| 1. |
2024
Wu YW,HuangFu WC,Lin TE,Peng CH,Tu HJ,Sung TY, Sung TY, Yen SC, Pan SL, Hsu KC.
Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule
. International Journal of Biological Macromolecules
.2024
|
|
| 2. |
2024
Lin TE,Dyan Y,HuangFu WC,Wu YW,Hsu JY,Yen SC, Sung TY, Hsieh JH, Pan SL, Yang CR, Huang WJ, Hsu KC.
An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors
. Protein Science
.2024
|
|
| 3. |
2024
Huang CC,Hsu CM,Chao MW,Hsu KC,Lin TE,Yen SC, Tu HJ, Pan SL.
In silico Identification of a Novel Cdc2-like kinase 2 (CLK2) Inhibitor in Triple Negative Breast Cancer
. Protein Science
.2024
|
|
| 4. |
2024
Hsu KC,Huang YY,Chu JC,Huang YW,Hu JL,Lin TE, Yen SC, Weng JR, Huang WJ..
Synthesis and biological evaluation of ortho-phenyl phenylhydroxamic acids containing phenothiazine with improved selectivity for class IIa histone deacetylases
. Journal of Enzyme Inhibition and Medicinal Chemistry
.2024
|
|
| 5. |
2024
Kuan Y,Chu HF,Hsu PH,Hsu KC,Lin TH,Huang CH, Chen WY..
Discovery of Novel Spike Inhibitors against SARS-CoV-2 Infection
. International Journal of Molecular Sciences
.2024
|
|
| 6. |
2024
Lin HY,Tsai TN,Hsu KC,Hsu YM,Chiang LC,El-Shazly M, Chang KM, Lin YH, Tu SY, Lin TE, Du YC, Liu YC, Lu MC..
From Sea to Science: Coral Aquaculture for Sustainable Anticancer Drug Development
. Marine Drugs
.2024
|
|
| 7. |
2024
Kuan Y,Chu HF,Hsu PH,Hsu KC,Lin TH,Huang CH, Chen WY..
Disulfiram inhibits coronaviral main protease by conjugating to its substrate entry site
. International Journal of Biological Macromolecules
.2024
|
|
| 8. |
2024
Tang DW,Chen IC,Chou PY,Lai MJ,Liu ZY,Tsai KK, Cheng LH, Zhao JX, Cho EC, Chang HH, Lin TE, Hsu KC, Chen MC, Liou JP..
HSP90/LSD1 dual inhibitors against prostate cancer as well as patient-derived colorectal organoids
. European Journal of Medicinal Chemistry
.2024
|
|
| 9. |
2024
Tu HJ,Chao MW,Lee CC,Peng CS,Wu YW,Lin TE, Chang YW, Yen SC, Hsu KC, Pan SL, HuangFu WC..
Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation
. Journal of Enzyme Inhibition and Medicinal Chemistry
.2024
|
|
| 10. |
2024
Peng CH,Hwang TL,Hung SC,Tu HJ,Tseng YT,Lin TE, Lee CC, Tseng YC, Ko CY, Yen SC, Hsu KC, Pan SL, HuangFu WC..
Identification, biological evaluation, and crystallographic analysis of coumestrol as a novel dual-specificity tyrosine-phosphorylation-regulated kinase 1A inhibitor
. International Journal of Biological Macromolecules
.2024
|
|
| 11. |
2024
Shih WH,Huang HL,HuangFu WC,Lin TE,Sung TY,Li MC, Huang GL, Chang YW, Yen SC, Hsieh HP, Hsu KC*, Pan SL*.
Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma
. International Journal of Biological Macromolecules
.2024
|
|
| 12. |
2024
Chen JH,Tu HJ,Lin TE,Peng CH,Wu YW,Yen SC, Sung TY, Hsieh JH, Lee HY, Pan SL, HuangFu WC, Hsu KC.
Discovery of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors using an artificial intelligence model and their effects on tau and tubulin dynamics
. Biomedicine & Pharmacotherapy
.2024
|
|
| 13. |
2024
Wu LH,Cheng YW,Lin FL,Hsu KC,Wang MH,Yen JL, Wang TJ, Lin TE, Liu YC, Huang WJ, Hsiao G.
A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress
. Biomedicine and Pharmacotherapy
.2024
|
|
| 14. |
2024
Young MJ,Wang SA,Chen YC,Liu CY,Hsu KC,Tang SW, Tseng YL, Wang YC, Lin SM, Hung JJ..
USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy
. Cell Death and Differentiation
.2024
|
|
| 15. |
2024
Lin SJ,Le PT,Chang YC,Liu CY,Chen YH,Wu CJ, Huang HJ, Hsu KC, Ko TP, Tien NY, Wang HC, Lo CF, Wang HC..
36. Lin SJ, Le PT, Chang YC, Liu CY, Chen YH, Wu CJ, Huang HJ, Hsu KC, Ko TP, Tien NY, Wang HC, Lo CF, Wang HC
. International Journal of Biological Macromolecules
.2024
|
|
| 16. |
2023
Chang CD,Chao MW,Lee HY,Liu YT,Tu HJ,Lien ST, Lin TE, Sung TY, Yen SC, Huang SH, Hsu KC, Pan SL.
In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer
. Journal of Enzyme Inhibition and Medicinal Chemistry
.2023
|
|
| 17. |
2023
Hsu JY,Hsu KC,Sun C,Chou CH,Lin TE,Sung TY, Tseng HJ, Yen SC, Yang CR, Huang WJ.
Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors
. Biomedicine & Pharmacotherapy
.2023
|
|
| 18. |
2023
Lien ST,Lin TE,Hsieh JH,Sung TY,Che JH,Hsu KC.
Establishment of extensive artificial intelligence models for kinase inhibitor prediction: identification of novel PDGFRB inhibitors
. Computers in Biology and Medicine
.2023
|
|
| 19. |
2023
Chin HK,Lu MC,Hsu KC,El-Shazly M,Tsai TN,Lin TY, Shih SP, Lin TE, Wen ZH, Yang YSH, Liu YC. .
Exploration of anti-leukemic effect of soft coral-derived 13-acetoxysarcocrassolide: Induction of apoptosis via oxidative stress as a potent inhibitor of heat shock protein 90 and topoisomerase II
. Kaohsiung Journal of Medical Sciences
.2023
|
|
| 20. |
2023
Ho TY,Sung TY,Pan SL,Huang WJ,Hsu KC,Hsu JY, Lin TE, Hsu CM, Yang CR..
The study of a novel CDK8 inhibitor E966-0530-45418 that inhibits prostate cancer metastasis in vitro and in vivo
. Biomedicine & Pharmacotherapy
.2023
|
|
| 21. |
2023
Lu KJ,Chang CW,Wang CH,Chen FY,Huang IY,Huang PH, Yang CH, Wu HY, Wu WJ, Hsu KC, Ho MC, Tsai MD, Liao JC.
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria
. Nature Metabolism
.2023
|
|
| 22. |
2023
Tu HJ,Su CJ,Peng CS,Lin TE,HuangFu WC,Hsu KC, Hwang TL, Pan SL.
Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity
. Journal of Food and Drug Analysis
.2023
|
|
| 23. |
2023
Chang YJ,Le UNP,Liu JJ,Li SR,Chao ST,Lai HC, Lin YF, Hsu KC, Lu CH, Lin CW.
Combining virtual screening with cis-/trans-cleavage enzymatic assays effectively reveals broad-spectrum inhibitors that target the main proteases of SARS-CoV-2 and MERS-CoV
. Antiviral Research
.2023
|
|
| 24. |
2023
Chu JC,Tseng HJ,Lee SB,Hsu KC,Hsin LW,Liang RH, Lin TE, Gao NC, Chen LC, Lu WH, Wang AHJ, Huang WJ.
Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities
. Journal of Enzyme Inhibition and Medicinal Chemistry
.2023
|
|
| 25. |
2023
Tseng HJ,Banerjee S,Qian B,Lai MJ,Wu TY,Hsu TI, Lin TE, Hsu KC, Chuang KH, Liou JP, Shih JC.
Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma
. European Journal of Medicinal Chemistry
.2023
|
|
| 26. |
2023
Lee S,Chao MW,Wu YW,Hsu CM,Lin TE,Hsu KC, Pan SL, Lee HY.
Synthesis and evaluation of potent (iso)ellipticine-based inhibitors of MYLK4 accessed via expeditious synthesis from isoquinolin-5-ol
. Rsc Advances
.2023
|
|
| 27. |
2022
Maestre-Reyna M,Yang CH,Nango E,Huang WC,Putu EPGN,Wu WJ, Wang PH, Franz-Badur S, Saft M, Emmerich HJ, Wu HY, Lee CC, Huang KF, Chang YK, Liao JH, Weng JH, Gad W, Chang CW, Pang AH, Sugahara M, Owada S, Hosokawa Y, Joti Y, Yamashita A, Tanaka R, Tanaka T, Luo FJ, Tono K, Hsu KC, Kiontke S, Schapiro I, Spadaccini R, Royant A, Yamamoto J, Iwata S, Essen LO, Bessho Y, Tsai MD..
Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme
. Nature Chemistry
.2022
|
|
| 28. |
2022
Lin LC,Chang HY,Lin TE,Lin JR,Hsia SM,Hsu KC, Huang TC..
Structure-based virtual screening discovers novel kidney-type glutaminase inhibitors
. Biomedicine & Pharmacotherapy
.2022
|
|
| 29. |
2022
Yen SC,Chen LC,Huang HL,HuangFu WC,Chen YY,Lin TE, Lien ST, Tseng HJ, Sung TY, Hsieh JH, Huang WJ, Pan SL, Hsu KC.
Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach
. Bioorganic Chemistry
.2022
|
|
| 30. |
2022
Yen SC,Wu YW,Huang CC,Chao MW,Tu HJ,Chen CC, Lin TE, Sung TY, Tseng HJ, Chu JC, Huang WJ, Yang CR, HuangFu WC, Pan SL, Hsu KC.
O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia Phytomedicine
. Phytomedicine
.2022
|
|
| 31. |
2022
Lin TE,Chao MW,HuangFu WC,Tu HJ,Peng ZX,Su CJ, Sung TY, Hsieh JH, Lee CC, Yang CR, Pan SL, Hsu KC.
Identification and Analysis of a Selective DYRK1A Inhibitor
. Biomedicine & Pharmacotherapy
.2022
;(146):112580
|
|
| 32. |
2022
Lu CH,Chung WM,Tsai CH,Cheng JC,Hsu KC,Tzeng HE.
In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interaction
. Scientific Reports
.2022
|
|
| 33. |
2022
Lin TE,Sung LC,Chao MW,Li Min,Zheng JH,Sung TY, Hsieh JH, Yang CR, Lee HY, Cho EC, Hsu KC.
Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
. Journal of Enzyme Inhibition and Medicinal Chemistry
.2022
|
|
| 34. |
2022
Lin TE,Yang CR,Chou CH,Hsu JY,Chao MW,Sung TY, Hsieh JH, Huang WJ, Hsu KC.
Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment
. Biomedicine & Pharmacotherapy
.2022
;(146):112459
|
|
| 35. |
2021
Wang KC,Lu MC,Hsu KC,El-Shazly M,Shih SP,Lien ST,Kuo FW,Yang SC,Chen CL,Yang YCSH.
The antileukemic effect of xestoquinone, a marine-derived polycyclic quinone-type metabolite, is mediated through ros-induced inhibition of hsp-90
. Molecules
.2021
;(26)
|
|
| 36. |
2021
Fan YC,Hsu KC,Lin TE,Zechner D,Hsu SP,Tsai YC.
Investigation of anti-tumor effects of an MLK1 inhibitor in prostate and pancreatic cancers
. Biology
.2021
;(10)
|
|
| 37. |
2021
Chang CH,Wu S,Hsu KC,Huang WJ,Chen JJ.
Dibenzofuran, 4-chromanone, acetophenone, and dithiecine derivatives: Cytotoxic constituents from eupatorium fortunei
. International Journal of Molecular Sciences
.2021
;(22)
|
|
| 38. |
2021
Chao MW,Lin TE,HuangFu WC,Chang CD,Tu HJ,Chen LC,Yen SC,Sung TY,Huang WJ,Yang CR,Pan SL,Hsu KC.
Identification of a Dual TAOK1 and MAP4K5 Inhibitor Using a Structure-Based Virtual Screening Approach
. Journal of Enzyme Inhibition and Medicinal Chemistry
.2021
|
|
| 39. |
2021
Huang KW,Chen JW,Hua TY,Chu YY,Chiu TY,Liu JY, Tu CI, Hsu KC, Kao YT, Chu JW, Hsiao YY.
Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites
. JACS Au
.2021
;(1):2315-2327
|
|
| 40. |
2021
Ojha R,Chen IC,Hsieh CM,Nepali K,Lai RW,Hsu KC, Lin TE, Pan SL, Chen MC, Liou JP.
Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent
. Journal of Medicinal Chemistry
.2021
|
|
| 41. |
2021
Yen SC,Chen LC,Huang HL,Ngo ST,Wu YW,Lin TE,Sung TY,Lien ST,Tseng HJ,Pan SL,Huang WJ,Hsu KC.
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia
. Journal of Natural Products
.2021
|
|
| 42. |
2021
Chang TY,Nepali K,Chen YY,Yang YCSH,Hsu KC,Yen Y,Pan SL,Liou JP,Lee SB.
A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling
. Biomedicine and Pharmacotherapy
.2021
;(138)
|
|
| 43. |
2021
Hsu JY,Rao Sathyan A,Hsu KC,Chen LC,Yen CC,Tseng HJ, Wu KC, Liu HK, Huang WJ.
Synthesis of yakuchinone b-inspired inhibitors against islet amyloid polypeptide aggregation
. Journal of Natural Products
.2021
;(84):1096-1103
|
|
| 44. |
2021
Nepali K,Hsu TI,Hsieh CM,Lo WL,Lai MJ,Hsu KC, Lin TE, Chuang JY, Liou JP.
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma
. European Journal of Medicinal Chemistry
.2021
;(217)
|
|
| 45. |
2021
Huang KF,Huang JS,Wu ML,Hsieh WL,Hsu KC,Hsu HL, Ko TP, Wang AH.
A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes
. Journal of Molecular Biology
.2021
|
|
| 46. |
2021
Wang SA,Young MJ,Wang YC,Chen SH,Liu CY,Lo YA, Jen HH, Hsu KC, Hung JJ.
USP24 promotes drug resistance during cancer therapy
. Cell Death and Differentiation
.2021
|
|
| 47. |
2021
Chang YJ,Yeh CY,Cheng JC,Huang YQ,Hsu KC,Lin YF, Lu CH.
Potent sialic acid inhibitors that target influenza A virus hemagglutinin
. Scientific Reports
.2021
|
|
| 48. |
2021
Wu YW,Chao MW,Tu HJ,Chen LC,Hsu KC,Liou JP, Yang CR, Yen SC, HuangFu WC, Pan SL.
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo
. Oncogenesis
.2021
|
|
| 49. |
2021
Hsu KC,Chu JC,Tseng HJ,Liu CI,Wang HC,Lin TE, Lee HS, Hsin LW, Wang AH, Lin CH, Huang WJ..
Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors
. European Journal of Medicinal Chemistry
.2021
|
|
| 50. |
2021
Singh A,Chang TY,Kaur N,Hsu KC,Yen Y,Lin TE, Lai MJ, Lee SB, Liou JP.
CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition
. European Journal of Medicinal Chemistry
.2021
|
|
| 51. |
2020
Ojha R,Nepali K,Chen CH,Chuang KH, Wu TY,Lin TE,Hsu KC,Chao MW,Lai MJ,Lin MH,Huang HL,Chang CD,Pan SL,Chen MC,Liou JP.
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo
. European Journal of Medicinal Chemistry
.2020
;(190):112086
|
|
| 52. |
2020
Kang CY,Huang IH,Chou CC,Wu TY,Chang JC,Hsiao YY,Cheng CH,Tsai WJ,Hsu KC,Wang S.
Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity
. Journal of Biological Chemistry
.2020
;(295):3734-3745
|
|
| 53. |
2020
Hsu MH,Hsieh CY,Kapoor M,Chang JH,Chu HL,Cheng TM,Hsu KC,Lin TE,Tsai FY,Horng JC.
Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation
. Bioorganic Chemistry
.2020
;(98):103729
|
|
| 54. |
2020
Tseng HJ,Lin MH,Shiao YJ,Yang YC,Chu JC,Chen CY,Chen YY,Lin TE,Su CJ,Pan SL,Chen LC,Wang CY,Hsu KC,Huang WJ.
Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease
. European Journal of Medicinal Chemistry,
.2020
;(192):112193
|
|
| 55. |
2020
Lin CF,Hsu KC,Huangfu WC,Lin TE,Huang LI,Pan SL.
Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury
. BMC Pharmacology & Toxicology
.2020
;(21):21-21
|
|
| 56. |
2020
Nepali K,Chang TY,Lai MJ,Hsu KC,Yen Y, Lin TE,Lee SB,Liou JP.
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors
. European Journal of Medicinal Chemistry
.2020
;(196)
|
|
| 57. |
2020
Liao YT,Lin SJ,Ko TP,Liu CY,Hsu KC,Wang HC.
Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases
. International Journal of Biological Macromolecules
.2020
;(160):903-914
|
|
| 58. |
2020
Liu YC,Peng BR,Hsu KC,El-Shazly M,Shih SP,Lin TE,Kuo FW,Chou YC,Lin HY,Lu MC.
13-acetoxysarcocrassolide exhibits cytotoxic activity against oral cancer cells through the interruption of the keap1/Nrf2/p62/SQSTM1 pathway: The need to move beyond classical concepts
. Marine Drugs
.2020
;(18)
|
|
| 59. |
2020
Hsu KC,HuangFu WC,Lin TE,Chao MW,Sung TY,Chen YY,Pan SL,Lee JC,Tzou SC,Sun CM,Yang JM.
A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors
. Scientific Reports
.2020
;(10)
|
|
| 60. |
2020
Chen LC,Huang HL,HuangFu WC,Yen SC,Ngo ST,Wu YW,Lin TE,Sung TY,Lien ST,Tseng HJ,Pan SL,Huang WJ,Hsu KC.
Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia
. Journal of Natural Products
.2020
|
|
| 61. |
2020
Wu WC,Liu YM,Liao YH,Hsu KC,Lien ST,Chen IC,Lai MJ,Li YH,Pan SL,Chen MC,Liou JP.
Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells
. European Journal of Medicinal Chemistry
.2020
;(203)
|
|
| 62. |
2020
Chou CH,Hsu KC,Lin TE,Yang CR.
Anti-inflammatory and tau phosphorylation–inhibitory effects of eupatin
. Molecules
.2020
;(25):5652
|
|
| 63. |
2020
Magnolol, A Novel Antagonist of Thrombin and PAR-1, Inhibits Thrombin-Induced Connective Tissue Growth Factor (CTGF) Expression in Vascular Smooth Muscle Cells and Ameliorate Pathogenesis of Restenosis in Rats
. Applied Sciences
.2020
|
|
| 64. |
2019
Lai MJ,Ojha R,Lin MH,Lee HY,Lin TE,Hsu KC, Chang CY, ChenMC, Nepali K, Chang JY, Liou JP.
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase
. European journal of medicinal chemistry
.2019
;(162):612-630
|
|
| 65. |
2019
New paradigm of functional regulation by DNA mimic proteins: Recent updates
. Iubmb Life
.2019
;(71):539-548
|
|
| 66. |
2019
Structural Insights to the Heterotetrameric Interaction between the Vibrio parahaemolyticus PirAvp and PirBvp Toxins and Activation of the Cry-Like Pore-Forming Domain
. Toxins
.2019
;(11):233
|
|
| 67. |
2019
Young MJ,Hsu KC,Lin TE,Chang WC,Hung JJ.
The role of ubiquitin-specific peptidases in cancer progression
. Journal of Biomedical Science
.2019
;(26):42
|
|
| 68. |
2019
Lee CC,Chang WH,Chang YS,Yang JM,Chang CS,Hsu KC,Chen YT,Liu TY,Chen YC,Lin Y,Wu YC,Chang JG.
Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide
. Molecular Oncology
.2019
;(13):1744-1762
|
|
| 69. |
2019
NN,Lin MH,Chao MW,Peng SJ,Hsu KC,Lin TE,Chen MC,Lai MJ,Pan SL,Liou JP.
Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells
. Bioorganic Chemistry
.2019
;(91):103119
|
|
| 70. |
2019
Yang PM,Hong YH,Hsu KC,Liu TP .
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma
. American Journal of Cancer Research
.2019
;(9):2120-2139
|
|
| 71. |
2019
Lin CH,Lee HH,Kuei CH,Lin HY,Lu LS,Lee FP,Chang J,Wang JY,Hsu KC,Lin YF.
Nicotinic Acetylcholine Receptor Subunit Alpha-5 Promotes Radioresistance via Recruiting E2F Activity in Oral Squamous Cell Carcinoma
. Journal of Clinical Medicine
.2019
;(8):1454
|
|
| 72. |
2018
Wu YW,Hsu KC ,Lee HY,Huang TC,Lin TE,Chen YL, Sung TY, Liou JP, Hwang-Verslues WW, Pan SL, HuangFu WC.
A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability
. Frontiers in Pharmacology
.2018
;(9):205
|
|
| 73. |
2018
Yeh KT, Hsu KC, Hsu NY, Cheng YW.
miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation
. Oncology Letters
.2018
;(15):8107
|
|
| 74. |
2018
Lee HY,Fan SJ,Huang FI,Chao HY,Hsu KC,Lin TE, Yeh TK, Lai MJ, Li YH, Huang HL, Yang CR, Liou JP.
5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes
. Journal of Medicinal Chemistry
.2018
;(61):7087-7102
|
|
| 75. |
2018
Chen LC ,Tseng HJ,Liu CY,Huang YY,Yen CC,Weng JR, Lu YL, Hou WC, Lin TE, Pan IH, Huang KK, Huang WJ, Hsu KC.
Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and beta-amyloid Aggregation
. Frontiers in Pharmacology
.2018
;(9):708
|
|
| 76. |
2018
Lin TE,HuangFu WC,Chao MW,Sung TY,Chang CD,Chen YY,Hsieh JH,Tu HJ,Huang HL,Pan SL,Hsu KC.
A novel selective JAK2 inhibitor identified using pharmacological interactions
. Frontiers in Pharmacology
.2018
;(9):1379
|
|
| 77. |
2018
Chao SW,Chen LC,Yu CC,Liu CY,Lin TE,Guh JH, Wang CY, Chen CY, Hsu KC, Huang WJ.
Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities
. European Journal of Medicinal Chemistry
.2018
;(143):792-805
|
|
| 78. |
2017
Huang MF,Lin SJ,Ko TP,Liao YT,Hsu KC,Wang HC.
The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein
. PLoS One 2017
.2017
;(12):e0189461
|
|
| 79. |
2017
Hsu KC,Hung HC,HuangFu WC,Sung TY,Eight Lin T,Fang MY, Chen IJ, Pathak N, Hsu JT, Yang JM.
Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains
. Scientific Reports.
.2017
;(7):12336
|
|
| 80. |
2017
Chen LC,Hsu KC,Chiou LC,Tseng HJ,Huang WJ.
Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative
. Molecules
.2017
;(22)
|
|
| 81. |
2017
Lin SJ,Hsu KC,Wang HC.
Structural Insights into the Cytotoxic Mechanism of Vibrio parahaemolyticus PirAvp and PirBvp Toxins
. Marine Drugs
.2017
;(15):373
|
|
| 82. |
2017
Chen CH,Changou C ,Hsieh TH,Lee YC,Chu CY,Hsu KC, Wang HC, Lin YC, Lo YN, Liu YR, Liou J P, Yen Y.
Dual Inhibition of PIK3C3 and FGFR as a New Therapeutic Approach to Treat Bladder Cancer
. Clinical Cancer Research
.2017
|
|
| 83. |
2017
Chao MW,Huang HL,HuangFu WC,Hsu KC,Liu YM,Wu YW, Lin CF, Chen YL, Lai MJ, Lee HY, Liou JP, Teng CM, Yang CR.
An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells
. Oncotarget
.2017
|
|
| 84. |
2017
Hsu KC,Liu CY,Lin TE,Hsieh JH,Sung TY,Tseng HJ, Yang JM, Huang WJ.
Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach.
. Scientific reports
.2017
;(7):3228
|
|
| 85. |
2016
Lin CH,Wu YR,Yang JM,Chen WL,Chao CY,Chen IC, Lin TH, Wu YC, Hsu KC, Chen CM, Lee GC, Hsieh-Li HM, Lee CM, Lee-Chen GJ.
Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3
. Cns & Neurological Disorders-Drug Targets
.2016
;(15):351-359
|
|
| 86. |
2016
Wang HC,Ho CH,Chou CC,Ko TP,Huang MF,Hsu KC, Wang AHJ.
Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase
. Nucleic Acids Research
.2016
;(44):4440-4449
|
|
| 87. |
2016
Chung YL,Pan CH,Wang CCN,Hsu KC,Sheu MJ,Chen HF, Wu CH.
Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo
. Journal of Natural Products
.2016
;(79):1635-1644
|
|
| 88. |
2016
Das A,Adak AK,Ponnapalli K,Lin CH,Hsu KC,Yang JM, Hsu TA, Lin CC.
Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors
. European Journal of Medicinal Chemistry
.2016
;(123):397-406
|
|
| 89. |
2016
Huang KW,Hsu KC,Chu LY,Yang JM,,Yuan HS,Hsiao YY.
Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate
. Journal of Medicinal Chemistry
.2016
;(59):8019-8029
|
|
| 90. |
2015
Hsu KC,Sung TY,Lin CT,Chiu YY,Hsu JTA,Hung HC, Sun CM, Barve I, Chen WL, Huang WC, Huang CT, Chen CH, Yang JM.
Anchor-based classification and type-C inhibitors for tyrosine kinases
. Scientific Reports
.2015
;(5):10938-10951
|
|
| 91. |
2015
Lee GC,Lin CH,Tao YC,Yang JM,Hsu KC,Huang YJ, Huang SH, Kung PJ, Chen WL, Wang CM, Wu YR, Chen CM, Lin JY, Hsieh-Li HM, Lee-Chen GJ.
The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment
. Neurotoxicology
.2015
;(48):120
|
|
| 92. |
2014
Chiu YY,Tseng JH,Liu KH,Lin CT,Hsu KC,Yang JM.
Homopharma: A new concept for exploring the molecular binding mechanisms and drug repurposing
. Bmc Genomics
.2014
;(15 Sup):S8
|
|
| 93. |
2014
Lee CC,Maestre-Reyna M,Hsu KC,Wang HC,Liu CI,Jeng WY, Lin LL, Wood R, Chou CC, Yang JM, Wang AHJ.
Crowning Proteins: Modulating the Protein Surface Properties using Crown Ethers
. Angewandte Chemie-International Edition
.2014
;(53):13054
|
|
| 94. |
2014
Ma NH,Lai CS,Chung CH,Yang JM,Hsu KC,Hsu KC, Chen CY, Chung TS, Li SM, Ho CT, Pan MH.
5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis.
. Journal of Functional Foods
.2014
;(11):528
|
|
| 95. |
2014
Chu CH,Wang LY,Hsu KC,Chen CC,Cheng HH,Wang SM, Wu CM, Chen TJ, Li LT, Liu RW, Hung CL, Yang JM, Kung HJ, Wang WC.
KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor
. Journal of Medicinal Chemistry
.2014
;(57):5975
|
|
| 96. |
2014
Wang HC,Ho CH,Hsu KC,Yang JM,Wang AHJ.
DNA Mimic Proteins: Functions, Structures, and Bioinformatic Analysis
. Biochemistry
.2014
;(53):2865
|
|
| 97. |
2014
Wang HC,Hsu KC,Yang JM,Wu ML,Ko TP,Lin SR, Wang AHJ.
Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor
. Nucleic Acids Research
.2014
;(42):1354
|
|
| 98. |
2013
Hsu KC,Cheng WC,Chen YF,Wang WC,Yang JM.
Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways.
. Plos Computational Biology
.2013
;(9):e10031
|
|
| 99. |
2013
Lin CH,Chang TC,Das A,Fang MY,Hung HC,Hsu KC, Yang JM, von Itzstein M, Mong KKT, Hsu TA, Lin CC.
Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities
. Organic & Biomolecular Chemistry
.2013
;(11):3943
|
|
| 100. |
2013
Hsu KC,Hung HC,Horng JT,Fang MY,Chang CY,Li LT, Chen IJ, Chen YC, Chou DL, Chang CW, Hsieh HP, Yang JM, Hsu JTA.
Parallel Screening of Wild-Type and Drug-Resistant Targets for Anti-Resistance Neuraminidase Inhibitors
. PLoS One
.2013
;(8):e56704
|
|
| 101. |
2013
Chiu YY,Lin CT,Huang JW,Hsu KC,Tseng JH,You SR, Yang JM.
KIDFamMap: a database of kinase-inhibitor-disease family maps for kinase inhibitor selectivity and binding mechanisms
. Nucleic Acids Research
.2013
;(41):D430
|
|
| 102. |
2012
Cheng WC,Chen YF,Wang HJ,Hsu KC,Lin SC,Chen TJ, Yang JM, Wang WC.
Structures of Helicobacter pylori Shikimate Kinase Reveal a Selective Inhibitor-Induced-Fit Mechanism
. Plos One
.2012
;(7):e33481
|
|
| 103. |
2012
Hsu KC,Cheng WC,Chen YF,Wang HJ,Li LT,Wang WC, Yang JM.
Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries.
. PLoS One
.2012
;(7):e32142
|
|
| 104. |
2012
Hsu KC,Chen YF,Yang JM.
GemAffinity: a scoring function for predicting binding affinity and Virtual Screening
. International Journal of Data Mining and Bioinformatics
.2012
;(6):27
|
|
| 105. |
2012
Chiu YY,Lin CY,Lin CT,Hsu KC,Chang LZ,Yang JM.
Space-related pharma-motifs for fast search of protein binding motifs and polypharmacological targets
. BMC Genomics
.2012
;(13Sup7):S21
|
|
| 106. |
2011
Clinciu DL,Yang JM,Hsu KC,Lo CC,Wallace S,Yu HC.
The Relevance of Protein-Ligand Interaction Profiles in Computer-Aided Novel Compound Design and Applications
. Current Bioinformatics
.2011
;(6):383
|
|
| 107. |
2011
Tsai CC,Liu HF,Hsu KC,Yang JM,Chen CP,Liu KK, Hsu TS, Chao JI.
7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration
. Biochemical Pharmacology
.2011
;(81):856
|
|
| 108. |
2011
Hsu KC,Chen YF,Lin SR,Yang JM.
iGEMDOCK: a graphical environment of enhancing GEMDOCK using pharmacological interactions and post-screening analysis
. Bmc Bioinformatics
.2011
;(12Sup1):S33
|
|
| 109. |
2010
Chen YF,Hsu KC,Lin SR,Wang WC,Huang YC,Yang JM.
SiMMap: a web server for inferring site-moiety map to recognize interaction preferences between protein pockets and compound moieties
. Nucleic Acids Research
.2010
;(38):W424
|
|
| 110. |
2010
Liu KP,Hsu KC,Huang JW,Chang LS,Yang JM.
ATRIPPI: An Atom-Residue Preference Scoring Function for Protein-Protein Interactions
. International Journal on Artificial Intelligence Tools
.2010
;(19):251
|
|