1. |
2024
Cheng WH,Chang PL,Wu YC,Wang SA,Chen CL,Hsu FL, Neoh MM, Lin LY, Yulian FS, Lin CH, Chen BC.
Neutralization of CX3CL1 Attenuates TGF-β-Induced Fibroblast Differentiation Through NF-κB Activation and Mitochondrial Dysfunction in Airway Fibrosis
. Lung
.2024
;(00):00-00
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2. |
2024
Liu CH,Lee HS,Liou JP,Hua HS,Cheng WH,Yuliani FS, Chen BC, Lin CH.
MPT0E028, a novel pan-HDAC inhibitor, prevents pulmonary fibrosis through inhibition of TGF-β-induced CTGF expression in human lung fibroblasts: involvement of MKP-1 activation
. Eur J Pharmacol (In Press)
.2024
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3. |
2023
Cheng WH,Kao SY,Chen CL,Yuliani FS,Lin LY,Lin CH, Chen BC.
Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells
. Respir Res
.2023
;(23)
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4. |
2023
Hua HS,Wen HC,Lee HS,Weng CM,Yuliani FS,Kuo HP, Chen BC, Lin CH.
Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex
. J Biomed Sci.
.2023
;(30):1-16
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5. |
2022
Yuliani FS,Che JY,Cheng WH,Wen HC,Chen BC,Lin CH.
Thrombin induces IL‑8/CXCL8 expression by DCLK1‑dependent RhoA and YAP activation in human lung epithelial cells
. J Biomed Sci
.2022
;(29):1-22
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6. |
2021
Chen JY,Cheng WH,Lee KY,Kuo HP,Chung KF,Chen CL, Chen BC, Lin CH.
Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma
. Biomed Pharmacother
.2021
;(140):1-12
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7. |
2021
Hua HS,Wen HC,Weng CM,Lee HS,Chen BC,Lin CH.
Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation
. J Biomed Sci
.2021
;(28):1-12
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8. |
2021
Cheng WH,Chen CL,Chen JY,Lin CH,Chen BC.
Hypoxia-induced Preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway
. Mol Med
.2021
;(27):1-19
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9. |
2021
Cheng WH,Lee KY,Yu MC,Chen JY,Lin CH,Chen BC.
Pref-I induced lung fibroblast differentiation by hypoxia through integrin a5b1/ERK/AP-1 cascade
. Eur J Pharmacol
.2021
;(909):1-11
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10. |
2020
Lin CH,Shih CH,Jiang CP,Wen HC,Cheng WH,Chen BC.
Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells
. Eur J Pharmacol
.2020
;(868):1-8
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11. |
2020
Ou SC,Bai KJ,Cheng WH,Chen JY,Lin CH,Wen HC, Chen BC.
TGF-β Induced CTGF Expression in Human Lung Epithelial Cells through ERK, ADAM17, RSK1, and C/EBPβ Pathways
. Int J Mol Sci
.2020
;(21):1-17
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12. |
2019
Chen YC,Chen BC,Huang HM,Lin SH,Lin CH.
Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin (In press)
. J Cell Physiol
.2019
;(00):1-12
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13. |
2019
Lee HS,Hua HS,Wang CH,Yu MC,Chen BC,Lin CH.
Mycobacterium tuberculosis induces connective tissue growth factor expression through the TLR2-JNK-AP-1 pathway in human lung fibroblasts.
. FASEB J.
.2019
;(33):12554-12564
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14. |
2018
Lin CH,Shih CH,Lin YC,Yang YL,Chen BC.
MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
. Journal of Biomedical Science
.2018
;(25):1-11
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15. |
2018
Chen HU,Lin CH,Chen BC.
ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts
. Exp Cell Res
.2018
;(370):39-45
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16. |
2017
Chen JY,Lin CH,Chen BC.
Hypoxia-induced ADAM 17 expression is mediated by RSK1-dependent C/EBPβ activation in human lung fibroblasts.
. Mol Immunol
.2017
;(88):155-163
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17. |
2017
Huang ZW,Lien GS,Lin CH,Jiang CP,Chen BC.
p300 and C/EBP-regulated IKK expression are involved in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells
. Pharmacol Res
.2017
;(121):33-41
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18. |
2016
Lien GS,Lin CH,Yang YL,Wu MS,Chen BC.
Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways
. Eur J Pharmacol
.2016
;(776):124-131
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19. |
2016
Chen YC,Chen BC,Yu CC,Lin SH,Lin CH.
miR-19a, -19b, and -26b Mediate CTGF Expression and Pulmonary Fibroblast Differentiation
. J Cell Physiol
.2016
;(231):2236-2248
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20. |
2016
Lin CH,Wang YH,Chen YW,Lin YL,Chen BC,Chen MC.
Transcriptional and posttranscriptional regulation of CXCL8/IL-8 gene expression induced by connective tissue growth factor
. Immunol Res
.2016
;(64):369-384
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21. |
2016
Cheng Y,Lin CH,Chen JY,Li CH,Liu YT,Chen BC.
Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways
. PLoS One
.2016
;(11):e01605-93
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22. |
2015
Lin CH#,Shih CH#,Chen BC.
Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-kB pathways in human lung epithelial cells (#:共同第一作者)
. Eur J Pharmacol
.2015
;(767):135-143
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23. |
2014
Lin CH,Nai PL,Bien MY,Chen BC.
Thrombin-Induced CCAAT/Enhancer-Binding Protein beta Activation and IL-8/CXCL8 Expression via MEKK1, ERK, and p90 Ribosomal S6 Kinase 1 in Lung Epithelial Cells
. Journal of Immunology
.2014
;(192):338-348
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24. |
2014
Weng CM,Yu CC,Kuo ML,Chen BC*,Lin CH*.
Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway
. Biochemical Pharmacology
.2014
;(88):402-411
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25. |
2014
Lin CH,Shih CH,Tseng CC,Yu CC,Tsai YJ,Bien MY, Chen BC.
CXCL12 induces connective tissue growth factor expression in human lung fibroblasts through the Rac1/ERK, JNK, and AP-1 pathways
. PLOS one
.2014
;(9):e10474
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26. |
2014
Lien GS,Wu MS,Bien MY,Chen CH,Lin CH,Chen BC.
Epidermal growth factor stimulates nuclear factor-kB activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells
. PLOS one
.2014
;(9):e10489
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27. |
2013
Bai KJ,Chen BC,Pai HC,Weng CM,Yu CC,Hsu MJ, Yu MC, Ma HP, Wu CH, Hong CY, Kuo ML, Lin CH.
Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/JAK2/STAT3 pathway
. J Leukoc Biol
.2013
;(93):101-112
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28. |
2013
Lin CH,Yu MC,Chiang CC,Bien MY,Chien MH,Chen BC.
Thrombin-induced NF-kB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells
. Cellular Signalling
.2013
;(25):1166-1175
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29. |
2013
Weng CM,Chen BC,Wang CH,Feng PH,Lee MJ,Huang CD, Kuo HP, Lin CH.
The endothelin A receptor mediates fibrocyte differentiation in chronic obstructive asthma. The involvement of connective tissue growth factor
. Am J Respir Crit Care Med (共同第一作者)
.2013
;(188):298-308
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30. |
2013
Lin CH,Yu MC,Tung WH,Chen TT,Yu CC,Weng CM, Tsai YJ, Bai KJ, Hong CY, Chien MH, Chen BC.
Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway
. BBA - Molecular Cell Research
.2013
;(1833):2823-2833
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31. |
2012
Weng HY,Hsu MJ,Chen CC,Chen BC,Hong CY,Teng CM, Pan SL, Chiu WT, Lin CH.
Eur J Pharmacol
. Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade
.2012
;(xx):xx-xx
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32. |
2012
Ko WC,Chen BC,Hsu MJ,Tsai CT,Hong CY,Lin CH.
Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway
. Acta Pharmacol Sin
.2012
;(33):49-56
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33. |
2012
Weng HY,Hsu MJ,Wang CC,Chen BC,Hong CY,Chen MC, Chiu WT, Lin CH.
Zerumbone suppresses IKKalpha, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells
. J Biomed Sci
.2012
;(19):86-xx
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34. |
2011
Lin CH,Cheng HW,Ma HP,Wu CH,Hong CY,Chen BC.
Thrombin induces NF-kB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway
. The Journal of Biological Chemistry
.2011
;(286):10483-10494
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35. |
2011
Lin CC,Shih CH,Yang YL,Bien MY,Lin, CH,Yu MC, Sureshbabu M, Chen BC.
Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages
. European Journal of Pharmacology
.2011
;(672):180-187
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36. |
2010
Tzeng JI,Chen BC,Chang HM,Wang JJ,Sureshbabu M,Chien MH, Hsu MJ, Bien MY, Chiu WT, Hong CY, Lin CH.
Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages
. Pharmacologic Research
.2010
;(61):162-166
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37. |
2010
Hsu MJ,Chang CK,Chen MC,Chen BC,Ma HP,Hong CY, Lin CH.
Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages
. Journal of Leukocyte Biology
.2010
;(87):1069-1082
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38. |
2009
Chen, BC,Kang, JC,Lu, YT,Hsu, MJ,Liao, CC,Chiu WT, Yeh FL, Lin CH.
Rac1 regulates peptidoglycan-induced nuclear factor-kB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway
. Molecular Immunology
.2009
;(46):1179-1188
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39. |
2009
Chang MS,Chen BC,Weng CM,Lee WS,Lin CH.
Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells
. Pharmacological Research
.2009
;(60):247-253
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40. |
2009
Yu CC,Hsu MJ,Kuo ML,Chen RFC,Chen MC,Bai KJ, Yu MJ, Chen BC*, Lin CH*.
Thrombin-Induced Connective Tissue Growth Factor Expression in Human Lung Fibroblasts Requires the ASK1/JNK/AP-1 Pathway
. The Journal of Immunology
.2009
;(182):7916-7927
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41. |
2009
Chen BC,Chang HM,Hsu MJ,Shih CM,Chiu YH,Chiu WT, Lin CH.
Peptidoglycan induces cyclooxygenase-2 expression in macrophages by activating the neutral sphinomylinase-ceramide pathway
. The Journal of Biological Chemistry
.2009
;(284):20562-20573
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42. |
2009
Shih CH,Bien MY,Chiang LL,Su CL,Lin CH,Chen BC.
Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kB pathways in human lung fibroblasts
. European Journal of Pharmacology
.2009
;(618):70-75
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43. |
2009
Kao CT,Chen BC,Hsu MJ,Chen CC,Chen MC,Teng CM, Pan SL, Bien MY, Shih CH, Lin CH.
Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells
. Journal of Biomedical Science
.2009
;(16:43):1-15
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44. |
2009
Ho SC,Lee KY,Chan YF,Kuo LW,Ito K,Adcock IM, Chen BC, Sheu JR, Lin CH, Kuo HP.
Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kB repressing factor
. Journal of Immunology
.2009
;(183):411-420
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45. |
2008
Wang-SY,Tsai, CM,Chen, BC,Lin, CH,Lin, CC.
Symptom clusters and relationships to symptom interference with daily life in Taiwanese lung cancer patients
. J Pain Symptom Manage
.2008
;(35):258-266
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46. |
2008
Kuo, CT,Hsu, MJ,Chen, BC,Chen, CC,Teng, CM,Pan, SL, Lin CH.
Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction
. Toxicol Lett
.2008
;(177):48-58
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47. |
2007
Lin CC,Chiang LL,Lin CH,Shih CH,Liao YT,Hsu MJ, Chen BC*.
Transforing growth factor-b1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kB pathways in human lung epithelial cells
. European Journal of Pharmacology
.2007
;(560):101-109
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48. |
2007
Hsu, MJ,Hsu, CY,Chen, BC,Chen, MC,Ou, George,Lin, CH.
Apoptosis signal-regulating kinase 1 in amyloid beta peptide-induced cerebral endothelial cell apoptosis
. J Neurosci
.2007
;(27):5719-5729
|
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49. |
2006
Ho FM,Lin WW,Chen BC,Chao CM,Yang CR,Lin LY, Lai CC, Liu SH, Liau CS.
High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway.
. Cellular Signaling
.2006
;(18):391-399
|
|
50. |
2006
Chen BC,Liao CC,Hsu MJ,Liao YT,Lin CC,Sheu JR, Lin CH.
Peptidoglycan-Induced Interleukin-6 Production in RAW 264.7 Macrophages Is Mediated by Cyclooxygenase-2, EP2/EP4 Receptors, Protein Kinase A, IκB Kinase, and Nuclear Factor-κB (accepted)
. The Journal of Immunology
.2006
;(177):681-693
|
|
51. |
2006
Lin CH,Cheng HW,Hsu MJ,Chen MC,Lin CC,Chen BC*.
c-Src Mediates Thrombin-Induced NF-kB Activation and IL-8/CXCL8 Expression in Lung Epithelial Cells
. Journal of Immunology
.2006
;(177):3472-3438
|
|
52. |
2005
Chang MS,Chen BC,Yu MT,Sheu JR,Chen TF,Lin CH.
Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK and NF-kB, but not p38 MAPK, pathway
. Cellular Signalling
.2005
;(17):299-310
|
|
53. |
2005
Kao SJ,Lei HC,Kuo CT,Chang MS,Chen BC,Chang YC, Chiu Wt, Lin CH.
Lipoteichoic acid induces nuclear factor-kB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages
. Immunology
.2005
;(115):366-374
|
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54. |
2004
Chen BC,Chang YS,Kang JC,Hsu MJ,Sheu JR,Chen TL, Teng CM, Lin CH.
Peptidoglycan Induces Nuclear Factor-kB Activation and Cyclooxygenase-2 Expression via Ras, Raf-1, and ERK in RAW 264.7 Macrophages
. The Journal of Biological Chemistry
.2004
;(279):20889-20897
|
|
55. |
2004
Chang MS,Lee WS,Chen BC,Sheu JR,Lin CH.
YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kB in human pulmonary epithelial cells
. Molecular Pharmacology
.2004
;(66):561-571
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56. |
2004
Chen BC,Yu CC,Lei HC,Chang MS,Hsu MJ,Huang CL, Chen MC, Sheu, JH, Chen TF, ..... Lin CH.
Bradykinin B2 receptor mediates NF-kB activation and cyclooxygenase-2 expression via the Ras/Raf/ERK pathway in human airway epithelial cells
. The Journal of Immunology
.2004
;(173):5219-5228
|
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57. |
2002
Chen BC and Lin WW.
Inhibition of interleukin-1b-induced NF-kB activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation, associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88.
. Journal of Biological Chemistry
.2002
;(277):24169-24179
|
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58. |
2001
Chen BC and Lin WW.
PKC- and ERK-dependent activation of IkB kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation.
. British Journal of Pharmacology
.2001
;(134):1055-1065
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59. |
2001
Chen BC, Hsieh SL and Lin WW.
Involvement of protein kinases in the potentiation of lipopolysaccharide-induced inflammatory mediator formation by thapsigargin in peritoneal macrophages.
. Journal of Leukocyte Biology
.2001
;(69):280-288
|
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60. |
2000
Chen BC and Lin WW.
Pyrimidinoceptor potentiation of macrophage PGE2 release involved in the induction of nitric oxide synthase.
. British Journal of Pharmacology
.2000
;(130):777-786
|
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61. |
1999
Chen BC and Lin WW.
Potentiation of lipopolysaccharide-induced IL-6 release by uridine triphosphate in macrophages: cross interaction with cyclooxygenase-2-dependent prostaglandinE2 production.
. Journal of Biomedical Science
.1999
;(6):425-432
|
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62. |
1999
Chen BC and Lin WW.
PKCbI mediates the inhibition of P2Y receptor-induced inositol phosphate formation in endothelial cells.
. British Journal of Pharmacology 127: 1908-1914.
.1999
;(127):1908-1914
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63. |
1999
Lin WW, Chen BC, Hsu YW, Lee CM and Shyue SK.
Modulation of inducible nitric oxide synthase induction by prostaglandin E2 in macrophages: distinct susceptability in murine J774 and RAW 264.7 macrophages.
. Prostaglandins other Lipid Mediators
.1999
;(58):87-101
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64. |
1999
Chen BC, Lin LL and Lin WW.
PKCe dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipaseA2 in endothelial cells.
. European Journal of Pharmacology
.1999
;(373):101-110
|
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65. |
1999
Chen BC, Chen YH and Lin WW.
Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages.
. Immunology
.1999
;(97):124-129
|
|
66. |
1999
Lin WW and Chen BC.
Induction of cyclooxygenase-2 expression by methyl arachidonyl fluorophosphonate in murine J774 macrophages: role of protein kinase C, ERKs and p38 MAPK.
. British Journal of Pharmacology 126: 1419-1425.
.1999
;(126):1419-1425
|
|
67. |
1998
Lin W W and Chen BC.
Distinct PKC isoforms mediate the activation of cPLA2 and adenylyl cyclase by phorbol ester in RAW 264.7 macrophages.
. British Journal of Pharmacology
.1998
;(125):1601-1609
|
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68. |
1998
Chen BC, Chou CF and Lin WW.
Pyrimidinoceptor-mediated potentiation of inducible nitric-oxide synthase induction in J774 macrophages: role of intracellular calcium.
. Journal of Biological Chemistry
.1998
;(273):29754-29763
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69. |
1998
Lin WW and Chen BC.
Pharmacological comparison of UTP- and thapsigargin-induced arachidonic acid release in mouse RAW 264.7 macrophages.
. British Journal of Pharmacology
.1998
;(123):1173-1181
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70. |
1997
Lin WW and Chen BC.
Involvement of protein kinase C in the UTP-mediated potentiation of cyclic AMP accumulation in mouse J774 macrophages.
. British Journal of Pharmacology
.1997
;(121):1749-1457
|
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71. |
1997
Chen BC and Lin WW.
Inhibition of ecto-ATPase by the P2 purinoceptor agonists, ATPgS, a,b-methylene ATP and AMP-PNP, in endothelial cells.
. Biochemical and Biophysical Research Communication 233: 442-446.
.1997
;(233):442-446
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72. |
1996
Chen BC, Lee CM and Lin WW.
Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages.
. British Journal of Pharmacology
.1996
;(119):1628-1634
|
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73. |
1996
Chen BC, Lee CM, Lee YT and Lin WW.
Characterization of signaling pathways of P2Y and P2U purinoceptors in bovine pulmonary artery endothelial cells.
. Journal of Cardiovascular Pharmacology
.1996
;(28):192-199
|
|