蔡伊琳(Tsai, I-Lin) 副教授

Email
isabel10@tmu.edu.tw
現   職
生物化學暨細胞分子生物學科 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立台灣大學藥學研究所 博士
2006/09~2011/06
國立台灣大學藥學系 學士
2002/09~2006/06

本校學術經歷

任職單位與職稱[起迄時間]
生物化學暨細胞分子生物學科副教授
2020/08/01~
生物化學暨細胞分子生物學科助理教授
2015/12/02~2020/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際轉譯科學博士學位學程副教授
2021/07/01 ~
藥物科學學科助理教授
2019/11/01 ~
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程助理教授
2017/08/01 ~
(舊)細胞治療與再生醫學國際博士學位學程籌備處助理教授
2017/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院基因體研究中心博士後研究學者
2013/11/01~2015/12/01
國立台灣大學基因體醫學研究中心博士後研究員
2011/09/01~2013/10/31

專長與研究領域

學門領域
分析化學
藥學
學術專長
毛細管電泳
Capillary Electrophoresis
質譜儀
Mass spectrometry
層析
Chromatography

論文著作

清冊下載


1. 2024 Cheng YH,Lee CH,Wang SY,Chou CY,Yang YJ,Kao CC, Wu HY, Dong Y, Hung WY, Su CY, Tseng ST, Tsai IL.. Multiplexed Antibody Glycosylation Profiling Using Dual Enzyme Digestion and Liquid Chromatography-Triple Quadrupole Mass Spectrometry Method . Molecular and Cellular Proteomics .2024

2. 2024 Chou CY,Cheng CY,Lee CH,Kuro-O M,Chen TH,Wang SY, Chuang YK, Yang YJ, Lin YH, Tsai IL*.. Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination . Journal of Microbiology, Immunology and Infection .2024

3. 2023 Huang Han Lun,Tsai I. Lin,Lin Chi,Hang Yu Hao,Ho Yi Cheng,Tsai Min Lang,Mi Fwu Long,Huang Han Lun,Tsai I. Lin,Lin Chi,Hang Yu Hao,Ho Yi Cheng,Tsai Min Lang,Mi Fwu Long. Intelligent films of marine polysaccharides and purple cauliflower extract for food packaging and spoilage monitoring . Carbohydrate Polymers .2023 ;(299)

4. 2022 Ong P,Tung IC,Chiu CF,Tsai IL,Shih HC,Chen SM, Chuang YK*. Determination of aflatoxin B-1 level in rice (Oryza sativa L.) through near-infrared spectroscopy and an improved simulated annealing variable selection method . FOOD CONTROL .2022 ;(136):1-12

5. 2022 Huang GY,Chang WJ,Lu TW,Tsai IL,Wu SJ,Ho MH, Mi FL*. Electrospun CuS nanoparticles/chitosan nanofiber composites for visible and near-infrared light-driven catalytic degradation of antibiotic pollutants . Chemical Engineering Journal .2022 ;(431):1-16

6. 2022 Dai JZ,Wang YJ,Chen CH,Tsai IL,Chao YC,Lin CW*. YAP Dictates Mitochondrial Redox Homeostasis to Facilitate Obesity-Associated Breast Cancer Progression . ADVANCED SCIENCE .2022 ;(9):1-15

7. 2022 Ageng B,Chuang YK,Wang SY,Kao CC*,Tsai IL*. Exosomal proteomics in kidney disease: From technical approaches to clinical applications . Journal of Food and Drug Analysis .2022 ;(30):202-222

8. 2022 Chen HF,Kao CC,Ka SM,Wang SY,Chen MX,Chen GY, Weng TI, Lai RY, Yeh SC, Lin YC, Chen HH, Chang WC, Wu MS, Tsai IL*. Development of an enrichment-free one-pot sample preparation and ultra-high performance liquid chromatography-tandem mass spectrometry method to identify Immunoglobulin A1 hinge region O-glycoforms for Immunoglobulin A nephropathy . Journal of Chromatography A .2022

9. 2022 Chiu HH,Tsai YJ,Lo C,Lin CH,Tsai IL,Kuo CH. Development of an efficient mAb quantification assay by LC-MS/MS using rapid on-bead digestion . Analytica Chimica Acta .2022 ;(1193)

10. 2021 Wang CH,Putri DU,Lee JC,Liao CC,Tsao ST,Hsiao AL, Wu JH, Chen XW, Lee CH, Tsai IL. Biosafety and Proteome Profiles of Different Heat Inactivation Methods for Mycobacterium tuberculosis . Microbiology spectrum .2021 ;(9):1-12

11. 2021 Yang SR,Hung SC,Chu LJ,Hua KF,Wei CW,Tsai IL, Kao CC, Sung CC, Chu P, Wu CY, Chen A, Wu ATH, Liu FC, Huang HS, Ka SM. NSC828779 Alleviates Renal Tubulointerstitial Lesions Involving Interleukin-36 Signaling in Mice . Cells .2021 ;(10)

12. 2021 Chu HY,Huang HC,Huang CY,Chu CC,Su CT,Tsai IL, Hu HLS, Guo SL. A predictive model for identifying low medication adherence among older adults with hypertension: A classification and regression tree model . Geriatric nursing .2021 ;(42):1309-1315

13. 2021 Chen KT,Kang YN,Lin YC,Tsai IL,Chang WC,Fang TC, Wu MS, Kao CC. Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis . Clinical journal of the American Society of Nephrology : CJASN .2021 ;(16):916-925

14. 2021 Tsai IJ,Su E CY,Tsai IL,Lin CY. Clinical Assay for the Early Detection of Colorectal Cancer Using Mass Spectrometric Wheat Germ Agglutinin Multiple Reaction Monitoring . Cancers .2021 ;(13):1-16

15. 2021 Wu LT,Tsai IL,Ho YC,Hang YH,Lin C,Tsai ML, Mi FL. Active and intelligent gellan gum-based packaging films for controlling anthocyanins release and monitoring food freshness . Carbohydrate Polymers .2021 ;(254):1-10

16. 2021 Brahmadhi A,Chen MX,Wang SY,Cho YY,Yu MC,Lee CH, Tsai IL. Determination of fluoroquinolones in dried plasma spots by using microwave-assisted extraction coupled to ultra-high performance liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring . Journal of Pharmaceutical and Biomedical Analysis .2021 ;(195):1-10

17. 2021 Pauline O,Chang HT,Tsai IL,Lin CH,Chen S,Chuang YK. Intelligent assessment of the histamine level in mackerel (Scomber australasicus) using near-infrared spectroscopy coupled with a hybrid variable selection strategy . LWT - Food Science and Technology .2021 ;(145)

18. 2021 Kao CC,Wang SY,Chuang YK,Lee WY,Chang WC,Wu MS, Kuo TC, Tsai IL*. Clinical Mass Spectrometry Discovered Human IgG Sialylation as a Potential Biosignature for Kidney Function . Journal of Personalized Medicine .2021 ;(11):1-11

19. 2021 Chen MX,Su HH,Shiao CY,Chang YT,Chang MC,Kao CC, Wang SY, Shih HC, Tsai IL*. Affinity Purification Coupled to Stable Isotope Dilution LC-MS/MS Analysis to Discover IgG4 Glycosylation Profiles for Autoimmune Pancreatitis . International Journal of Molecular Sciences .2021 ;(22):1-13

20. 2020 Lee KY,Shueng PW,Chou CM,Lin BX,Lin MH,Kuo DY, Tsai IL, Wu SM, Lin CW. Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR-AKT-mTOR signaling . Cancer Science .2020 ;(111):1652-1662

21. 2020 Shiao Jing Ya,Chang Yu Ting,Chang Ming Chu,Chen Michael X.,Liu Li Wei,Wang Xiang Yu, Tsai Yun Jung, Kuo Tai Chih, Tsai I. Lin*. Development of efficient on-bead protein elution process coupled to ultra-high performance liquid chromatography–tandem mass spectrometry to determine immunoglobulin G subclass and glycosylation for discovery of bio-signatures in pancreatic disease . Journal of Chromatography A .2020 ;(1621):1-13

22. 2020 Jhang Ren Shiang,Lin Shin Yi,Peng Yu Fong,Chao Hsi Chun,Tsai I. Lin,Lin Ya Ting,Liao Hsiao Wei,Tang Sung Chun,Kuo Ching Hua. Using the PCI-IS Method to Simultaneously Estimate Blood Volume and Quantify Nonvitamin K Antagonist Oral Anticoagulant Concentrations in Dried Blood Spots . Analytical Chemistry .2020 ;(92):2511-2518

23. 2019 Chang YT,Chang MC,Tsai YJ,Ferng C,Shih HC,Kuo YP, Chen CH, Tsai IL. Method development of immunoglobulin G purification from micro-volumes of human serum for untargeted and targeted proteomics-based antibody repertoire studies . Journal of Food and Drug Analysis .2019 ;(27):475-482

24. 2019 Shih HC,Chang MC,Chen CH,Tsai IL,Wang SY,Kuo YP, Chen CH, Chang YT. High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation. . Clin Proteomics. .2019 ;(16):1-10

25. 2019 Chen HF,Shiao CY,Wu MY,Lin YC,Chen HH,Chang WC, Wu MS, Kao CC*, Tsai IL*. Quantitative determination of human IgA subclasses and their Fc-glycosylation patterns in plasma by using peptide analogue internal standard and ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry . Rapid communications in mass spectrometry .2019 ;(34):1-15

26. 2019 Chen GJ,Lin SW,Tsai IL,Kuo CH,Wang JT,Hsieh SM. Therapeutic drug monitoring of the teicoplanin trough level after the loading doses in patients receiving venoarterial extracorporeal membrane oxygenation . Journal of the Formosan Medical Association .2019

27. 2018 Chiu HH,Liao HW,Shao YY,Lu YS,Lin CH,Tsai IL, Kuo CH. Development of a general method for quantifying IgG-based therapeutic monoclonal antibodies in human plasma using protein G purification coupled with a two internal standard calibration strategy using LC-MS/MS. . Analytica Chimica Acta .2018 ;(1019):93-102

28. 2018 Chen MX,Wang SY,Kuo CH,Tsai IL*. Metabolome analysis for investigating host-gut microbiota interactions. . Journal of the Formosan Medical Association .2018 ;(118):S10-S22

29. 2017 Tsai IL,Kuo CH,Sun HY,Chuang YC,Chepyala D,Lin SW, Tsai YJ. An on-spot internal standard addition approach for accurately determining colistin A and colistin B in dried blood spots using ultrahigh-performance liquid chromatography-tandem mass spectrometry . Journal of Pharmaceutical and Biomedical Analysis .2017 ;(145):783-793

30. 2017 Chiu HH,Tsai IL,Lu YS,Lin CH,Kuo CH. Development of an LC-MS/MS method with protein G purification strategy for quantifying bevacizumab in human plasma. . Analytical and Bioanalytical Chemistry .2017 ;(409):6583-6593

31. 2017 Chen GY,Chao HC,Liao HW,Tsai IL,Kuo CH. Rapid quantification of glutaminase 2 (GLS2)-related metabolites by HILIC-MS/MS. . Analytical Biochemistry .2017 ;(539):39-44

32. 2017 Chepyala D,Tsai IL,Liao HW,Chen GY,Chao HC,Kuo CH*. Sensitive screening of abused drugs in dried blood samples using ultra-high-performance liquid chromatography-ion booster-quadrupole time-of-flight mass spectrometry (UHPLC-IB-QTOF-MS) . Journal of Chromatography A .2017 ;(1491):57-66

33. 2015 Chen GY,Liao HW,Tsai IL,Tseng YJ,Kuo CH. Using the Matrix-Induced Ion Suppression Method for Concentration Normalization in Cellular Metabolomics Studies . Analytical Chemistry .2015 ;(87):9731-9739

34. 2015 Chen GY,Liao HW,Tseng YJ,Tsai IL,Kuo CH. A matrix-induced ion suppression method to normalize concentration in urinary metabolomics studies using flow injection analysis electrospray ionization mass spectrometry . Analytica Chimica Acta .2015 ;(864):21-29

35. 2015 Chepyala D,Tsai IL,Sun HY,Lin SW,Kuo CH. Development and validation of a high-performance liquid chromatography-fluorescence detection method for the accurate quantification of colistin in human plasma . Journal of Chromatography B .2015 ;(980):48-54

36. 2015 Liao HW,Chen GY,Wu MS,Liao WC,Tsai IL,Kuo CH. Quantification of endogenous metabolites by the postcolumn infused-internal standard method combined with matrix normalization factor in liquid chromatography-electrospray ionization tandem mass spectrometry . Journal of Chromatography A .2015 ;(1375):62-68

37. 2015 Liu HY,Hwang TJ,Tsai IL,Kuo CH. Use of high conductivity sample solution with sweeping-micellar electrokinetic chromatography for trace level quantification of paliperidone in human plasma . Electrophoresis .2015 ;(36):534-542

38. 2014 Liao HW,Tsai IL,Chen GY,Lu YS,Lin CH,Kuo CH. Quantification of target analytes in various biofluids using a postcolumn infused-internal standard method combined with matrix normalization factors in liquid chromatography-electrospray ionization mass spectrometry . Journal of Chromatography A .2014 ;(1358):85-92

39. 2014 Liao HW,Chen GY,Tsai IL,Kuo CH. Using a postcolumn-infused internal standard for correcting the matrix effects of urine specimens in liquid chromatography–electrospray ionization mass spectrometry . Journal of Chromatography A .2014 ;(1327):97-104

40. 2013 Tsai IL,Weng TI,Tseng YJ,Tan KL,Sun HJ,Kuo CH. Screening and confirmation of 62 drugs of abuse and metabolites in urine by ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry . Journal of Analytical Toxicology .2013 ;(37):642-651

41. 2013 Tsai IL,Sun HY,Chen GY,Lin SW,Kuo CH. Simultaneous quantification of antimicrobial agents for multidrug-resistant bacterial infections in human plasma by ultra-high pressure liquid chromatography-tandem mass spectrometry . Talanta .2013 ;(116):593-603

42. 2013 Tsai IL,Kuo TC,Ho TJ,Harn YC,Wang SY,Fu WM, Kuo CH, Tseng YJ. Metabolomic dynamic analysis of hypoxia in MDA-MB-231 and the comparison with inferred metabolites from transcriptomics data . Cancers .2013 ;(5):491-510

43. 2013 Tsai DM,Kang JJ,Lee SS,Wang SY,Tsai IL,Chen GY, Liao HW, Li WC, Kuo CH, Tseng YJ. Metabolomic analysis of complex Chinese remedies: examples of induced nephrotoxicity in the mouse from a series of remedies containing aristolochic acid . Evidence-Based Complementary and Alternative Medicine .2013

44. 2013 Liao HW,Tsai IL,Chen GY,Kuo CT,Wei MF,Hwang TJ, Chen WJ, Shen LJ, Kuo CH. Simultaneous detection of single nucleotide polymorphism and copy number variation of CYP2D6 by multiplex PCR combined with capillary electrophoresis . Analytica Chimica Acta .2013 ;(763):67-75

45. 2011 Tsai IL,Liu HY,Kuo PH,Wang JY,Shen LJ,Kuo CH. Quantitative determination of isoniazid in biological samples by Cation Selective Exhaustive Injection-Sweeping-Micellar Electrokinetic Chromatography . Analytical and Bioanalytical Chemistry .2011 ;(401):2205-2214

46. 2011 Wu WC,Tsai IL,Sun SW,Kuo CH. Using sweeping-micellar electrokinetic chromatography to determine melamine in food . Food Chemistry .2011 ;(128):783-789

47. 2010 Chiang PC,Lin SC,Pan SL,Kuo CH,Tsai IL,Kuo MT, Wen WC, Chen P, Guh JH. Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTor pathways . Biochemical Pharmacology .2010 ;(79):162-171

48. 2010 Kuo CH,Lee CW,Lin SC,Tsai IL,Lee SS,Tseng YJ, Kang JJ, Peng FC, Li WC. Rapid determination of aristolochic acids I and II in herbal products and biological samples by UHPLC-MS/MS . Talanta .2010 ;(80):1672-1680

49. 2009 Tsai IL,Sun SW,Liao HW,Lin SC,Kuo CH. Rapid analysis of melamine in infant formula by sweeping-micellar electrokinetic chromatography . Journal of Chromatography A .2009 ;(1216):8296-8303

50. 2009 Tsai IL,Wu L FL,Gau CS,Kuo CH. Method development for the determination of teicoplanin in patient serum by solid phase extraction and micellar electrokinetic chromatography . Talanta .2009 ;(77):1208-1216


1. 2016 Ng SL,Tsai ST,Chu TK,Chen NG,Kuo YP,Tsai IL, Chen CH. Proteomics and transcriptomics of therapeutic ultrasound treatment on pancreatic cells . 64th Annual Conference of American Society of Mass Spectrometry (64th ASMS conference) .2016

2. 2016 Chang YT,Shih HC,Tsai IL,Chen CH,Chen CH*,Chang MC*. Changes in serum immunoglobulin glycosylation after steroid treatment in autoimmune pancreatitis . 20th meeting of the International Association of Pancreatology .2016

3. 2016 Tsai IL,Chang MC,Ferng C,Shih HC,Chang YT*,Chen CH*. Investigation of IgG heavy chain variable region peptides for differential diagnosis of autoimmune pancreatitis and pancreatic adenocarcinoma . 15th Human Proteome Organization World Congress (2016 HUPO) .2016

4. 2016 Tsai IL,Kuo CH,Sun HY,Chepyala D,Lin SW. High Throughput Quantification of Colistin in Dried Blood Spot by Using Ultra-High Pressure Liquid Chromatography-Tandem Mass Spectrometry . Mass Spectrometry: Applications to the clinical Lab (MSACL 2016 EU) .2016

5. 2016 Chiu HH,Tsai IL,Kuo CH*. Development of bevacizumab quantification method in human plasma using immunoglobulin G purification and in-solution digestion . Mass Spectrometry: Applications to the clinical Lab (MSACL 2016 EU) .2016

6. 2016 Tsai IL. Quantitative determination of antibiotics in bio-fluids by using ultra-high performance liquid chromatography-tandem mass spectrometry. (invited oral presentation) . 台灣公定分析化學家協會第八屆第二次會員大會暨學術研討會 .2016

7. 2015 Tsai IL,Chang YT,Chang MC,Ferng C,Shih HC,Kuo YP, Chen CH. Optimization and validation of human immunoglobulin G purification process for label-free proteomics study: application to IgG peptide biomarkers investigation for autoimmune disease . 6th Asia Oceania Mass Spectrometry Conference .2015

8. 2013 Tsai IL,Sun HY,Lin SW,Kuo CH. Simultaneous quantification of antimicrobial agents for multidrug-resistant bacterial infections in human plasma by ultra-high pressure liquid chromatography-tandem mass spectrometry. . 4th Asia Oceania Mass Spectrometry Conference & 10th Taiwan Society for Mass Spectrometry Annual Conference .2013

9. 2011 Tsai IL,Liu HY,Kuo PH,Wang JY,Shen LJ,Kuo CH. Quantitative determination of isoniazid in biological samples by Cation Selective Exhaustive Injection-Sweeping-Micellar Electrokinetic Chromatography . Joint Congress 2011- GC X GC, MSB 2011, ISCC .2011

10. 2010 Tsai IL,Kuo CH. Comprehensive screening of forensic drugs by high performance liquid chromatography coupled with time of flight mass spectrometry . The 7th Taiwan Society for Mass Spectrometry Annual Conference .2010

11. 2009 Tsai IL,Sun SW,Liao HW,Lin SC,Kuo CH. Rapid analysis of melamine in infant formula by sweeping-micellar electrokinetic chromatography . Micro scale bioseparations (MSB) .2009

12. 2007 Tsai IL,Wu L FL,Gau CS,Kuo CH. Method development for the determination of teicoplanin in patient serum by solid phase extraction and micellar electrokinetic chromatography . 12th Internatioinal Meeting on Recent Developments in Pharmaceutical Analysis .2007

研究計畫

計畫名稱
113 開發以外泌體為基礎之急性呼吸窘迫症候群創新診斷與治療平台-開發急性呼吸窘迫症候群之外泌體診斷與治療標的:多體學探勘與創新晶片偵測平台建立(2/3)
補助單位
國家科學及技術委員會

計畫名稱
112 開發以外泌體為基礎之急性呼吸窘迫症候群創新診斷與治療平台-開發急性呼吸窘迫症候群之外泌體診斷與治療標的:多體學探勘與創新晶片偵測平台建立(1/3)
補助單位
國家科學及技術委員會

計畫名稱
112 貴機構依本會「補助國內研究生出席國際學術會議」申請費用補助案(研究生:醫學科學研究所碩士班楊昀蓉君),業經核定
補助單位
國家科學及技術委員會

計畫名稱
112 貴機構依本會「補助國內研究生出席國際學術會議」申請費用補助案(研究生:臨床基因體學暨蛋白質體學碩士學位學程碩士班張天語君),業經核定,請查照辦理。
補助單位
國家科學及技術委員會

計畫名稱
111 建構系統性血清學主軸分析平台解析新冠肺炎感染與疫苗接種的功能性抗體變化
補助單位
國家科學及技術委員會

計畫名稱
111 貴機構依本會「補助國內研究生出席國際學術會議」申請費用補助案(研究生:生化學科碩士班周佳儀君)
補助單位
國家科學及技術委員會

計畫名稱
110 結核菌感染臨床免疫組庫建立:探勘免疫球蛋白於結核菌感染之保護機制與臨床轉譯應用(3/3)
補助單位
科技部

計畫名稱
109 結核菌感染臨床免疫組庫建立:探勘免疫球蛋白於結核菌感染之保護機制與臨床轉譯應用(2/3)
補助單位
科技部

計畫名稱
108 結核菌感染臨床免疫組庫建立:探勘免疫球蛋白於結核菌感染之保護機制與臨床轉譯應用(1/3)
補助單位
科技部

計畫名稱
107 創新高效率免疫球蛋白G分析技術應用於胰臟疾病自體抗體生物標記開發 (第二、三年持續研究)(2/2)
補助單位
科技部

計畫名稱
106 開發微量檢體磁珠式純化技術搭配液相層析-質譜儀探勘人類免疫球蛋白同型分布及κ/λ的比例
補助單位
科技部

計畫名稱
106 創新高效率免疫球蛋白G分析技術應用於胰臟疾病自體抗體生物標記開發 (第二、三年持續研究)(1/2)
補助單位
科技部

計畫名稱
105 生化學科蔡伊琳助理教授擬於105年9月赴奧地利薩爾斯堡參加Mass Spectrometry - Applications to the Clinical Laboratory: 3rd Annual Congress & Exhibition (MSACL 2016 EU)
補助單位
科技部

計畫名稱
105 開發液相層析-質譜儀方法定量血清中IgG subclass: 應用於IgG4 純化流程建立
補助單位
科技部

計畫名稱
105 創新高效率免疫球蛋白G分析技術應用於胰臟疾病自體抗體生物標記開發
補助單位

計畫名稱
104 新聘教師研究補助
補助單位
臺北醫學大學