楊維中(YANG WEI-CHUNG)　教授

Email
vyang@tmu.edu.tw
現   職
轉譯醫學博士學位學程 教授

學經歷

學　歷

畢業學校與學位[修業時間]
美國德州大學生物醫學研究所 博士
1995/08/01~1999/06/01

本校學術經歷

任職單位與職稱[起迄時間]
轉譯醫學博士學位學程教授
2025/02/01~
轉譯醫學博士學位學程教授
2013/08/01~
轉譯醫學博士學位學程副教授
2012/08/01~2013/07/31
轉譯醫學博士學位學程籌備處副教授
2012/02/01~2012/07/31
醫學檢驗暨生物技術學系副教授
2011/09/01~2012/01/31
生醫材料暨組織工程研究所(舊)副教授
2011/08/01~2011/08/31
生醫材料暨工程研究所(舊)副教授
2007/08/01~2011/07/31
生物醫學材料研究所副教授
2006/08/01~2007/07/31
生物醫學材料研究所助理教授
2001/08/01~2006/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際轉譯科學碩士學位學程教授
2024/05/01 ~
(舊)國際轉譯科學博士學位學程籌備處教授
2020/05/01 ~
醫學資訊研究所教授
2017/03/01 ~
(舊)生技醫療產業研發博士學位學程教授
2016/08/01 ~ 2017/07/31
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程
2013/08/01 ~
轉譯醫學博士學位學程主任
2012/08/01 ~ 2018/07/31
轉譯醫學博士學位學程籌備處主任
2011/09/01 ~ 2012/07/31
轉譯醫學研究中心(舊)執行長
2010/02/01 ~
(舊)轉譯醫學研究中心執行長
2010/02/01 ~ 2016/10/20
牙醫學系副教授
2006/08/01 ~
神經科學研究所助理教授
2006/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院生物化學研究所博士後研究員
1999/12/01~2001/07/31

專長與研究領域

學門領域
婦產科
幹細胞/再生生物醫學
醫學工程
學術專長
Recombinant protein expression and purification
Cell culture and staining
molecular cloning
Liquid Chromatography
HPLC
Western blot
immunoprecipitation
ELISA
Solid phase binding assay
Circular Dichroism
Fluorescence Polarization
Carbohydrate Analysis

論文著作

清冊下載

論文 Journal Paper


1. 2023 Maximize the safety and efficacy of fertility preservation by random start/dual ovarian stimulation for early breast cancer patients . Taiwanese Journal of Obstetrics & Gynecology .2023 ;(62):330-333

2. 2023 Potential candidate gene and underlying molecular mechanism involving in tumorigenesis of endometriosis-associated ovarian cancer (EAOC) in Asian populations . Medical Science Forum .2023 ;(20):1-7

3. 2023 Heterogeneity of Alzheimer’s disease identified by neuropsychological test profiling . PLoS ONE .2023 ;(18):1-16

4. 2021 Chen, S-Y,Chang, T-C,Lin, C-Y,Lai, C-H,Wu, R-C,Yang, L-Y, Chang, W-Y, Lee, Y-S, Yang, W-C V, Chao, A. Serum levels of alpha1-antitrypsin isoforms in patients with ovarian clear cell carcinoma: An exploratory study . Journal of the Chinese Medical Association .2021 ;(84):1048-1053

5. 2020 Yadav VK,Lee T-Y,Hsu J B-K,Huang H-D,Yang W-C V,Chang T-H. Computational analysis for identification of the extracellular matrix molecules involved in endometrial cancer progression . Plos One .2020 ;(15):1-21

6. 2019 Chii‐Ruey ,Yang W-C V,Tzeng C-R. Reply to: Adhesion proteins: Suitable therapeutic targets or biomarkers of therapy response for endometriosis? . Acta Obstetricia et Gynecologica Scandinavica .2019 ;(98):812

7. 2019 Rahmawati E.,Yang, W-C V. ,Lei, Y-P,Maurya, P. K. ,Chen, H-W,Tzeng, C-R. Decreased Level of Neurotrophic Factor Neuritin 1 in Women with Ovarian Endometriosis after Receiving Gonadotropin-Releasing Hormone Agonist Treatment . Int. J. Mol. Sci. .2019 ;(20):4352-4367

8. 2018 Endah Rahmawati,Wei-Chung V. Yang,Yen‐Ping Lei,Pawan K. Maurya,Huei‐Wen Chen,Chii‐Ruey Tzeng. Gonadotropin‐releasing hormone agonist induces downregulation of tensin 1 in women with endometriosis . Acta Obstet Gynecol Scand. .2018 ;(98):222-31

9. 2018 Huang Hsin Yi ,Wang Ming Chen ,Chen Zhi Yu ,Chiu Wen Ying ,Chen Ko Hua ,Lin IC, Yang WCV, Wu CC, Tzeng CL. Gelatin–epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief . International Journal of Nanomedicine .2018 ;(13):7251-7273

10. 2017 Iqbal U ,Chang TH,Nguyen PA,Syed-Abdul S ,Yang HC,Huang CW, Atique S, Yang WC, Moldovan M, Jian WS, Hsu MH, Yen Y, Jack Li YC. Benzodiazepines use and breast cancer risk: A population-based study and gene expression profiling evidence . Journal of Biomedical Informatics .2017 ;(74):85-91

11. 2016 Chang S-C,Yang W-C V. Hyperglycemia, Tumorigenesis, and Chronic Inflammation . Crit Revs Oncol Hemat .2016 ;(108):146-153

12. 2014 Syed-Abdul S,Nguyen A,Huang F,Jian W-S,Iqbal U,Yang V, Hsu M-H, Li Y-C. A Smart Medication Recommendation Model for The Electronic Prescription. . Comput Methods Programs Biomed .2014 ;(117):218-224

13. 2013 Chang, SH,Yang, W-C V.. Hyperglycemia induces altered expressions of angiogenesis associated molecules in the trophoblast . Evidence-Based Complementary and Alternative Medicine .2013 ;(1):1-11

14. 2012 Shih Y-H,Yang J-C,Li S-H,Yang W-C V.,Chen C-C. Bio-electrospinning of poly(l-lactic acid) hollow fibrous membrane . Textile Research Journal .2012 ;(82):602-612

15. 2012 Lee S-Y,Huang G-W,Shiung J-N,Huang Y-H,Jeng J-H,Kuo T-F, Yang J-C, Yang W-C V*. Magnetic cryopreservation for dental pulp stem cells . Cells Tissues Organs .2012 ;(196):23-33

16. 2012 Lee S-Y S,Su C-H B,Kuo T-F,Huang Y-H,Jeng J-H,Yang J-C, Yang W-C V. Determination of cryoprotectant for magnetic cryopreservation of dental pulp tissue . Tissue Engineering Part C: Methods .2012 ;(18):397-407

17. 2012 Lin LC,Yeh CT,Kuo CC,Lee CM,Yen GC,Wang LS, Wu CH, Yang WC, Wu ATH. Sulforaphane Potentiates the Efficacy of Imatinib against Chronic Leukemia Cancer . J Agric Food Chem .2012 ;(60):7031-7039

18. 2010 Wu, J-Y,Yi, C,Chung, H-R,Wang, D-J,Chang, W-C,Lee, S-Y, Lin, C-T, Yang, Y-C, Yang, W-C V*. Potential biomarkers in saliva for oral squamous cell carcinoma . Oral Oncology .2010 ;(46):226-231

19. 2010 Yang, W-C V,Chung, H-R,Wu, J-Y,Yi, C,Wang, D-J,Lee, S-Y. Biomarkers of oral cytology for oral squamous cell carcinoma . Journal of Dental Science .2010 ;(5):60-69

20. 2008 Lin HC,Yang WCV,Lee HC. Traditional Chinese medicine usage among schizophrenia patients . Complementary Therapies in Medicine .2008 ;(16):336-342

21. 2008 Liu WL,Lee YH,Tsai SY,Hsu CY,Sun YY,Yang LY, Tsai SH, Yang WCV*. Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes . Glia .2008 ;(56):1390-1400

22. 2008 Chang YC,Wang DJ,Lee SY,Yang WCV*. Effect of calcium sulfate on osteopontin expression in U-2 osteosarcoma cells . Journal of Dental Science .2008 ;(3):30-37

23. 2007 Chen CP,Chang SC,Yang WCV*. High glucose alters proteoglycan expression and the glycosaminoglycan composition in placentas of women with gestational diabetes mellitus and in cultured trophoblasts . Placenta .2007 ;(28):97-106

24. 2006 Dugan TA,Yang VWC,McQuillan JD,Hook M. Decorin modulates fibrin assembly and structure. . Journal of Biological Chemistry .2006 ;(281):38208-38216

25. 2005 Yang WCV,Su TH,Yang YC,Chang SC,Chen CY,Chen CP. Perlecan Expression in Placental Development and Gestational Diabetes Mellitus . Placenta .2005 ;(26):780-788

26. 2005 Yang WCV,Au HK,Chang CW,Chen HW,Chen PH,Chen CC, Tang YL, Wang IT, Tzeng CR. Matrix remodeling and endometriosis . Reproductive Medicine and Biology .2005 ;(4):93-99

27. 2005 Yeh TS,Ho JD,Yang VWC,Tzeng CR,Hsieh RH. Calcium stimulates mitochondrial biogenesis in human granulosa cells . Annals of the New York Academy of Sciences .2005 ;(1042):1-6

28. 2004 Yang WCV,Chen HW,Au HK,Chang CW,Huang CT,Yen YH, Tzeng CR.. Endometriosis: Serum and Endometrial Markers. . Best Practice & Research Clinical Obstetrics & Gynaecology .2004 ;(18):305-318

29. 2003 Dugan TA,Yang WCV,McQuillan JD,Höök M. Decorin Binds Fibrinogen in a Zn2+-dependent interaction . Journal of Biological Chemistry .2003 ;(278):13655-13662

30. 1999 Yang, V. W-C, LaBrenz, S., Rosenberg, L., McQuillan, D., and Hook, M.. Decorin is a Zn2+ Metalloprotein . J. Biol. Chem. .1999 ;(274):12454-12460

31. 1999 Rich, R. L., Narayana, S. V. L., Owens, R. T., Carson, M., Hook, A., Yang, W-C, Deivanayagam, C. C. S., and Hook, M.. Collagen binding by the human a1 integrin I domain and the S. aureus collagen binding protein MSCRAMM. . J. Biol. Chem. .1999 ;(274):24906-24913

會議論文 Conference Paper


1. 2009 Yang, W-C V. Preservation of the essential extracellular matrix environment for dental tissue repair . The first workshop for Bio-dental education and research, Hiroshima, Japan, Feb. 7-8. 2009 .2009

2. 2009 Yi, S-E,Wang, H-L,Chen, S-T,Tzeng, C-R,Wang, A H-J,Yang, W-C V*. A new serum marker for endometriosis . The 7th Conference of the Pacific Rim Society for Fertility and Sterility & Annual Meeting of the Taiwanese Society for Reproductive Medicine .2009

3. 2008 Yang WCV,Chang YW,Chen HW,Tzeng CR. Increased expression of SPARC in patients with endometriosis . 10th World Congress on Endometriosis .2008

4. 2008 Yang WCV,Tung SY,Liu WL,Lee YH,Hung YH. Activities of human perlecan derived peptides in laminin-mediated cell adhesion and neurite outgrowth . 8th World Biomaterials Congress .2008

5. 2006 Liu WL,Sun YY,Chou CM,Lee YH,Hsu CY,Yang WCV*. Glucocorticoid downregulate the expression of chondroitin sulfate proteoglycan neurocan in reactive astrocytes. . 2006 International Symposium on Stroke Research .2006

6. 2006 Chang YW,Au HK,Chen PH,Tzeng CR,Yang WCV*. Study of the correlation of Chlamydia trachomatis infection and endometriosis . Taiwanese Society for Reproductive Medicine Annual Meeting .2006

7. 2005 Yang VWC,Chen HW,Huang YJ,Chen CS,Chen PH,Tzeng CR. Altered extracellular atrix in eutopic and ectopic endometrium of endometriosis. . Fertility and Sterility .2005 ;(84):S122

8. 2004 Yang VWC*,Liu WL,Tsai SY,Hsu CY,Chueh CC,Lee YH. Methylprednisolone Regulates Expressions of Inhibitory Extracellular Matrix Molecules in Astrocytes. . 2004 Neuroscience .2004

9. 2004 Yang VWC,Huang YJ,Wang AHJ,Tzeng CR. Identification of Serum Markers for Endometriosis – A Proteomic Approach. . Fertility and Sterility .2004 ;(82):S165

10. 2004 Yang VWC*,Chang SC,Liu WL. Effect of Proteoglycans on the Differentiation of ATDC5 Cells to Chondrocytes. . The 7th World Biomaterials Congress, 2004 .2004

11. 2003 Yang WCV*,Lee WC,Tzeng CR. Matrix Metalloproteinase and the Tissue Inhibitor of Metalloproteinase Expression in Sera of Women with Endometriosis before and after Gonadotropin-Releasing Hormone Analog Therapy . Annual Meeting of the American Society for Reproductive Medicine .2003 ;(P262)

12. 2002 Chen, HW, Lee, HN, Chen, JJW, Yang, VWC, Yu, SL, Tzeng,. Idetification of endometriosis-related genes by cDNA microarray . Fertility & Sterility .2002 ;(78):S199

13. 2002 Chen HW, Yang VWC, Lee HN, Chen JJW, and Tzeng CR. The differentially expressed genes in eutopic endometrium with or without endometriosis and in ectopic endometrium following GnRH-analog treatment . .2002

14. 2002 Lee WC,Tzeng CR,Yang WCV*. Differentiation Expression and Degradation of Extracellular Matrix in Women with Endometriosis before and after Gonadotropin-Releasing Hormone Analog Therapy. . The 3rd Conference of the Pacific Rim Society for Fertility and Sterility & Annual Meeting of TSRM 2002 .2002

15. 2000 Sadako Inoue, Vivian Wei-Chung Yang, Shu-Ling Lin, Yaseo Inoue.. Chemical Analysis of the Developmental Pattern of Polysialylation in Chicken Brain. . .2000

16. 1998 Vivian Wei-Chung Yang, Steven R. LaBrenz, Lawrence C. Rosenberg, Magnus Hook.. Decorin - A Zinc Binding Protein. . .1998

技術論文 Technical Report


1. 2009 楊維中*. 利用生物標記作為疾病診斷、追蹤、及預後之策略 . 生技研發成果產業化季刊 .2009

書籍 Book


1. 2004 Yang, V. W-C,Chen, H-W,Au, H-K,Chang, C-W,Huang, C-T,Yen, Y-H, Tzeng, C-R.. Endometriosis: Serum and Endometrial Markers. . Best Practice & Research Clinical Obstetric and Gyncology, Oxford. .2004

專利 Patent


1. 2018 Yang WC,Wang HJ,Chen ST,Lu KF,Peng MC. Specific A1AT Monoclonal Antibodies For Detection Of Endometriosis, . EP2663865 .2018

2. 2016 Yang WC,Wang HJ,Chen ST,Lu KF,Peng MC. 用以检测子宫内膜异位的专一性A1AT单克隆抗体 . 中華人民共和國國家知識產權局 .2016

3. 2016 Yang WC,Wang HJ,Chen ST,Lu KF,Peng MC. Specific monoclonal antibodies for detection of endometriosis . .2016

4. 2016 楊維中,王惠鈞,陳水聰,呂肯奮,彭明棋. 用以偵測子宮內膜異位之專一性A1AT單株抗體 . .2016

5. 2014 Yang WC,Yang JC,Wang DJ,Lee SY,Chen YJ. 聚乳酸/硫酸鈣支架 . .2014

6. 2014 Yang, WCV,Yang, JC,Wang, DJ,Lee, SY,Chen, YC. AN POLYLACTIC ACID/CALCIUM SULFATE SCAFFOLD . .2014

7. 2009 楊維中,曾啟瑞,王惠鈞. 利用檢知生化標記之子宮內膜異位症檢測方法與生化標記的使用 . .2009 ;(I 3058)

8. 2008 Yang WC,Tzeng CR,Wang AHJ. Diagnosis Method of Endometriosis by Detecting Biochemical Markers and Usage of these Biochemical Markers . US7399598 .2008

9. 2006 賴文福,鄧文炳,蔡郁惠,陳榮邦,楊維中,威靈頓.潘. 再生性骨植入物 . .2006

10. 2002 Yang WC,Magnus H. MD4 peptide, an anticoagulant inhibits fibrin clot formation. . US6413931 .2002

11. 2000 Yang, V. W-C,Hook, M. Peptide inhibitor of fibrinogen blood clotting, US6413931 . .2000 ;(WO0068)

其它 Other


1. 1999 Yang, V. W-C. Interactions and Structural Analysis of the Zinc Binding Motif in Decorin, a Small Leucince Rich Repeat Proteoglycan in Extracellular Matrix . .1999

研究計畫

計畫名稱
105 探討高尿酸血症(痛風)病人與日後罹患阿茲海默症疾病風險的相關性研究
補助單位
科技部
計畫名稱
104 子宮內膜異位症體外血清診斷試劑開發計畫(1/2)
補助單位
科技部
計畫名稱
104 子宮內膜異位症體外血清診斷試劑開發計畫(2/2)
補助單位
科技部
計畫名稱
102 一種子宮內膜異位症體外診斷試劑臨床前及臨床(評估)試驗計畫(2/2)
補助單位
行政院國家科學委員會
計畫名稱
102 一種子宮內膜異位症體外診斷試劑臨床前及臨床(評估)試驗計畫(2-2)
補助單位
科技部
計畫名稱
101 一種子宮內膜異位症體外診斷試劑臨床前及臨床(評估)試驗計畫(1/2)
補助單位
行政院國家科學委員會
計畫名稱
100 於脊髓損傷動物模式中探討蛋白多醣對於神經軸突生長與功能性回復之影響
補助單位
行政院國家科學委員會
計畫名稱
99 子宮內膜異位症免疫診斷試劑開發計畫
補助單位
行政院衛生署
計畫名稱
98 探討珍珠素蛋白多醣在脊椎損傷後對於神經纖維再生的影響
補助單位
行政院國家科學委員會
計畫名稱
97 子宮內膜異位症血清診斷套組之開發
補助單位
行政院衛生署
計畫名稱
96 探討中樞神經系統受傷後活化態星形膠細胞中膠質原纖維酸性蛋白對於硫化軟骨多醣表現之調控機轉研究
補助單位
行政院國家科學委員會
計畫名稱
96 探討珍珠素蛋白多醣在脊椎損傷後對於神經纖維再生的影響
補助單位
行政院國家科學委員會
計畫名稱
95 以細胞培養模式探討蛋白多醣在中樞神經系統受傷後的神經纖維再生的影響
補助單位
行政院國家科學委員會
計畫名稱
94 披衣菌感染和子宮內膜異位症的相關性
補助單位
臺北醫學大學附設醫院
計畫名稱
94 蛋白多醣在脊椎受傷後之表現及其分子調控機轉之研究
補助單位
行政院國家科學委員會
計畫名稱
93 探討蛋白多醣對誘導小鼠胚胎幹細胞分化為軟骨細胞之影響及作用機轉
補助單位
行政院國家科學委員會
計畫名稱
92 探討變異性蛋白質及醣質於子宮內膜異位症之表現
補助單位
行政院國家科學委員會
計畫名稱
92 植物性蛋白醣在組織修復之應用
補助單位
行政院國家科學委員會
計畫名稱
92 蛋白醣對於成骨細胞黏連之研究
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
91 探討細胞外質分子之表現與子宮內膜異位症病程發展的關聯性之研究
補助單位
行政院國家科學委員會
計畫名稱
90 台灣本土農作物中可促進傷口癒合之醣質成分之萃取，分析與生物活性之確立與探討
補助單位
行政院農委會農糧處園產科