林乾閔(Chien-Min, Lin) 教授

Email
m513092004@tmu.edu.tw
現   職
外科學科 教授
臺北神經醫學中心 副院長

學經歷

學 歷

畢業學校與學位[修業時間]
臺北醫學大學臨床醫學研究所 博士
2006/09~2012/06
台北醫學大學傷害防治研究所 碩士
2004/09~2006/06
台北醫學大學醫學系 學士
1989/09~1996/06

本校學術經歷

任職單位與職稱[起迄時間]
外科學科教授
2021/02/01~
外科學科副教授
2016/02/01~2021/01/31
外科學科助理教授
2011/03/01~2016/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
臺北神經醫學中心副院長
2021/08/01 ~
臺北神經醫學中心副院長
2018/01/15 ~ 2020/12/09
(舊)神經再生醫學博士學位學程
2013/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
署立雙和醫院神經外科主治醫師
2008/06~
台北市立萬芳醫院神經外科主治醫師
2004/07~2008/08
台北醫學大學附設醫院主治醫師
1998/07~2004/07

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2023 I-Chang Su,Yu-Kai Su,Syahru Agung Setiawan,Vijesh Kumar Yadav,Iat-Hang Fong,Chi-Tai Yeh, Chien-Min Lin, Heng-Wei Liu. doi: 10.3390/ijms24097706. NADPH Oxidase Subunit CYBB Confers Chemotherapy and Ferroptosis Resistance in Mesenchymal Glioblastoma via Nrf2/SOD2 Modulation . International Journal of Molecular Sciences .2023 ;(24)

2. 2022 Hsu Bing Hung,Liu Heng Wei,Lee Kha Liang,Lin Ming Chin,Chen Gao,Yu Jang,Chen Chiao Ling,Su I. Chang,Lin Chien Min,Hsu Bing Hung,Liu Heng Wei,Lee Kha Liang,Lin Ming Chin,Chen Gao,Yu Jang,Chen Chiao Ling,Su I. Chang,Lin Chien Min. Learning Curve of ROSA ONE Spine System for Transpedicular Screw Placement . Neurospine .2022 ;(19):367-375

3. 2022 Lin Ming Chin,Liu Heng Wei,Su Yu Kai,Lo Wei Lun,Lin Chien Min,Lin Ming Chin,Liu Heng Wei,Su Yu Kai,Lo Wei Lun,Lin Chien Min. Robot-guided versus freehand fluoroscopy-guided minimally invasive transforaminal lumbar interbody fusion: a single-institution, observational, case-control study . Neurosurgical Focus .2022 ;(52)

4. 2022 Su I. Chang,Su Yu Kai,Chuang Hao Yu,Yadav Vijesh Kumar,Setiawan Syahru Agung,Fong Iat Hang,Yeh Chi Tai,Huang Hui Chuan,Lin Chien Min,Su I. Chang,Su Yu Kai,Chuang Hao Yu,Yadav Vijesh Kumar,Setiawan Syahru Agung,Fong Iat Hang,Yeh Chi Tai,Huang Hui Chuan,Lin Chien Min. Ubiquitin-Specific Protease 6 n-Terminal-like Protein (USP6NL) and the Epidermal Growth Factor Receptor (EGFR) Signaling Axis Regulates Ubiquitin-Mediated DNA Repair and Temozolomide-Resistance in Glioblastoma . Biomedicines .2022 ;(10)

5. 2022 Su I. Chang,Su Yu Kai,Chuang Hao Yu,Yadav Vijesh Kumar,Setiawan Syahru Agung,Fong Iat Hang,Yeh Chi Tai,Huang Hui Chuan,Lin Chien Min,Su I. Chang,Su Yu Kai,Chuang Hao Yu,Yadav Vijesh Kumar,Setiawan Syahru Agung,Fong Iat Hang,Yeh Chi Tai,Huang Hui Chuan,Lin Chien Min. Ubiquitin-Specific Protease 6 n-Terminal-like Protein (USP6NL) and the Epidermal Growth Factor Receptor (EGFR) Signaling Axis Regulates Ubiquitin-Mediated DNA Repair and Temozolomide-Resistance in Glioblastoma . Biomedicines .2022 ;(10)

6. 2022 Lin Ming Chin,Liu Heng Wei,Su Yu Kai,Lo Wei Lun,Lin Chien Min,Lin Ming Chin,Liu Heng Wei,Su Yu Kai,Lo Wei Lun,Lin Chien Min. Robot-guided versus freehand fluoroscopy-guided minimally invasive transforaminal lumbar interbody fusion: a single-institution, observational, case-control study . Neurosurgical Focus .2022 ;(52)

7. 2021 Yu Kai Su, ,Oluwaseun Adebayo Bamodu, ,I. Chang Su, ,Narpati Wesa Pikatan, ,Iat Hang Fong, ,Wei Hwa Lee, Chi Tai Yeh, Hsiao Yean Chiu, Chien Min Lin*.. Combined Treatment with Acalabrutinib and Rapamycin Inhibits Glioma Stem Cells and Promotes Vascular Normalization by Downregulating BTK/ mTOR/ VEGF Signaling. . Pharmaceuticals (Basel) .2021

8. 2020 Lin Chien Min,Lin Yi Tzu,Lee Tai Lin,Imtiyaz Zuha,Hou Wen Chi,Lee Mei Hsien,Lin Chien Min,Lin Yi Tzu,Lee Tai Lin,Imtiyaz Zuha,Hou Wen Chi,Lee Mei Hsien. In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland . Journal of Food and Drug Analysis .2020 ;(28):147-158

9. 2020 Su Yu Kai,Lin Jia Wei,Shih Jing Wen,Chuang Hao Yu,Fong Iat Hang,Yeh Chi-Tai,Lin Chien-Min,Su Yu Kai,Lin Jia Wei,Shih Jing Wen,Chuang Hao Yu,Fong Iat Hang,Yeh Chi-Tai,Lin Chien-Min*. Targeting BC200/miR218-5p Signaling Axis for Overcoming Temozolomide Resistance and Suppressing Glioma Stemness . Cells .2020 ;(9)

10. 2020 Liu Heng Wei,Lee Peter Mingjui,Bamodu Oluwaseun Adebayo,Su Yu Kai,Fong Iat Hang,Yeh Chi-Tai,Chien Ming-Hsien,Kan I-Hung,Lin Chien-Min,Liu Heng Wei,Lee Peter Mingjui,Bamodu Oluwaseun Adebayo,Su Yu Kai,Fong Iat Hang,Yeh Chi-Tai,Chien Ming-Hsien,Kan I-Hung,Lin Chien-Min. Correction to: Liu, h.w.; et al. enhanced hsa-mir-181d/p-stat3 and hsa-mir-181d/p-stat5a ratios mediate the anticancer effect of garcinol in stat3/5a-addicted glioblastoma. cancers 2019, 11, 1888 . Cancers .2020 ;(12):1-4

11. 2019 Yu-kai Su,Oluwaseun Adebayo Bamodu,Yew-Min Tzeng,Michael Hsiao,Chien-Min Lin*. Ovatodiolide Inhibits the Oncogenicity and Cancer Stem Cell-like Phenotype of Glioblastoma Cells, as well as Potentiate the Anticancer Effect of Temozolomide. . Phytomedicine .2019

12. 2019 Hao-Yu Chuang, ,Yu-kai Su, ,Heng-Wei Liu,Chao-Hsuan Chen, ,Shao-Chih Chiu,,Der-Yang Cho, Shinn-Zong Lin, Yueh-Sheng Chen, and Chien-Min Lin*. Preclinical Evidence of STAT3 Inhibitor Pacritinib Overcoming Temozolomide Resistance via Downregulating miR-21-Enriched Exosomes from M2 Glioblastoma-Associated Macrophages. . Journal of Clinical Medicine .2019

13. 2018 Hsiao-Yun Chen,Liang-Ting Lin,Mong-Lien Wang,Kun-Ling Tsai,Pin-I Huang,Yi-Ping Yang, Yi-Yen Lee, Yi-Wei Chen, Wen-Liang Lo, Yuan-Tzu Lan, Shih-Hwa Chiou, Chien-Min Lin*, Hsin-I Ma, Ming-Teh Chen. . Musashi-1 promotes chemoresistant granule formation by PKR/eIF2α signalling cascade in refractory glioblastoma. . BBA - Molecular Basis of Disease. .2018

14. 2018 Navneet Kumar Dubey,Bou Yue Peng,Chien Min Lin,Peter D. Wang,Joseph R. Wang,,Chun Hao Chan, Hong Jian Wei, Win Ping Deng. . NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and the ERK1/2 pathway. . Int J Mol Sci. .2018

15. 2018 Heng-Wei Liu,Yu-Kai Su,Oluwaseun Adebayo Bamodu,Dueng-Yuan Hueng,Wei-Hwa Lee,Chun-Chih Huang, Li Deng, Michael Hsiao, Ming-Hsien Chien, Chi-Tai Yeh and Chien-Min Lin*. The Disruption of the - Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo. . Cancers. .2018

16. 2018 Chien‑Min Lin,, Hidetaka Arishima, ,Ken‑ichiro Kikuta, ,Hironobu Naiki, ,Ryuhei Kitai, ,Toshiaki Kodera, Ken Matsuda, Norichika Hashimoto, Makoto Isozaki, Kenzo Tsunetoshi, Hiroyuki Neishi, Yoshifumi Higashino, Ayumi Akazawa, Hiroshi Arai, Shinsuke Yamada. . Pathological examination of cerebral amyloid angiopathy in patients who underwent removal of lobar hemorrhages. . Journal of Neurology .2018 ;(0):1-11

17. 2017 Su YK, ,Shih PH, ,Lee WH, ,Bamodu OA, ,Wu ATH, ,Huang CC, Tzeng YM, Hsiao M, Yeh CT, Lin CM*. Antrodia cinnamomea sensitizes radio-/chemotherapy of cancer stem-like cells by modulating microRNA expression. . J Ethnopharmacol. .2017 ;(1):1-12

18. 2016 Chien-Min Lin,Yi-Tzu; Lin,Rong-Dih; Huang,Wei-Jan; Lee,Mei-Hsien. Neurocytoprotective Effects of Aliphatic Hydroxamates from Lovastatin, a Secondary Metabolite from Monascus-Fermented Red Mold Rice, in 6-Hydroxydopamine (6-OHDA)-Treated Nerve Growth Factor (NGF)-Differentiated PC12 Cell. . ACS Chemical Neuroscience .2016 ;(1):716-724

19. 2016 Chen WH,Lin CM,Huang CF,Hsu WC,Lee CH,Ou KL, Dubey NK, Deng WP.. Functional Recovery in Osteoarthritic Chondrocytes Through Hyaluronic Acid and Platelet-Rich Plasma-Inhibited Infrapatellar Fat Pad Adipocytes. . Am J Sports Med .2016 ;(1):1-12

20. 2016 Yen-Hao Su,Wen-Chien Huang,Tse-Hung Huang,Yan-Jiun Huang,Yu-Kai Sue,Thanh-Tuan Huynh, Michael Hsiao, Tsan-Zon Liu, Alexander TH Wu, Chien-Min Lin. Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes. . Oncotarget .2016 ;(0):0-0

21. 2015 Chien-Min Lin,Chi-Cheng Huang,Yan-Jiun Huang,Li Wei,Lei-Li Ting,Chia-Chun Kuo, Cheyu Hsu, Chiou JF, Alexander TH WU and Wei-Hwa Lee. Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. . Biotechnology and Applied Biochemistry .2015 ;(0):0-0

22. 2015 Chien-Min Lin,Jo-Ting Tsai,Chen Kuei Chang,Juei-Tang Cheng,Jia-Wei Lin. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats . Drug Design, Development and Therapy .2015 ;(9):4709-4717

23. 2015 Wei-Lun Lo,Yi-Shian Yeh,Yuan-Yun Tseng,Shun-Tai Yang,Jai-Wei Lin,Chien-Min Lin. Comparing Miniopen and Minimally Invasive Transforaminal Interbody Fusion in Single-Level Lumbar Degeneration. . BioMed Research International .2015 ;(2015):1-5

24. 2015 Kuo YT,Liu YL,Adebayo BO,Shih PH,Lee WH,Wang LS, Liao YF, Hsu WM, Yeh CT, Lin CM. JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma Cells . PLoS One .2015 ;(10(5))

25. 2015 Chien-Min Lin,Yi-Tzu; Lin,Rong-Dih; Huang,Wei-Jan; Lee,Mei-Hsien. Neurocytoprotective Effects of Aliphatic Hydroxamates from Lovastatin, a Secondary Metabolite from Monascus-Fermented Red Mold Rice, in 6-Hydroxydopamine (6-OHDA)-Treated Nerve Growth Factor (NGF)-Differentiated PC12 Cell. . ACS Chemical .2015

26. 2015 Su Y,Ishii Y,Lin CM,Tahara S,Teramoto A,Morita A. Endoscopic transsphenoidal cisternostomy for nonneoplastic sellar cysts . Biomed Res Int .2015 ;(389474)

27. 2015 Huynh TT,Lin CM,Lee WH,Wu AT,Lin YF,Yeh CT,Wang LS. Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating GRP78/miR-205 axis . J Nutr Biochem .2015 ;((5)):466-475

28. 2015 Lo WL,Lin CM,Yeh YS,Su YK,Tseng YY,Yang ST, Lin JW. Comparing miniopen and minimally invasive transforaminal interbody fusion in single-level lumbar degeneration . Biomed Res Int. .2015 ;(168384)

29. 2015 Chien-Min Lin,Ming-Chin Lin,Sheng Jean Huang,Cheng-Kuei Chang,Dan-Ping Chao,Tai-Ngar Lui, Hsin-I Ma, Ming-Ying Lin. A Prospective Randomized Study of Brain Tissue Oxygen Pressure-Guided Management in Moderate and Severe Traumatic Brain Injury Patients. . BioMed Research International .2015 ;(2015):1-8

30. 2015 Chien-Min Lin,Cheng-Kuei Chang,Mao-Tsun Lin,Yu-Chih Hsu,Ching-Ping Chang,Jia-Wei Lin. Protecting Against Ischemic Stroke in Rats by Heat Shock Protein 20-Mediated Exercise Preconditioning. . European Journal of Clinical Investigation .2015 ;(0):0-0

31. 2014 Lin JW,Shih CM,Chen YC,Lin CM,Tsai JT,Chiang YH, Shih R, Chiu PL, Hung KS, Yeh YS, Wei L, Chiu WT, Yang LY.. Biochemical alteration in cerebrospinal fluid precedes behavioral deficits in Parkinsonian rats induced by 6-hydroxydopamine . Surg Neurol. .2014 ;(Suppl):S55-65

32. 2013 Jo-Ting Tsai,Jia-Wei Lin,Chien-Min Lin,Yuan-Hao Chen,Hsin-I Ma,Yee-Min Jen, Yi-Hsun Chen, and Da-Tong Ju. Clinical Evaluation of CyberKnife in the Treatment of Vestibular Schwannomas . BioMed Research International 2013 .2013

33. 2010 Lin CM,Lin RD,Chen ST,Lin YP,Chiu WT,Lin JW, Hsu FL, Lee MH.. Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells. . Phytochemistry. .2010 ;(71):2147-2156

34. 2010 Tai PA,Chang CK,Niu KC,Lin MT,Lin CM. Attenuating of Experimental Spinal Cord Injury by Hyperbaric Oxygen:Stimulating Production of Vasculoendothelial and Glial Cell Lines Derived Neurotrophic Growth Factors and Interleukin-10.J Neurotrauma. . Neurotrauma .2010 ;(27):1121-1127

35. 2009 Lin CM,Lin JW,Wei L,Yeh YS,Chiang YH,Hung KS, Yang LY, Chiu WT.. Hyaluronic acid inhibits the glial scar formation after brain damage with tissue loss in rats. . Surg Neurol .2009 ;(72):S2:50-S2:54

36. 2009 Liao KH,Chang CK,Chang HC,Chang KC,Chen CF,Chen TY, Chou CW, Chung WY, Chiang YH, Hong KS, Hsiao SH, Hsu YH, Huang HL, Huang SC, Hung CC, Kung. Clinical practice guidelines in severe traumatic brain injury in Taiwan . Surg Neurol .2009

37. 2009 Lin JW,Shih CM,Chen YC,Lin CM,Tsai JT,Chiang YH, Hung KS, Yeh YS, Wei L, Chiu WT, Yang LY.. Biochemical Alteration in CSF Precedes Behavioral Deficits in Parkinsonian Rats Induced by 6-OHDA. . Surg Neurol .2009 ;(72):55-65

38. 2008 Lin JW,Tsai JT,Lin CM,Lee LM,Hung KS,Huang SJ, Hsiao SH, Chung WY, Tsai MD, Hsia CC, Hung CC, Chiu WT.. Evaluation of optimal cerebral perfusion pressure in severe traumatic brain injury. . Acta Neurochir Suppl .2008 ;(101):131-136

39. 2008 Lin JW,Tsai JT,Lin CM,Hung KS,Hung CC,Chiu WT. Neurotrauma research in Taiwan. . Acta Neurochir Suppl .2008 ;(101):113-117

40. 2008 Lin CM,Lin JW,Tsai JT,Ko CP,Hung KS,Hung CC, Su YK, Wei L, Chiu WT, Lee LM.. Intracranial pressure fluctuation during hemodialysis in renal failure patients with intracranial hemorrhage. . Acta Neurochir Suppl .2008 ;(101):141-144

研究計畫

計畫名稱
113 聯合靶向Btk/PD-L1/PD-L2腫瘤免疫訊號軸作為治療抗藥性膠質母細胞瘤之治療功效及臨床前評估(3/3)
補助單位
國家科學及技術委員會

計畫名稱
112 聯合靶向Btk/PD-L1/PD-L2腫瘤免疫訊號軸作為治療抗藥性膠質母細胞瘤之治療功效及臨床前評估(2/3)
補助單位
國家科學及技術委員會

計畫名稱
111 聯合靶向Btk/PD-L1/PD-L2腫瘤免疫訊號軸作為治療抗藥性膠質母細胞瘤之治療功效及臨床前評估(1/3)
補助單位
國家科學及技術委員會

計畫名稱
110 探討膠質母細胞瘤外泌體中Btk/PD-L1/PD-L2 訊號途徑在腫瘤免疫所扮演的致病角色及其精準治療應用
補助單位
科技部

計畫名稱
109 探討以Myc/PD-L1/Akt作為治療惡性腦癌標靶之轉譯研究(3/3)
補助單位
科技部

計畫名稱
108 探討以Myc/PD-L1/Akt作為治療惡性腦癌標靶之轉譯研究(2/3)
補助單位
科技部

計畫名稱
107 探討以Myc/PD-L1/Akt作為治療惡性腦癌標靶之轉譯研究(1/3)
補助單位
科技部