMACOLOGY .2023 ;(210):115472-115482

11. 2023 Liu Po-I,Jiang Ya-Jing,Chang An-Chen,Huang Chang-Lun,Fong Yi-Chin,Guo Jeng-Hung, Liu Chun-Lin, Wang Shih-Wei, Liu Ju-Fang, Chang Sunny Li-Yu,Tang Chih-Hsin. ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis. . Aging .2023 ;(15)

12. 2023 Vo TTT,Wee Y,Cheng HC,Wu CZ,Chen YL,Tuan VP, Liu JF, Lin WN, Lee IT. Surfactin induces autophagy, apoptosis, and cell cycle arrest in human oral squamous cell carcinoma. . Oral Diseases .2023 ;(29):528-541

13. 2023 Chen WC,Chang AC,Tsai HC,Liu PI,Huang CL,Guo JH, Liu CL, Liu JF, Huynh Hoai Thuong L, Tang CH. Bone sialoprotein promotes lung cancer osteolytic bone metastasis via MMP14-dependent mechanisms . Biochemical Pharmacology .2023 ;(211):115540-115552

14. 2023 Tran NB,Lin CY,Chang TK,Fong YC,Thadevoos LA, Lai CY, Huang YL, Tsai CH, Ko CY, Liu JF, Yang SF, Tang CH.. Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR-520f-3p production and suppressing MMP7 expression. . Journal of Pineal Research .2023

15. 2023 Wu CY,Peng PW,Renn TY,Lee CJ,Chang TM,,Wei AI, Liu JF.. CX3CL1 induces cell migration and invasion through ICAM-1 expression in oral squamous cell carcinoma cells. . Journal of Cellular and Molecular Medicine .2023

16. 2023 Liu JF, ,Chen JH, ,Liao SH, ,Chen KL, ,Wei WC, ,Chen TY, Chieh JJ, Huang KW.. Versatile and accessible magnetic diagnosis platform with different magnetic types of magnetic particles for liquid and solid biopsies . International Journal of Molecular Sciences .2023 ;(24):10363

17. 2023 Chang, KW,Wu, CY,Renn, TY,Chang, TM,Wei, AIC,Kung, YY and Liu, JF. Aqueous Extract of Sparganii Rhizoma and Curcumae Rhizoma Induces Apoptosis and Inhibits Migration in Human Oral Squamous Cell Carcinoma . Journal of Food Biochemistry .2023 ;(2023):1-13

18. 2023 Chun-Han Hou , Po-Chun Chen ,Ju-Fang Liu. CXCL1 enhances COX-II expression in rheumatoid arthritis synovial fibroblasts by CXCR2, PLC, PKC, and NF-κB signal pathway . International Immunopharmacology .2023 ;(124):11009-110921

19. 2023 Huang YC,Chen WC,Yu CL,Chang TK,I-Chin Wei A,, Chang TM, Liu JF, Wang SW.. FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression . Biochem Pharmacol .2023 ;(218):115853

20. 2022 Liu JF,Chen PC,Ling TY,Hou CH. Hyperthermia increases HSP production in human PDMCs by stimulating ROS formation, p38 MAPK and Akt signaling, and increasing HSF1 activity. . Stem Cell Res Ther .2022 ;(13):236

21. 2022 Lee CW,Huang CC,Chi MC,Lee KH,Peng KT,Fang ML, Chiang YC, Liu JF. Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines. . Molecules .2022 ;(27):373

22. 2022 Jiang YJ,Chao CC,Chang AC,Chen PC,Cheng FJ,Liu JF, Liu PI, Huang CL, Guo JH, Huang WC, Tang CH. Cigarette smoke-promoted increases in osteopontin expression attract mesenchymal stem cell recruitment and facilitate lung cancer metastasis. . Journal of Advanced Research .2022 ;(41):77-87

23. 2022 Lin TH,Chang SL,Khanh PM,Trang NTN,Liu SC,Tsai HC, Chang AC, Lin JY, Chen PC, Liu JF, Guo JH, Liu CL, Wu HC, Tang CH.. Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression . Cells .2022 ;(11):3285-8396

24. 2022 Wu CY,Liu JF,Tsai HC,Tzeng HE,Hsieh TH,Wang M, Lin YF, Lu CC, Lien MY, Tang CH.. Interleukin-11/gp130 upregulates MMP-13 expression and cell migration in OSCC by activating PI3K/Akt and AP-1 signaling. . Journal of Cellular Physiology .2022

25. 2022 Liu JF,Wee Y,Luo SD,Chang SF,Jia S,Feng SW, Huang HM, Lin JH, Wang CS.. Proanthocyanidins-loaded complex coacervates-based drug delivery attenuates oral squamous cell carcinoma cells metastatic potential through down-regulating the Akt signaling pathway. . Frontiers in Oncology .2022 ;(12):1001126-1001138

26. 2022 Lee CW, Liu JF,Wei WC,Chiang MH,Chen TY, Liao SH, Chiang YC, Kuo WC, Chen KL, Peng KT, Liu YB, Chieh JJ.. Synthesised Conductive/Magnetic Composite Particles for Magnetic Ablations of Tumours . Micromachines (Basel) .2022 ;(13):1605-1617

27. 2022 Lee CW, Chiang MH,Wei WC, Liao SH, Liao SH,Huang KC, Chen KL, Kuo WC, Sung YC, Chen TY, Liu JF, Chiang YC, Shih HN, Peng KT, Chieh JJ.. Highly efficient magnetic ablation and the contrast of various imaging using biocompatible liquid-metal gallium. . BioMedical Engineering OnLine .2022 ;(21):38-49

28. 2022 Liu JF,Chang TM,Chen PH,Lin JS,Tsai YJ,Wu HM, Lee CJ.. Naringenin induces endoplasmic reticulum stress-mediated cell apoptosis and autophagy in human oral squamous cell carcinoma cells. . Journal of Food Biochemistry .2022

29. 2022 Wang GS,Chen JY,Chen WC,Wei IC, Lin SW,Liao KW, Yang TS, Liu JF.. Surfactin induces ER stress-mediated apoptosis via IRE1-ASK1-JNK signaling in human osteosarcoma. . environmental toxicology .2022 ;(37):574-584

30. 2021 Law YY,Lee WF, Hsu CJ,Lin YY,Tsai CH, Huang CC, Wu MH, Tang CH, Liu JF. miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts . Aging (Albany NY) .2021

31. 2021 Han ,Lee,Hsu ,Huang,Lin,Tsai, Huang, Fong, Wu, Liu, Tang. DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts . Journal of Cellular Physiology .2021

32. 2021 Vo, Wee,Cheng,Wu,Chen, Tuan, Liu, Lin, Lee. Surfactin induces autophagy, apoptosis, and cell cycle arrest in human oral squamous cell carcinom . Oral diseases .2021

33. 2021 Tzeng,Lin,Thadevoos ,Ko ,Liu,Huang, Lin, Fong, Tang. The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis . Cancers (Basel) .2021

34. 2021 chao,Lee,Wang,Chun,Yamamoto, Chang, Weng, Liu. CXC chemokine ligand-13 promotes metastasis via CXCR5-dependent signaling pathway in non-small cell lung cancer . Journal of Cellular and Molecular Medicine .2021

35. 2021 Hung,Lin,Yu,Chen,Lien,Huang, Fong, Liu, Wang, Chen, Tang. Visfatin Promotes the Metastatic Potential of Chondrosarcoma Cells by Stimulating AP-1-Dependent MMP-2 Production in the MAPK Pathway . International Journal of Molecular Sciences .2021 ;(22):8642-8651

36. 2021 Lee CW,Chiang YC,Yu PA,Peng KT,Chi MC,Lee MH, Fang ML, Lee KH, Hsu LF, Liu JF. A Role of CXCL1 Drives Osteosarcoma Lung Metastasis via VCAM-1 Production . Frontiers in Oncology .2021 ;(11):735277

37. 2021 Hou CH,Tang CH,Chen PC,Liu JF. Thrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-κB Pathway . Journal of Inflammation Research .2021 ;(14):5955-5967

38. 2021 Wang GS, Chen JY,Chen WC,Wei IC,Lin SW,Liao KW, Yang TS, Liu JF. Surfactin induces ER stress-mediated apoptosis via IRE1-ASK1-JNK signaling in human osteosarcoma . Environmental Toxicology .2021

39. 2021 Tzeng HE,Lin SL,Thadevoos LA,Lien MY,Yang WH,Ko CY, Lin CY, Huang YW, Liu JF, Fong YC, Chen HT, Tang CH.. Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis . Cell Death & Disease .2021 ;(12):1101

40. 2021 Chao CC,Lee WF,Yang WH,Lin CY,Han CK,Huang YL, Fong YC, Wu MH, Lee IT, Tsai YH, Tang CH, Liu JF.. IGFBP-3 stimulates human osteosarcoma cell migration by upregulating VCAM-1 expression . Life Science .2021 ;(265):118758

41. 2021 Liu JF,Chi MC,Lin CY,Lee CW,Chang TM,Han CK, Huang YL, Fong YC, Chen HT, Tang CH.. PM2.5 facilitates IL-6 production in human osteoarthritis synovial fibroblasts via ASK1 activation. . Journal of Cellular Physiology .2021 ;(236):2205-2213

42. 2020 CC,CW,TM,PO,JF. CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in Osteosarcoma . Cancers .2020 ;(12):459

43. 2020 Ming-Horng Tsa,Miao-Ching Chi, Jen-Fu Hsu,I-Ta Lee, Ko-Ming Lin,Mei-Ling Fang, Ming-Hsueh Lee, Chiang-Wen Lee, Ju-Fang Liu. Urban particulate matter enhances ROS/IL-6/COX-II production by inhibiting MicroRNA-137 in synovial fibroblast of rheumatoid arthritis . Cells .2020

44. 2020 Hou SM,Chen PC,Lin CM,Fang ML,Chi MC, Liu JF. CXCL1 contributes to IL-6 expression in osteoarthritis and rheumatoid arthritis synovial fibroblasts by CXCR2, c-Raf, MAPK, and AP-1 pathway . Arthritis Research & Therapy .2020 ;(22):251

45. 2020 Liu JF,Chen PC,Chang TM, Hou CH. Thrombospondin-2 stimulates MMP-9 production and promotes osteosarcoma metastasis via the PLC, PKC, c-Src and NF-κB activation. . Journal of Cellular and Molecular Medicine .2020

46. 2020 Vo TTT,Lee CW,Wu CZ, Liu JF,Lin WN,Chen YL, Hsu LF, Tsai MH, Lee IT.. Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential. . J Cancer .2020 ;(11):6038-6049

47. 2020 Liu JF ,Lee CW,Lin CY,Chao CC,Chang TM,Han CK, Huang YL, Fong YC, Tang CH.. CXCL13/CXCR5 Interaction Facilitates VCAM-1-Dependent Migration in Human Osteosarcoma. . International Journal of Molecular Science .2020 ;(21):6095

48. 2020 Liu JF,Chen PC,Chang TM,Hou CH. Monocyte Chemoattractant Protein-1 promotes cancer cell migration via c-Raf/MAPK/AP-1 pathway and MMP-9 production in osteosarcoma . Journal of Experimental & Clinical Cancer Research .2020 ;(39):254

49. 2020 Tu CT,Liu GL,Liu JF. 人工電子耳再植入術之評估探討:個案報告 . 台灣聽力語言學會雜誌 .2020 ;(42):81-90

50. 2020 Vo TTT,Liu JF,Wu CZ,Lin WN,Chen YL,Lee IT. Surfactin from Bacillus subtilis induces apoptosis in human oral squamous cell carcinoma through ROS-regulated mitochondrial pathway . J Cancer .2020 ;(11):7253-7263

51. 2019 KT,JF,YC,PC,MH,HN, PJ, CW. Particulate matter exposure aggravates osteoarthritis severity. . Clinical Science .2019 ;(133):2171-2187

52. 2019 PC,JF,YC,YL,CC,CH. CCN3 Facilitates Runx2 and Osterix Expression by Inhibiting miR-608 through PI3K/Akt Signaling in Osteoblasts. . International Journal of Molecular Sciences .2019 ;(20):E3300

53. 2019 CW,MC,TM,JF. Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species. . Journal of Cellular Physiology .2019 ;(234):13157-13168

54. 2018 JF,CW,MH,CH,PC,LW, CY, CH, YF, SH, CC. Thrombospondin 2 promotes tumor metastasis by inducing matrix metalloproteinase-13 production in lung cancer cells. . Biochemical Pharmacology .2018 ;(155):537-546

55. 2018 CW,LF,MH,IT,JF,YC, MH. Extracts of Artocarpus communis Induce Mitochondria-Associated Apoptosis via Pro-oxidative Activity in Human Glioblastoma Cells. . Frontiers in Pharmacology .2018 ;(9):411

56. 2018 AC,PC,YC,CM,JF,TH, SM, CH. Osteoblast-secreted WISP-1 promotes adherence of prostate cancer cells to bone via the VCAM-1/integrin α4β1 system. . Cancer Letters .2018 ;(426):47-56

57. 2018 HY,JF,SF,YL,SS. Cytotoxic protobassic acid saponins from the kernels of Palaquium formosanum. . Journal of Food and Drug Analysis .2018 ;(26):557-564

58. 2017 SM,CH,JF. CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts. . Arthritis Research & Therapy .2017 ;(19):282

59. 2017 CC,SM,CC,CH,PC,JF. Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway. . Molecular Medicine Reports .2017 ;(16):5480-5488

60. 2016 JF,CY,HT,CS,CH. BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway. . International Journal of Molecular Sciences .2016 ;(17):E1491

61. 2015 JF,CH,FL,YT,SM. Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma. . International Journal of Molecular Sciences .2015 ;(16):23405-23424

62. 2014 CH,FL,SM,JF. Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-1 signaling pathway. . Molecular Cancer .2014 ;(13):236

63. 2014 CH,FL,SM,JF. Hyperthermia induces apoptosis through endoplasmic reticulum and reactive oxygen species in human osteosarcoma cells. . International Journal of Molecular Sciences .2014 ;(15):17380-17395

64. 2014 YT,CH,SM,JF. The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast. . Mediators Inflamm .2014

65. 2014 CH,FL,KB,SM,JF. Transforming growth factor alpha promotes osteosarcoma metastasis by ICAM-1 and PI3K/Akt signaling pathway. . Biochemical Pharmacology .2014 ;(89):453-463

66. 2013 Hou CH,Tang CH,Hsu CJ,Hou SM,Liu JF. CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts. . Arthritis Research & Therapy .2013 ;(15):R19

67. 2013 liu JF,Hou SM,Tsai CH,Huang CY,Hsu CJ,Tang CH. CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion. . Biochimica et Biophysica Acta-Molecular cell research .2013 ;(1833):966-975

68. 2012 Liu JF,Huang YL,Yang WH,Chang CS,Tang CH. 1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human Chondrosarcoma through Intrinsic and Extrinsic Pathways . International Journal of Molecular Sciences .2012 ;(13):16472-16488

69. 2012 The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways. . Phytomedicine .2012 ;(19):1093-1100

研究計畫

計畫名稱
113 探討 IL11 在肺癌骨轉移中的作用及其調控機制(1/3)
補助單位
國家科學及技術委員會

計畫名稱
113 「探討 IL11 在肺癌骨轉移中的作用及其調控機制」-張琮銘君
補助單位
國家科學及技術委員會

計畫名稱
112 探討人類乳突病毒(HPV)參予口腔細胞腫瘤化之機轉並確認分子標的及治療的新策略
補助單位
國家科學及技術委員會

計畫名稱
112 探討AMPK作用劑調控miRNA對於減緩類風溼性關節炎之相關分子機轉
補助單位
新光醫療財團法人新光吳火獅紀念醫院

計畫名稱
111 探討乙醯紫草素誘導口腔癌細胞壞死性凋亡之分子機制
補助單位
國家科學及技術委員會

計畫名稱
111 探索內質網壓力蛋白IRE1為肺癌新穎標靶並合成出IRE-1為標靶之新一代治療肺癌藥物開發計畫
補助單位
國家科學及技術委員會

計畫名稱
109 益生菌於風濕性關節炎中所扮演的角色研究計畫
補助單位
生展生物科技股份有限公司

計畫名稱
108 新聘教師研究補助
補助單位
臺北醫學大學

計畫名稱
108 探討退化性關節炎臨床用藥所調控微型核醣核酸之藥物開發(3/3)
補助單位
科技部