| 1. |
2024
Tu HJ,Chao MW,Lee CC,Peng CS,Wu YW,Lin TE, Chang YW, Yen SC, Hsu KC, Pan SL*, HuangFu WC*..
Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation.
. J Enzyme Inhib Med Chem
.2024
;(39):2418470-2418477
|
|
| 2. |
2024
Shih WH,Huang HL,HuangFu WC,Lin TE,Sung TY,Li MC, Huang GL, Chang YW, Yen SC, Hsieh HP, Hsu KC*, Pan SL*.
Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma.
. Int J Biol Macromol.
.2024
|
|
| 3. |
2024
Wu Yi Wen,HuangFu Wei Chun,Lin Tony Eight,Peng Chao Hsiang,Tu Huang Ju,Sung Ting Yi,Sung Tzu Ying,Yen Shih Chung,Pan Shiow Lin,Hsu Kai Cheng,Wu Yi Wen,HuangFu Wei Chun,Lin Tony Eight,Peng Chao Hsiang,Tu Huang Ju,Sung Ting Yi,Sung Tzu Ying,Yen Shih Chung,Pan Shiow Lin,Hsu Kai Cheng.
Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule
. International Journal of Biological Macromolecules
.2024
;(259)
|
|
| 4. |
2024
Huang Cheng Chiao,Hsu Chia Ming,Chao Min Wu,Hsu Kai Cheng,Lin Tony Eight,Yen Shih Chung,Tu Huang Ju,Pan Shiow Lin,Huang Cheng Chiao,Hsu Chia Ming,Chao Min Wu,Hsu Kai Cheng,Lin Tony Eight,Yen Shih Chung,Tu Huang Ju,Pan Shiow Lin.
In silico identification of a novel Cdc2-like kinase 2 (CLK2) inhibitor in triple negative breast cancer
. Protein Science
.2024
;(33)
|
|
| 5. |
2023
Chang CD, Chao MW, Lee HY, Liu YT, Tu HJ, Lien ST, Lin TE, Sung TY, Yen SC, Huang SH, Hsu KC, Pan SL*. In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer.
. J Enzyme Inhib Med Chem.
.2023
;(38):2166039-2166049
|
|
| 6. |
2023
Tu HJ,Su CJ,Peng CS,Lin TE,HuangFu WC,Hsu KC, Hwang TL*, Pan SL*.
Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity.
. J Food Drug Anal.
.2023
|
|
| 7. |
2022
Lin TE, Chao MW, HuangFu WC, Tu HJ, Peng ZX, Su CJ, Sung TY, Hsieh JH, Lee CC, Yang CR, Pan SL, Hsu KC. Identification and analysis of a selective DYRK1A inhibitor.
. Biomed Pharmacother.
.2022
|
|
| 8. |
2022
Yen SC, Chen LC, Huang HL, HuangFu WC, Chen YY, Eight Lin T, Lien ST, Tseng HJ, Sung TY, Hsieh JH, Huang WJ, Pan SL, Hsu KC.
. Bioorg Chem.
.2022
|
|
| 9. |
2022
Yen SC, Wu YW, Huang CC, Chao MW, Tu HJ, Chen LC, Lin TE, Sung TY, Tseng HJ, Chu JC, Huang WJ, Yang CR, HuangFu WC, Pan SL*, Hsu KC*. O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia.
. Phytomedicine
.2022
;(100):154061-154071
|
|
| 10. |
2021
Yen SC,Chen LC,Huang HL,Ngo ST,Wu YW,Lin TE, Sung TY, Lien ST, Tseng HJ, Pan SL, Huang WJ, Hsu KC.
Yen SC, Chen LC, Huang HL, Ngo ST, Wu YW, Lin TE, Sung TY, Lien ST, Tseng HJ, Pan SL, Huang WJ, Hsu KC. Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
. J Nat Prod.
.2021
;(84):1-10
|
|
| 11. |
2021
Sung TY,Huang HL,Cheng CC,Chang FL,Wei PL,Cheng YW, Huang CC*, Lee YC*, HuangFu WC*, Pan SL*. .
Sung TY, Huang HL, Cheng CC, Chang FL, Wei PL, Cheng YW, Huang CC*, Lee YC*, HuangFu WC*, Pan SL*. EGFL6 promotes colorectal cancer cell growth and mobility and the anti-cancer property of anti-EGFL6 antibody.
. Cell Biosci.
.2021
;(11):53-63
|
|
| 12. |
2021
Liu YM,Tu HJ,Wu CH,Lai MJ,Yu SC,Chao MW, Wu YW, Teng CM, Pan SL*, Liou JP*. .
Liu YM, Tu HJ, Wu CH, Lai MJ, Yu SC, Chao MW, Wu YW, Teng CM, Pan SL*, Liou JP*. Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo.
. Eur J Med Chem.
.2021
;(219):113428-113438
|
|
| 13. |
2021
Wu YW,Chao MW,Tu HJ,Chen LC,Hsu KC,Liou JP, Yang CR, Yen SC, HuangFu WC*, Pan SL*..
Wu YW, Chao MW, Tu HJ, Chen LC, Hsu KC, Liou JP, Yang CR, Yen SC, HuangFu WC*, Pan SL*. A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo.
. Oncogenesis
.2021
;(10):39-50
|
|
| 14. |
2021
Chang TY,Nepali K,Chen YY,Yang YSH,Hsu KC,Yen Y, Pan SL, Liou JP, Lee SB..
Chang TY, Nepali K, Chen YY, Yang YSH, Hsu KC, Yen Y, Pan SL, Liou JP, Lee SB. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling.
. Biomed Pharmacother.
.2021
;(138):111485-111495
|
|
| 15. |
2021
Chao MW,Lin TE,HuangFu WC,Chang CD,Tu HJ,Chen LC, Yen SC, Sung TY, Huang WJ, Yang CR, Pan SL, Hsu KC..
Chao MW, Lin TE, HuangFu WC, Chang CD, Tu HJ, Chen LC, Yen SC, Sung TY, Huang WJ, Yang CR, Pan SL, Hsu KC. Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach.
. J Enzyme Inhib Med Chem
.2021
;(36):98-108
|
|
| 16. |
2020
Mehndiratta S,Lin MH ,Wu YW,Chen CH,Wu TY ,Chuang KH, Chao MW, Chen YY, Pan SL, Chen MC, Liou JP.
Mehndiratta S, Lin MH, Wu YW, Chen CH, Wu TY, Chuang KH, Chao MW, Chen YY, Pan SL, Chen MC, Liou JP*. Nanilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression.
. Eur J Med Chem.
.2020
;(185):111725
|
|
| 17. |
2020
Tseng HJ,Lin MH,Shiao YJ,Yang YC,Chu JC,Chen CY, Chen YY, Lin TE, Su CJ, Pan SL, Chen LC, Wang CY, Hsu KC, Huang WJ..
Tseng HJ, Lin MH, Shiao YJ, Yang YC, Chu JC, Chen CY, Chen YY, Lin TE, Su CJ, Pan SL, Chen LC, Wang CY, Hsu KC, Huang WJ*. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease.
. Eur J Med Chem.
.2020
;(192):112193
|
|
| 18. |
2020
Ojha R,Nepali K,Chen CH,Chuang KH,Wu TY,Lin TE, Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP..
Ojha R, Nepali K, Chen CH, Chuang KH, Wu TY, Lin TE, Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP*. Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo.
. Eur J Med Chem.
.2020
;(190):112086
|
|
| 19. |
2020
Lin CF,Hsu KC,HuangFu WC,Lin TE,Huang HL,Pan SL.
Lin CF, Hsu KC, HuangFu WC, Lin TE, Huang HL*, Pan SL*. Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury.
. BMC Pharmacol Toxicol.
.2020
;(21):21
|
|
| 20. |
2020
Chang FL,Tsai KC,Lin TY,Yang TW,Lo YN,Chen WC, Chang JH, Lu MK, Chiou CT, Chen PH, Yen Y*, Pan SL*, Lee YC*..
Chang FL, Tsai KC, Lin TY, Yang TW, Lo YN, Chen WC, Chang JH, Lu MK, Chiou CT, Chen PH, Yen Y*, Pan SL*, Lee YC*. Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors.
. Biomed Res Int.
.2020
;(2020):3415471
|
|
| 21. |
2020
Lee YC,Huang HT,Chang CD,Chen CT,Lin TY,Yang TW, Chang FL, Lu MK, Chiou CT, Chen WC, Pan SL, Tsai KC.
Lee YC, Huang HT, Chang CD, Chen CT, Lin TY, Yang TW, Chang FL, Lu MK, Chiou CT, Chen WC, Pan SL, Tsai KC. Isolation of anti-VEGF monoclonal antibodies with neutralizing effects from an Astragalus-induced immune antibody library.
. Int Immunopharmacol.
.2020
;(88):107007
|
|
| 22. |
2020
Chen LC,Huang HL,HuangFu WC,Yen SC,Ngo ST,Wu YW, Lin TE, Sung TY, Lien ST, Tseng HJ, Pan SL, Huang WJ, Hsu KC..
Chen LC, Huang HL, HuangFu WC, Yen SC, Ngo ST, Wu YW, Lin TE, Sung TY, Lien ST, Tseng HJ, Pan SL, Huang WJ, Hsu KC. Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia.
. J Nat Prod.
.2020
;(83):2967-2975
|
|
| 23. |
2020
Wu WC,Liu YM,Liao YH,Hsu KC,Lien ST,Chen IC, Lai MJ, Li YH, Pan SL, Chen MC, Liou JP. .
Wu WC, Liu YM, Liao YH, Hsu KC, Lien ST, Chen IC, Lai MJ, Li YH, Pan SL, Chen MC, Liou JP. Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells.
. Eur J Med Chem.
.2020
;(203):112540-112550
|
|
| 24. |
2020
Hsu KC,HuangFu WC,Lin TE,Chao MW,Sung TY,Chen YY, Pan SL, Lee JC, Tzou SC, Sun CM, Yang JM..
Hsu KC, HuangFu WC, Lin TE, Chao MW, Sung TY, Chen YY, Pan SL, Lee JC, Tzou SC, Sun CM, Yang JM. A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors.
. Sci Rep.
.2020
;(10):10510-10520
|
|
| 25. |
2019
Hsieh YL,Tu HJ,Pan SL,Liou JP,Yang CR.
Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo.
. Biochim Biophys Acta Mol Cell Res
.2019
;(1866):992-1003
|
|
| 26. |
2019
MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells.
. Front Oncol.
.2019
;(9):249-258
|
|
| 27. |
2019
Lin CF, Su CJ, Liu JH, Chen ST, Huang HL*, Pan SL*. Potential effects of CXCL9 and CCL20 on cardiac fibrosis in patients with myocardial infarction.
. J. Clin. Med.
.2019
;(8):E659-E668
|
|
| 28. |
2019
Chao MW; Chang LH; Tu HJ; Chang CD; Lai MJ; Chen YY; Liou JP; Teng CM; Pan SL*. Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status.
. Clinical Epigenetics
.2019
;(11):85-94
|
|
| 29. |
2019
Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells.
. Bioorg Chem.
.2019
;(91):103119-103128
|
|
| 30. |
2019
Huang HL, Liu YM, Sung TY, Huang TC, Cheng YW, Liou JP*, Pan SL*. TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis.
. Theranostics
.2019
;(9):6676-6689
|
|
| 31. |
2018
Lin SY,Yeh TK,Song JS,Hung MS,Cheng MF,Liao FY, Li AS, Cheng SY, Lin LM, Chiu CH, Wu MH, Lin YJ, Hsiao W, Sun M, Wang YH, Huang CH, Tang YC, Chang HH, Huang ZT, Chao YS, Shih C, Pan SL, Wu SY, Kuo CC, Ueng SH. .
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.
. Bioorg Chem.
.2018
;(77):600-607
|
|
| 32. |
2018
Ojha R,Huang HL,HuangFu WC,Wu YW,Nepali K,Lai MJ, Su CJ, Sung TY, Chen YL, Pan SL, Liou JP..
1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC.
. Eur J Med Chem.
.2018
;(150):667-677
|
|
| 33. |
2018
Wu YW,Hsu KC,Lee HY,Huang TC,Lin TE,Chen YL, Sung TY, Liou JP, Hwang-Verslues WW, Pan SL, HuangFu WC..
A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo.
. Front Pharmacol.
.2018
;(9):205-210
|
|
| 34. |
2018
A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions.
. Front Pharmacol.
.2018
;(9):1379-1386
|
|
| 35. |
2018
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
. Clin Epigenetics.
.2018
;(10):162-170
|
|
| 36. |
2017
Liu YM,HuangFu WC,Huang HL,Wu WC,Chen YL,Yen Y, Huang HL, Nien CY, Lai MJ, Pan SL*, Liou JP..
1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma.
. Eur J Med Chem
.2017
;(140):84-91
|
|
| 37. |
2017
Chang HY,Ye SP,Pan SL ,Kuo TT,Liu BC,Chen YL, Huang TC.
Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer.
. Theranostics
.2017
;(7):3889-3900
|
|
| 38. |
2017
Chen MC,Kuo YC,Hsu CM,Chen YL,Shen CC,Teng CM, Pan SL*.
The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells.
. Sci Rep.
.2017
;(7):46149-46161
|
|
| 39. |
2017
Chao MW,Chen TH,Huang HL,Chang YW,HuangFu WC,Lee YC, Teng CM, Pan SL*.
Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells.
. Sci Rep.
.2017
;(7):46134-46145
|
|
| 40. |
2017
Mehndiratta S,Wang RS,Huang HL,Su CJ,Hsu CM,Wu YW, Pan SL, Liou JP.
4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo.
. Eur J Med Chem
.2017
;(134):13-23
|
|
| 41. |
2016
Mehndiratta S,Pan SL,Kumar S,Liou JP.
Indole-3-ethylsulfamoylphenylacrylamides with Potent Anti-proliferative and Anti-angiogenic Activities.
. Anticancer Agents Med Chem.
.2016
;(16):907-913
|
|
| 42. |
2016
Lin SY,Yeh TK,Kuo CC,Song JS,Cheng MF,Liao FY, Chao MW, Huang HL, Chen YL, Yang CY, Wu MH, Hsieh CL, Hsiao W,... Pan SL, Hung MS, Ueng SH..
Phenyl benzenesulfonylhydrazides exhibit selective indoleamine 2,3-dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy.
. J Med Chem.
.2016
;(59):419-430
|
|
| 43. |
2016
Chen CH,Liu YM,Pan SL,Liu YR,Liou JP,Yen Y.
Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo.
. Oncotarget
.2016
;(7):26374-26387
|
|
| 44. |
2016
Huang HL,Chao MW,Chen CC,Cheng CC,Chen MC,Lin CF, Liou JP, Teng CM, Pan SL.
LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo.
. Sci Rep.
.2016
;(6):27794
|
|
| 45. |
2016
Lin CF,Huang HL,Peng CY,Lee YC,Wang HP,Teng CM, Pan SL*.
TW-01, piperazinedione-derived compound, inhibits ras-mediated cell proliferation and angioplasty-induced vascular restenosis.
. Toxicol Appl Pharmacol
.2016
;(305):194-202
|
|
| 46. |
2016
Huang HL,Chao MW,Li YC,Chang LH,Chen CH,Chen MC, Cheng CC, Liou JP, Teng CM, Pan SL*.
MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer
. Sci Rep
.2016
;(6):31664-31672
|
|
| 47. |
2016
Wang HY,Chang YL,Cheng CC,Chao MW,Lin SI,Pan SL, Hsu CC, Liu TW, Cheng HC, Tseng CP, Liu SJ, Tsai HJ, Chang HY, Hsu TA.
Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer
. Oncotarget
.2016
;(7):85917-85928
|
|
| 48. |
2015
Chen CH,Lee CH,Liou JP,Teng CM,Pan SL.
Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acrylamide in human colorectal cancer cells in vitro and in vivo.
. Oncotarget.
.2015
;(6):35991-36002
|
|
| 49. |
2015
Huang HL,Peng CY,Lai MJ,Chen CH,Lee HY,Wang JC, Liou JP, Pan SL, Teng CM..
Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo.
. Oncotarget
.2015
;(6):4976-4991
|
|
| 50. |
2015
Liu YM,Lee HY,Chen CH,Lee CH,Wang LT,Pan SL, Lai MJ, Yeh TK, Liou JP..
1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells.
. Eur J Med Chem.
.2015
;(89):320-330
|
|
| 51. |
2015
Pai HC,Kumar S,Shen CC,Liou JP,Pan SL,Teng CM.
MT-4 Suppresses Resistant Ovarian Cancer Growth through Targeting Tubulin and HSP27
. PLoS One
.2015
;(10):e01238
|
|
| 52. |
2015
Tzeng HE,Yang L,Chen K,Wang Y,Liu YR,Pan SL, Gaur S, Hu S, Yen Y..
The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor.
. Oncotarget
.2015
;(6):11061-11073
|
|
| 53. |
2015
Szu-Ying Wu,Ping-Jyun Sung,Ya-Ling Chang,Shiow-Lin Pan,Che-Ming Teng.
Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis, and Autophagy in Human Renal Carcinoma Cells
. BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology)
.2015
;(2015):738241-738253
|
|
| 54. |
2015
Chao MW,Lai MJ,Liou JP,Chang YL,Wang JC,Pan SL, Teng CM..
The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo.
. J Hematol Oncol.
.2015
;(8):82
|
|
| 55. |
2015
Chao MW,Wang LT,Lai CY,Yang XM,Cheng YW,Lee KH, Pan SL, Teng CM..
eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer.
. Oncotarget
.2015
;(6):24092-24107
|
|
| 56. |
2015
Lai MJ,Lee HY,Chuang HY,Chang LH,Tsai AC,Chen MC, Huang HL, Wu YW, Teng CM, Pan SL, Liu YM, Mehndiratta S, Liou JP..
N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling.
. J Med Chem
.2015
;(58):6549-6558
|
|
| 57. |
2015
Liu YM,Lee HY,Lai MJ,Pan SL,Huang HL,Kuo FC, Chen MC, Liou JP..
Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells.
. Org Biomol Chem.
.2015
;(13):10226-10235
|
|
| 58. |
2014
Chen CH,Chen MC,Wang JC,Tsai AC,Chen CS,Liou JP*, Pan SL*, Teng CM*.
Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo.
. Clin Cancer Res
.2014
;(20):1274-1287
|
|
| 59. |
2014
Hsu JL,Lee YJ,Leu WJ,Dong YS,Pan SL,Uang BJ, Guh JH..
Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione-involved DNA damage response and mitochondrial stress in human hormone-refractory prostate cancers.
. J Urol.
.2014
;(191):1429-1438
|
|
| 60. |
2014
Tsai AC,Wang CY,Liou JP,Pai HC,Hsiao CJ,Chang JY, Wang JC, Teng CM, Pan SL*.
Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib.
. Cell Death Dis.
.2014
;(5):e1162
|
|
| 61. |
2014
Lee HY,Tsai AC,Chen MC,Shen PJ,Cheng YC,Kuo CC, Pan SL, Liu YM, Liu JF, Yeh TK, Wang JC, Chang CY, Chang JY, Liou JP.
Azaindolylsulfonamides, with a More Selective Inhibitory Effect on Histone Deacetylase 6 Activity, Exhibit Antitumor Activity in Colorectal Cancer HCT116 Cells.
. J Med Chem
.2014
;(57):4009-4022
|
|
| 62. |
2014
Yu CC,Pan SL,Chao SW,Liu SP,Hsu JL,Yang YC, Li TK, Huang WJ, Guh JH..
A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.
. Biochem Pharmacol.
.2014
;(90):320-330
|
|
| 63. |
2014
Wang MJ,Liu YQ,Chang LC,Wang CY,Zhao YL,Zhao XB, Qian K, Nan X, Yang L, Yang XM, Hung HY, Yang JS, Kuo DH, Goto M, Morris-Natschke SL, Pan S.
Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents.
. J Med Chem.
.2014
;(57):6008-18
|
|
| 64. |
2014
Wang LT,Liou JP,Li YH,Liu YM,Pan SL*,Teng CM*.
A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin.
. Oncotarget.
.2014
;(5):5651-62
|
|
| 65. |
2014
Wang CY,Liou JP,Tsai AC,Lai MJ,Liu YM,Lee HY, Wang JC, Pan SL*, Teng CM*.
A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulaiton of TIMP3 expression.
. Oncotarget
.2014
;(5):9838-9850
|
|
| 66. |
2014
Tsai AC,Pai HC,Wang CY,Liou JP,Teng CM,Wang JC, Pan SL.
In vitro and in vivo antitumor effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells
. British Journal of Pharmacology
.2014
;(171):122-133
|
|
| 67. |
2013
Lee HY,Pan SL,Su MC,Liu YM,Kuo CC,Chang YT, Wu JS, Nien CY, Mehndiratta S, Chang CY, Wu SY, Lai MJ, and Liou JP.
Furanylazaindoles: Potent Anticancer Agents in Vitro and in Vivo.
. J Med Chem
.2013
;(56):8008-8018
|
|
| 68. |
2013
Chen MC,Chen CH,Liu YN,Wang HP,Pan SL,Teng CM.
TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells.
. Cancer Lett.
.2013
;(336):370-378
|
|
| 69. |
2013
Lai CY,Pan SL,Yang XM,Chang LH,Chang YL,Yang PC, Lee KH, Teng CM..
Depletion of 4E-BP1 and regulation of autophagy lead to YXM110-induced anti-cancer effects.
. Carcinogenesis
.2013
;(34):2050-2060
|
|
| 70. |
2013
Chang LH,Pan SL,Lai CY,Tsai AC,Teng CM.
Activated PAR-2 Regulates Pancreatic Cancer Progression through ILK/HIF-α-Induced TGF-α Expression and MEK/VEGF-A-Mediated Angiogenesis.
. Am J Pathol
.2013
;(183):566-575
|
|
| 71. |
2013
Chen MC,Chen CH,Wang JC,Tsai AC,Liou JP,Pan SL, Teng CM.
The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells.
. Cell Death Dis
.2013
;(4):e810
|
|
| 72. |
2012
Pai HC,Chang LH,Peng CY,Chang YL,Chen CC,「Shen CC, Teng CM, Pan SL」.
Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway
. J Mol Med
.2012
|
|
| 73. |
2012
Wang LT,Pan SL,Chen TH,Dong YZ,Lee KH,「Teng CM」.
DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells
. Chembiochem
.2012
;(13):1663-1672
|
|
| 74. |
2012
Huang HL,Lee HY,Tsai AC,Peng CY,Lai MJ,「Wang JC, Pan SL, Teng CM, Liou JP」.
Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal CancerHCT116 Cells In Vitro and In Vivo
. PLoS One
.2012
;(7):e43645-e43656
|
|
| 75. |
2012
Chao MW,Chen CH,Chang YL,Teng CM,Pan SL.
α-Tomatine-mediated anti-cancer activity in vitro and in vivo through cell cycle- and caspase-independent pathways.
. PLoS One
.2012
;(7):e44093-e44093
|
|
| 76. |
2012
Lai CY,Tsai AC,Chen MC,Chang LH,Sun HL,Chang YL, Chen CC, Teng CM, Pan SL.
Aciculatin Induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo.
. PLoS One
.2012
;(7):e42192-e42192
|
|
| 77. |
2012
Yang X,Shi Q,Lai CY,Chen CY,Ohkoshi E,Yang SC,Wang CY, Bastow KF, Wu TS, Pan SL, Teng CM, Yang PC, Lee KH.
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
. J Med Chem
.2012
;(55):6751-61
|
|
| 78. |
2012
Wu SY,Leu YL,Chang YL,Wu TS,Kuo PC,Liao YR, Teng CM, Pan SL.
Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species.
. PLoS One
.2012
;(7):e40727-e40727
|
|
| 79. |
2012
Lo HM,Wu MW,Pan SL,Peng CY,Wu PH,Wu WB.
Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs.
. J Nutr Biochem
.2012
;(23):667-78
|
|
| 80. |
2012
Lai MJ,Huang HL,Pan SL,Liu YM,Peng CY,Lee HY, Yeh TK, Huang PH, Teng CM, Chen CS, Chuang HY, Liou JP.
Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.
. J Med Chem
.2012
;(55):3777-91
|
|
| 81. |
2012
Chen CH,Liao CH,Chang YL,Guh JH,Pan SL,Teng CM.
Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines.
. Cancer Lett
.2012
;(315):1-11
|
|
| 82. |
2012
Wang CY,Tsai AC,Peng CY,Chang YL,Lee KH,Teng CM, Pan SL.
Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.
. PLoS One
.2012
;(7):e31195-e31195
|
|
| 83. |
2012
Chen MC,Pan SL,Shi Q,Xiao Z,Lee KH,Li TK, Teng CM.
QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells.
. Cancer Sci
.2012
;(103):80-7
|
|
| 84. |
2011
Bai LY,Chiu CF,Pan SL,Sargeant AM,Shieh TM,Wang YC, Weng JR.
Antitumor activity of a novel histone deacetylase inhibitor (S)-HDAC42 in oral squamous cell carcinoma.
. Oral Oncol
.2011
;(47):1127-33
|
|
| 85. |
2011
Tsai AC,Pan SL,Lai CY,Wang CY,Chen CC,Shen CC, Teng CM.
The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling.
. J Nutr Biochem
.2011
;(22):625-33
|
|
| 86. |
2011
Yang X,Shi Q,Yang SC,Chen CY,Yu SL,Bastow KF, Morris-Natschke SL, Wu PC, Lai CY, Wu TS, Pan SL, Teng CM, Lin JC, Yang PC, Lee KH.
Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents.
. J Med Chem
.2011
;(54):5097-107
|
|
| 87. |
2011
Hsu JL,Pan SL,Ho YF,Hwang TL,Kung FL,Guh JH.
Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer.
. J Urol
.2011
;(185):1967-74
|
|
| 88. |
2011
Chang LH,Chen CH,Huang DY,Pai HC,Pan SL,Teng CM.
Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells.
. J Cell Physiol
.2011
;(226):1060-8
|
|
| 89. |
2010
Peng CY,Pan SL,Pai HC,Tsai AC,Guh JH,Chang YL, Kuo SC, Lee FY, Teng CM.
The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo.
. Shock
.2010
;(34):580-5
|
|
| 90. |
2010
Liu YN,Pan SL,Peng CY,Huang DY,Guh JH,Chen CC, Shen CC, Teng CM.
Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells.
. Shock
.2010
;(33):70-5
|
|
| 91. |
2010
Tsai AC,Pan SL,Liao CH,Guh JH,Wang SW,Sun HL, Liu YN, Chen CC, Shen CC, Chang YL, Teng CM.
Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo.
. Cancer Lett
.2010
;(292):163-70
|
|
| 92. |
2010
Dong Y,Shi Q,Pai HC,Peng CY,Pan SL,Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lee KH.
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
. J Med Chem
.2010
;(53):2299-308
|
|
| 93. |
2010
Tsai AC,Pan SL,Sun HL,Wang CY,Peng CY,Wang SW, Chang YL, Kuo SC, Kee KH, Teng CM.
CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation.
. J Biol Chem
.2010
;(285):5497-506
|
|
| 94. |
2010
Chiang PC,Lin SC,Pan SL,Kuo CH,Tsai IL,Kuo MT, Wen WC, Chen P, Guh JH.
Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.
. Biochem Pharmacol
.2010
;(79):162-71
|
|
| 95. |
2009
Liu YN,Pan SL,Liao CH,Huang DY,Guh JH,Peng CY, Chang YL, Teng CM.
Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7.
. Shock
.2009
;(32):263-9
|
|
| 96. |
2009
Sun HL,Tsai AC,Pan SL,Ding Q,Yamaguchi H,Lin CN, Hung MC, Teng CM.
EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation.
. Clin Cancer Res
.2009
;(15):4904-14
|
|
| 97. |
2009
Kuo CT,Chen BC,Yu CC,Weng CM,Hsu MJ,Chen CC, Chen MC, Teng CM, Pan SL, Bien MY, Shih CH, Lin CH.
Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells.
. J Biomed Sci
.2009
;(16):43
|
|
| 98. |
2008
Peng CY,Pan SL,Huang YW,Guh JH,Chang YL,Teng CM.
Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells.
. Naunyn Schmiedebergs Arch Pharmacol
.2008
;(378):579-88
|
|
| 99. |
2008
Chen TH,Pan SL,Guh JH,Chen CC,Huang YT,Pai HC, Teng CM.
Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells.
. Naunyn Schmiedebergs Arch Pharmacol
.2008
;(378):447-57
|
|
| 100. |
2008
Pan SL,Tao KY,Guh JH,Sun HL,Huang DY,Chang YL, Teng CM.
The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion.
. Shock
.2008
;(30):496-502
|
|
| 101. |
2008
Wu SY,Pan SL,Chen TH,Liao CH,Huang DY,Guh JH, Chang YL, Kuo SC, Lee FY, Teng CM.
YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway.
. Br J Pharmacol
.2008
;(155):505-13
|
|
| 102. |
2008
Liu YN,Pan SL,Peng CY,Huang DY,Guh JH,Kuo SC, Lee FY, Teng CM.
YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells.
. Shock
.2008
;(30):274-9
|
|
| 103. |
2008
Chen TH,Pan SL,Guh JH,Liao CH,Huang DY,Chen CC, Teng CM.
Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage.
. Clin Cancer Res
.2008
;(14):4250-8
|
|
| 104. |
2008
Peng CY,Pan SL,Lee KH,Bastow KF,Teng CM.
Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo.
. Cancer Lett
.2008
;(263):114-21
|
|
| 105. |
2008
Chiang PC,Hsu JL,Yeh TC,Pan SL,Guh JH.
Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma.
. Naunyn Schmiedebergs Arch Pharmacol
.2008
;(377):167-77
|
|
| 106. |
2008
Kuo CT,Hsu MJ,Chen BC,Chen CC,Teng CM,Pan SL, Lin CH.
Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction.
. Toxicol Lett
.2008
;(177):48-58
|
|
| 107. |
2008
Wang SW,Pan SL,Huang YC,Guh JH,Chiang PC,Huang DY, Kuo SC, Lee KH, Teng CM.
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
. Mol Cancer Ther
.2008
;(7):350-60
|
|