黃偉展(Huang, Wei-Jan)　教授

Email
wjhuang@tmu.edu.tw
現   職
藥物科學學科 教授
藥學院 副院長

學經歷

學　歷

畢業學校與學位[修業時間]
國立臺灣大學藥學研究所 博士
1996/09~2002/06
國立臺灣大學藥學研究所 碩士
1992/09~1995/01
台北醫學大學藥學系 學士
1988/09~1992/06

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科教授
2022/03/15~
生藥學研究所教授
2017/08/01~2022/03/14
生藥學研究所副教授
2011/08/01~2017/07/31
生藥學研究所助理教授
2007/08/16~2011/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
藥學院副院長
2024/01/01 ~
生藥學研究所教授
2022/03/15 ~
藥物科學學科教授
2019/11/01 ~ 2022/03/14
藥物科學學科主任
2019/08/01 ~ 2023/12/31
中草藥臨床藥物研發博士學位學程
2013/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
長庚技術學院助理教授
2004/08~2007/08
清華大學博士後研究
2003/09~2004/07
台灣大學醫學院博士後研究
2002/07~2003/08

專長與研究領域

學門領域
天然物化學
藥物化學
有機化學
學術專長
有機合成
酵素活性

論文著作

清冊下載

論文 Journal Paper


1. 2024 A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress . Biomedicine & Pharmacotherapy .2024 ;(174):116538-116538.

2. 2023 Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors . Biomedicine & Pharmacotherapy .2023 ;(159):114258-114258

3. 2023 Hsu Jui Yi,Hsu Kai Cheng,Sun Ching,Chou Ching Hsuan,Lin Tony Eight,Sung Tzu Ying,Tseng Hui Ju,Yen Shih Chung,Yang Chia Ron,Huang Wei Jan,Hsu Jui Yi,Hsu Kai Cheng,Sun Ching,Chou Ching Hsuan,Lin Tony Eight,Sung Tzu Ying,Tseng Hui Ju,Yen Shih Chung,Yang Chia Ron,Huang Wei Jan. Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors . Biomedicine and Pharmacotherapy .2023 ;(159)

4. 2023 Tseng HJ,Chen WC,Kuo TF,Yang G,Feng CS,Chen HM, Chen TY, Lee TH, Yang WC, Tsai KC, Huang WJ.. Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice . Cell Mol Life Sci .2023 ;(80):101-101

5. 2023 Chu JC ,Tseng HJ ,Lee SB ,Hsu KC ,Hsin LW ,Liang RH, Lin TE , Gao NC, Chen LC, Lu WH, Wang AHJ, Huang WJ. Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities . Journal of Enzyme Inhibition and Medicinal Chemistry .2023

6. 2021 Hsu KC,Chu JC,Tseng HJ,Liu CI,Wang HC,Lin TE,Lee HS,Hsin LW,Wang AHJ,Lin CH,Huang WJ. Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors . European Journal of Medicinal Chemistry .2021 ;(219):113419-113419

7. 2021 Hsu JY,Sathyan AR,Hsu KC,Chen LC,Yen CC,Tseng HJ, Wu KC, Liu HK, Huang WJ. Synthesis of yakuchinone b-inspired inhibitors against islet amyloid polypeptide aggregation . Journal of Natural Products .2021 ;(84):1096-1103

8. 2021 Yen SC,Chen LC,Huang HL,Ngo ST,Wu YW,Lin TE, Sung TY, Lien ST, Tseng HJ, Pan SL, Huang WJ, Hsu KC. Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia . Journal of Natural Products .2021 ;(84):1-10

9. 2020 Leu WJ ,Chu JC,Hsu JL ,Du CM,Jiang YH ,Hsu LC, Huang WJ, Guh JH . Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies . Molecules .2020 ;(25):5960-5960

10. 2020 Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease . European Journal of Medicinal Chemistry .2020 ;(192):112193

11. 2020 Acetylcholinesterase inhibitory activity and neuroprotection in vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice . Food Function .2020 ;(11):2328-2338

12. 2020 Tseng Hui Ju,Lin Mei Hsiang,Shiao Young Ji,Yang Ying Chen,Chu Jung Chun,Chen Chun Yung,Chen Yi Ying,Lin Tony Eight,Su Chih Jou,Pan Shiow Lin,Chen Liang Chieh,Wang Chen Yu,Hsu Kai Cheng,Huang Wei Jan,Tseng Hui Ju,Lin Mei Hsiang,Shiao Young Ji,Yang Ying Chen,Chu Jung Chun,Chen Chun Yung,Chen Yi Ying,Lin Tony Eight,Su Chih Jou,Pan Shiow Lin,Chen Liang Chieh,Wang Chen Yu,Hsu Kai Cheng,Huang Wei Jan. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease . European Journal of Medicinal Chemistry .2020 ;(192):112193-112193

13. 2019 Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor. . Biomolecules .2019

14. 2018 Chen LC ,Tseng HJ ,Liu C Y ,Huang Y Y ,Yen CC ,Weng JR , Lu YL , Hou WC, Lin TE, Pan IH, Huang KK, Huang WJ. Hsu KC . Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation . Frontiers in Pharmacology .2018 ;(9):708-708

15. 2018 Chao SW ,Chen LC ,Yu CC,Liu CY ,Lin TE ,Guh JH, Wang CY , Chen CY , Hsu KC , Huang WJ . Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activitie . European Journal of Medicinal Chemistry .2018 ;(143):792-805

16. 2018 Yen CS,Choy CS ,Huang WJ ,Huang SW ,Lai PY , Yu MC, Shiue C, Hsu YF, Hsu MJ. A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade . Frontiers in Pharmacology .2018 ;(9)

17. 2017 Chuang YF,Huang SW,Hsu YF,Yu MC,Ou G,Huang WJ, Hsu MJ. WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via the SHP-1-STAT3-survivin cascade . British Journal of Pharmacology .2017 ;(174):2941-2961

18. 2017 Hsu KC,Liu CY,Lin TE,Hsieh JH,Sung TY,Tseng HJ, Yang JM, Huang WJ. Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach . Scientific Reports .2017 ;(0):0-0

19. 2017 Chen LC ,Hsu KC ,Chiou LC ,Tseng HJ ,Huang WJ. Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative . Molecules .2017 ;(22):1897

20. 2017 Jan JS ,Chou YC ,Cheng YW ,Chen CK ,Huang WJ,Hsiao G . The novel HDAC8 inhibitor WK2-16 attenuates lipopolysaccharide-activated matrix metalloproteinase-9 expression in human monocytic cells and improves hypercytokinemia in vivo . International Journal of Molecular Sciences .2017 ;(18):E1394-E1394

21. 2017 Wu YH ,Hong CW,Wang YC ,Huang WJ,Yeh YL ,Wang BJ , Wang YJ , Chiu HW . A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer . Cancer Letters .2017 ;(400):79-88

22. 2017 Shieh JM ,Tang Y A ,Hu FH ,Huang WJ ,Wang YJ ,Jayu J, Liao SY, Lu YH, Yeh YL, Wang TW, Lin P, Wang YC . A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer . International Journal of Cancer .2017 ;(140):2375-2386

23. 2016 Huang YH,Huang SW,Hsu YF,Ou G,Huang WJ,Hsu MJ. The effects of a novel aliphatic-chain hydroxamate derivativeWMJ-S-001 in HCT116 colorectal cancer cell death . .2016 ;(5):15900-15900

24. 2016 Lin RK,Lin YF,Hsu MJ,Hsieh CL,Wang CY,Huang CC, Huang WJ. Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species hydroxamates that induce reactive oxygen species . Bioorganic Medicinal Chemistry Letters .2016 ;(26):5528-5533

25. 2015 ChenWC,Yen CS,Huang WJ,Hsu YF,Ou G ,,Hsu MJ. WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in LPS-stimulated RAW264.7 macrophages . Br J Pharmacol .2015 ;(172):1894-1908

26. 2015 Huang YH,Huang SW,Hsu YF,Ou G,Huang WJ,Hsu MJ. The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death . Scientific Reports .2015 ;(5):15900-15900

27. 2015 Huang WJ,LeeHJ,Chen HL,Fan PC,Ku YL,Chiou LC. Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice . Journal ofEthnopharmacology .2015 ;(166):18-22

28. 2015 Lin CM,Lin YT,Lin RD,Huang WJ,LeeMH. Neurocytoprotective Effects of Aliphatic Hydroxamates from Lovastatin, a Secondary Metabolite from Monascus-Fermented Red Mold Rice, in 6‑Hydroxydopamine (6-OHDA)-Treated Nerve Growth Factor (NGF)-Differentiated PC12 Cells . ACS Chemical Neuroscience .2015

29. 2015 Chao SW,Su MY,LC Chiou,LC Chen,CI Chang,WJ Huang. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim‑1 . Journal of Natural Products .2015 ;(78):1969-1976

30. 2015 Lin CM,Lin YT,Lin RD,Huang WJ,Lee MH. Neurocytoprotective Effects of Aliphatic Hydroxamates from Lovastatin, a Secondary Metabolite from Monascus-Fermented Red Mold Rice, in 6‑Hydroxydopamine (6-OHDA)-Treated Nerve Growth Factor (NGF)-Differentiated PC12 Cells . ACS Chem. Neurosci .2015 ;(6):716-724

31. 2014 Pan KL,Huang WJ,Hsu MH,Lee HL,Liu HJ,Cheng CW , Tsai MH , Shen MY, Lin P. Identification of trans,trans-2,4-Decadienal Metabolites in Mouse and Human Cells Using Liquid Chromatography−Mass Spectrometry . Chem Res Toxicol .2014 ;(27):1707-1719

32. 2014 Suk FM,Lien GS,Huang WJ,Chen CN,Lu SY,Yang YC, Yan MD, Liang YC. A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in Human Hepatoma Cells . Evid Based Complement Alternat Med .2014 ;(2013):658370

33. 2014 Huang WJ,Tang YA,Chen MY,Wang YJ,Hu FH,Wang TW, Chao SW, Chiu HW, Yeh YL, Chang HY, Juan HF, Lin P, Wang YC. A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies. . Cancer Lett .2014 ;(346):84-93

34. 2014 Lin TY,Huang WJ,Wu CC,Lu CW,Wang SJ. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats. . PLoS One .2014 ;(10):e88644

35. 2014 Liu LY,Huang WJ,Ho FM,Lin RJ,Lin SY,Suk FM, Liang YC. N-Hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells. . Chem Biol Interact .2014 ;(217):1-8

36. 2014 Yu CC,Pan SL,Chao SW,Liu SP,Hsu JL,Yang YC, Li TK, Huang WJ, Guh JH.. A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I. . Biochem Pharmacol .2014 ;(90):320-330

37. 2014 Chen YC,Huang WJ,Hsu JL,Yu CC,Wang WT,Guh JH. A Novel Hydroxysuberamide Derivative Potentiates MG132-Mediated Anticancer Activity Against Human Hormone Refractory Prostate Cancers TheRoleof Histone Deacetylase and Endoplasmic Reticulum Stress . Prostate .2014 ;(73):1270-1280

38. 2013 Liu LY,Huang WJ,Lin RJ,Lin SY,Liang YC. N-Hydroxycinnamide Derivatives of Osthole Presenting Genotoxicity and Cytotoxicity against Human Colon Adenocarcinoma Cells in Vitro and in Vivo. . Chem. Res. Toxicol .2013 ;(26):1683-1691

39. 2013 Chiu HW,Yeh YL,Wang YC,Huang WJ,Chen YA,Chiou YS, Ho SY,Lin P, Wang YJ. Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo . PLoS One .2013 ;(10):e76340

40. 2013 Chiu HW,Yeh YL,Wang YC,Huang WJ,Chen YA,Chiou YS, Ho SY,Lin P, Wang YJ. Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo . PLoS One .2013 ;(10):e76340

41. 2012 Huang WJ,Liang YC,Chuang SE,Chi LL,Lee CY,Lin CW, Chen AL, Huang JS, Chiu CJ, Lee CF, Huang CY,Chen CN. NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity . Evidence-Based Complementary and Alternative Medicine .2012

42. 2012 Chen HL,Lee HJ,Huang WJ,Chou JF,Fan PC,Du JC, Ku YL, Chiou LC. Clerodendrum inerme Leaf Extract Alleviates Animal Behaviors, Hyperlocomotion, and Prepulse Inhibition Disruptions,Mimicking Tourette Syndrome and Schizophrenia . Evidence-Based Complementary and Alternative Medicine .2012 ;(2012):284301-284308

43. 2012 Huang WJ,Wang YC,Chao SW,Yang CY,Chen LC,Lin MH, Hou WC, Chen MY, Lee TL, Yang P, Chang CI. Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors . ChemMedChem .2012 ;(7):1815-1824

44. 2012 Huang CY,Chi LL,Huang WJ,Chen YW,Chen WJ,Kuo YC, Cheng MY, Chen CN. Growth Stimulating Effect on Queen Bee Larvae of Histone Deacetylase Inhibitors . Journal of Agriculture and Food Chemistry .2012 ;(60):6139-6149

45. 2012 Lin TY,Lu CW,Huang WJ,Wang SJ. Involvement of the cGMP Pathway in the Osthole-Facilitated Glutamate Release in Rat Hippocampal Nerve Endings . SYNAPSE .2012 ;(66):232-239

46. 2011 Lin MH & Liu HK,Huang WJ,Huang CC,Wu TH,HSu FL. Evaluation of the potential hypoglycemic and Beta-cell protective constituents isolated from Corni fructus to tackle insulin-dependent diabetes mellitus. . J Agric Food Chem .2011 ;(59):7743-7751

47. 2011 Chia-Nan Chen,Che-Jen Hsiao,Shoei-Sheng Lee,Jih-Hwa Guh,Po-Cheng Chiang,Chih-Chiang Huang, Wei-Jan Huang*. Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis. . Natural Product Research .2011

48. 2011 Ting-Chun Kuo,Wei-Jan Huang,Jih-Hwa Guh. A methoxyflavanone derivative displays anticancer activity through protein kinase C-α related crosstalk of mitochondrial and endoplasmic reticulum stresses in human hormone-refractory prostate cancer cells. . Acta Pharmacologica Sinica .2011 ;(32):89-98

49. 2011 Yuh-Hwa Liu,Wei-Jan Huang,Yeh-Lin LU,Chi-Ching Lee,Yow-Fu Tsai,Wen-Chun Wu, Wen-Chi Hou. Semicarbazide-sensitive amine oxidase inhibitory activity of galacturonic acid hydroxamate . Botanical Studies .2011 ;(52):35-40

50. 2011 Wei-Jan Huang,Ching-Chow Chen,Shi-Wei Chao,Chia-Chun Yu,Chen-Yui Yang,Jih-Hwa Guh, Yun-Chieh Lin, Chiao-I Kuo, Ping Yang , Chung-I Chang. Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors . European Journal of Medicinal Chemistry .2011 ;(46):4042-4049

51. 2011 Huang WJ,Liang YC,Chuang SE,Chi LL,Lee CY,Lin CW, Chen AL, Huang JS, Chiu CJ, Lee CF, Huang CY, Chen CN. NBM-HD-1: a novel histone deacetylase inhibitor with anticancer activity . eCAM .2011

52. 2011 Huang WJ,Liang YC,Chuang SE,Chi LL,Lee CY,Lin CW, Chen AL, Huang JS, Chiu CJ, Lee CF, Huang CY, Chen CN. NBM-HD-1: a novel histone deacetylase inhibitor with anticancer activity . eCAM .2011 ;(2012):781417-781426

53. 2011 Wei-Jan Huang,Chia-Wei Lin,Chi-Yun Lee,Li-Ling Chi,Yi-Chen Chao,Hsien-Ning Wang,Bi-Lian Chiou, Tzu-Jung Chen, Chung-Yang Huang, Chia-Nan Chen. NBM-HD-3, a novel histone deacetylase inhibitor with anticancer activity through modulation of PTEN and AKT in brain cancer cells . Journal of Ethnopharmacology .2011 ;(136):156-167

54. 2010 Chia-Nan Chen,Che-Jen Hsiao,Shoei-Sheng Lee,Jih-Hwa Guh,Po-Cheng Chiang,Chih-Chiang Huang, Wei-Jan Huang*. Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis. . Natural Product Research .2010 ;(-):---

55. 2010 Lin TY,Lu CW,Huang WJ,Wang SJ. Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings . Synapse .2010 ;(64):390-396

56. 2010 Wei-Jan Huang,Ching-Chow Chen,Shi-Wei Chao,Shoei-Sheng Lee,Fen-Lin Hsu,Yeh-Lin Lu, Ming-Fang Hung, Chung-I Chang. Synthesis of N-Hydroxycinnamides Capped with a Naturally Occurring Moiety as Inhibitors of Histone Deacetylase . ChemMedChem .2010 ;(5):598-607

57. 2010 Wei-Jan Huang,Chia-Li Wu,Chia-Wei Lin,Li-Ling Chi,Pen-Yuan Chen,Chun-Jung Chiu, Chung-Yang Huang, Chia-Nan Chen. Marchantin A, a cyclic bis(bibenzyl ether), isolated from the liverwort Marchantia emarginata subsp. tosana induces apoptosis in human MCF-7 breast cancer cells . Cancer letters .2010 ;(291):108-119

58. 2010 Wei-Jan Huang,Ho-Shan Niu,Mei-Hsiang Lin,Juei-Tang Cheng,Fen-Lin Hsu. Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats. . Journal of Natural Products .2010 ;(73):1170-1172

59. 2010 Wei-Jan Huang,Chih-Chiang Huang,Ling-Wei Hsin,Yeun-Min Tsai,Chin-Ting Lin,Jung-Hsin Lin, Shoei-Sheng Lee*. Improved enamine-type addition of dehydroaporphine using microwave irradiation . tetrahedron letters .2010 ;(51):3062-3064

60. 2010 Yu-Wei Sun,Wei-Jan Huang,Che-Jen Hsiao,Yi-Cheng Chen,Pin-Hsuan Lu,Jih-Hwa Guh. Methoxychalcone InducesCell-CycleArrest and Apoptosis in HumanHormone-Resistant Prostate CancerCellsThrough PI 3-Kinase-Independent Inhibition of mTOR Pathways. . The Prostate .2010 ;(70):1295-1306

61. 2010 Li-Ching Lin,Feng-Ming Ho,Shish-Jung Yen,Pei-Yi Wu,Ling-Fang Hung,Wei-Jan Huang*,Yu-Chih Liang*. Carbon monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes. . International Immunopharmacology .2010 ;(10):1520-1525

62. 2010 Huang WJ,Niu HS,Lin MH,Cheng JT,Hsu FL. Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats . Journal of Natural Products .2010 ;(73):1170-1172

63. 2010 Huang WJ,Niu HS,Lin MH,Cheng JT,Hsu FL. Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats . Journal of Natural Products .2010 ;(73):1170-1172

64. 2009 Huang WJ,Wu CL,Lin CW,Chi LL,Chen PY,Chiu CJ, Huang CY, Chen CN. Marchantin A, a cyclic bis(bibenzyl ether), isolated from the liverwort Marchantia emarginata subsp. tosana induces apoptosis in human MCF-7 breast cancer cells . Cancer Letters .2009

65. 2009 Fan PC,Huang WJ,Chiou LC. Intractable Chronic Motor Tics Dramatically Respond to Clerodendrum inerme (L) Gaertn. . JOURNAL OF CHILD NEUROLOGY .2009 ;(24):887-890

66. 2008 Wang SJ,Lin TY,Lu CW,Huang WJ. Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals . NEUROCHEMISTRY INTERNATIONAL .2008 ;(53):416-423

67. 2008 Chang Y,Huang WJ,Tien LT,Wang SJ. Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes) . EUROPEAN JOURNAL OF PHARMACOLOGY .2008 ;(578):28-36

68. 2008 Huang CH,Huang WJ,Wang SJ,Wu PH,Wu WB. Litebamine, a phenanthrene alkaloid from the wood of Litsea cubeba, inhibits rat smooth muscle cell adhesion and migration on collagen . European Journal of Pharmacology .2008 ;(596):25-31

69. 2008 Chang CC,Liu DZ,Lin SY,Liang HJ,Hou WC,Huang WJ, Chang CH, Ho FM, Liang YC. Liposome encapsulation reduces cantharidin toxicity . Food and Chemical Toxicology .2008 ;(46):3116-3121

70. 2008 Lin CL,Ho C,Tung CW,Huang WJ,Chang PJ,Yang JT , Wang JY. Simvastatin Reverses High Glucose-Induced Apoptosis of Mesangial Cells via Modulation of Wnt Signaling Pathway . American Journal of Nephrology .2008 ;(28):290-297

71. 2007 Singh OV,Huang WJ,Chen CH,Lee SS. Manganese(III) acetate mediated oxidation of aporphines: a convenient and useful synthesis of oxoaporphines . Tetrahedron Letters .2007 ;(48):8166-8169

72. 2007 Lin CL,Lin SJ,Huang WJ,Ku YL,Tsai TH,Hsu FL. Novel ent-beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina . Planta Medica .2007 ;(73):1581-1587

73. 2007 Huang WJ,Huang CH,Wu CL,Lin JK,Chen YW,Lin CL, Huang CY, Chen CN. Propolin G, a prenylflavanone, isolated from Taiwanese propolis, induces caspase-dependent apoptosis in brain cancer cells . J. Agri Food Chem .2007 ;(55):7366-7376

74. 2007 Chou CW,Huang WJ,Tien LT,Wang SJ. . (-)-Epigallocatechin Gallate, the most active polyphenolic catechin in green tea, presynaptically facilitates Ca2+-dependent glutamate release via activation of protein kinase C in rat cerebral cortex: . Synapse .2007 ;(61):889-902

75. 2007 Huang WJ,Tung CW,Ho C,Yang JT,Huang CF,Chang PJ, Hsu YC, Lee PH, Lin CL. Ras activation modulates methylglyoxal-induced mesangial cell apoptosis through superoxide production . Renal Failure .2007 ;(29):911-921

76. 2007 Ho C,Lee PH,Huang WJ,Hsu YC,Lin CL,Wang JY. Methylglyoxal-induced Fibronectin gene . Methylglyoxal-induced Fibronectin gene expression through Ras-mediated NADPH oxidase activation in renal mesangial cells . Nephrology .2007 ;(12):348-356

77. 2006 Mahindro N,Wang CC,Liao CC,Huang CF,Lu IL,Lien TW, Peng YH, Huang WJ, Lin YT. Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies . J. Med. Chem .2006 ;(49):1212-1216

78. 2005 Lee SL,Huang WJ,Lin WW,Lee SS,Chen CH. , Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs . Bioorg. Med. Chem .2005 ;(13):6175-6181

79. 2005 Mahindro N,Huang CF,Peng YH,Wang CC,Lien TW,Liao CC, Kumar S, Huang WJ, Chen CP, Hsu TA, Praka. Novel Indole–based PPAR Agonists: Design, SAR, Structural Biology and Biological Activities . J. Med. Chem .2005 ;(48):8194-8208

80. 2004 Huang WJ,Singh OV,Chen CH,Lee SS. Synthesis of (+)-Glaucine and (+)-Neospirodienone via an one-pot Bischler-Napieralski Reaction and Oxidative Coupling by a Hypervalent Iodine Reagent . Helv Chim Acta .2004 ;(87):167-174

81. 2003 Huang WJ,Chen C H,Lee SS. Preparation of 6-Phenyl- and 8-Phenyl- Tetrahydroisoquinolines from Boldine . Heterocycles .2003 ;(60):1573-1588

82. 2002 Huang WJ,Singh OV,Chen CH,Lee SS. Activation of Iodosobenzene by Catalytic Tetrabutylammonium Iodide and Its Application in the Oxidation of some Isoquinoline Alkaloids . Helv Chim Acta .2002 ;(85):1069-1078

83. 2002 Huang WJ,Chen CH,Singh OV,Lee SL,Lee SS. A Facile Method for the Synthesis of Glaucine and Norglaucine from Boldine . Synth. Commun .2002 ;(32):3681-3686

研究計畫

計畫名稱
113 設計與合成新穎週期蛋白依賴性激酶8（CDK8）抑制劑作為具治療特發性肺纖維化潛力先導化合物(1/3)
補助單位
國家科學及技術委員會
計畫名稱
112 探索新穎可逆性蛋白質雙硫鍵異構酶抑 制劑
補助單位
國家科學及技術委員會
計畫名稱
112 結構優化苯丙炔醯胺基礎之蛋白質雙硫鍵異構酶抑制劑以作為具潛力之抗多形性神經膠質母細胞瘤試劑(3/3)
補助單位
國家科學及技術委員會
計畫名稱
112 貴機構依本會「補助國內研究生出席國際學術會議」申請費 用補助案(研究生：生藥學研究所碩士班高念楚君)
補助單位
國家科學及技術委員會
計畫名稱
111 結構優化苯丙炔醯胺基礎之蛋白質雙硫鍵異構酶抑制劑以作為具潛力之抗多形性神經膠質母細胞瘤試劑(2/3)
補助單位
國家科學及技術委員會
計畫名稱
110 合成小分子1008與2003
補助單位
財團法人工業技術研究院
計畫名稱
110 結構優化苯丙炔醯胺基礎之蛋白質雙硫鍵異構酶抑制劑以作為具潛力之抗多形性神經膠質母細胞瘤試劑(1/3)
補助單位
科技部
計畫名稱
109 開發蛋白質雙硫鍵異構酶抑制劑作為抗多形性神經膠質母細胞瘤藥物
補助單位
科技部
計畫名稱
108 新穎小分子抗多發性骨髓瘤藥物機轉研究
補助單位
科技部
計畫名稱
108 ENERGI應用於改善第二型糖尿病之活性研究計畫
補助單位
華安醫學股份有限公司
計畫名稱
108 SK2-b1之量化和成
補助單位
財團法人工業技術研究院
計畫名稱
108 製備1g SK2-b1
補助單位
財團法人工業技術研究院
計畫名稱
108 開發多標靶抗阿茲海默症藥物
補助單位
科技部
計畫名稱
108 貴校生藥學研究所碩士班研究生彭浩源君擬於109年3月25日至3月28日赴日本京都參加日本藥學會第140年會，依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案，核定補助如說明，請查照。
補助單位
科技部
計畫名稱
107 新穎雜環苯醯胺類化合物之開發研究
補助單位
華上生技醫藥股份有限公司
計畫名稱
107 以acridine為scaffold透過雙標靶策略發展新穎抗癌藥物(3/3)
補助單位
科技部
計畫名稱
107 貴校生藥學研究所碩士班研究生朱鎔駿君擬於108年3月20日至3月23日赴日本千葉縣參加日本藥學會第139屆年會，依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案，核定補助如說明，請查照
補助單位
計畫名稱
106 合成psoralen與trans-sobrerol衍生物研究計畫
補助單位
財團法人工業技術研究院
計畫名稱
106 新穎萘醯胺類化合物之開發研究計畫
補助單位
華上生技醫藥股份有限公司
計畫名稱
106 以acridine為scaffold透過雙標靶策略發展新穎抗癌藥物(2/3)
補助單位
科技部
計畫名稱
105 以acridine為scaffold透過雙標靶策略發展新穎抗癌藥物(1/3)
補助單位
科技部
計畫名稱
105 以acridine為scaffold透過雙標靶策略發展新穎抗癌藥物(1/3)
補助單位
計畫名稱
105 研究生曾惠如君擬於106年4月2日至4月6日赴美國舊金山(San Francisco,California)參加第253屆美國化學學會年會
補助單位
科技部
計畫名稱
105 生藥學研究所碩士班研究生陳俊詠君擬於106年3月24日至3月27日赴日本宮城縣Miyagi-ken參加日本藥學會第137年會(仙台)
補助單位
科技部
計畫名稱
105 藥學系博士班研究生陳亮傑君106年4月2日至4月6日赴美國舊金山(San Francisco,California)參加第253屆美國化學年會，依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案
補助單位
科技部
計畫名稱
104 以HE-01RF1為先導化合物進行結構修飾
補助單位
財團法人工業技術研究院
計畫名稱
104 以具天然物結構之混成分子及鄰位聯苯取代之氮-羥基肉桂酸醯胺為先導化合物進行結構修飾以作為抗癌藥物(3/3)
補助單位
科技部
計畫名稱
104 以具天然物結構之混成分子及鄰位聯苯取代之氮-羥基肉桂酸醯胺為先導化合物進行結構修飾以作為抗癌藥物(3/3)
補助單位
科技部
計畫名稱
103 以具天然物結構之混成分子及鄰位聯苯取代之氮-羥基肉桂酸醯胺為先導化合物進行結構修飾以作為抗癌藥物(2/3)
補助單位
行政院國家科學委員會
計畫名稱
103 LED激發薄膜化D-乳酸感測器之研究
補助單位
臺北科技大學
計畫名稱
102 對組蛋白去乙醯酶第八型選擇性抑制劑TMUAS26294結構優勢化以作為抗癌藥物-曾惠如
補助單位
科技部
計畫名稱
102 以具天然物結構之混成分子及鄰位聯苯取代之氮-羥基肉桂酸醯胺為先導化合物進行結構修飾以作為抗癌藥物(1/3)
補助單位
行政院國家科學委員會
計畫名稱
102 以具天然物結構之混成分子及鄰位聯苯取代之氮-羥基肉桂酸醯胺為先導化合物進行結構修飾以作為抗癌藥物(1/3)
補助單位
科技部
計畫名稱
102 以具天然物結構之混成分子及鄰位聯苯取代之氮-羥基肉桂酸醯胺為先導化合物進行結構修飾以作為抗癌藥物(2/3)
補助單位
科技部
計畫名稱
102 開發以特殊雙硫雜環結合奈米金與DOXORUBICIN之新藥物劑型平台之建立-化學鍵結分子設計與合成
補助單位
華上生技醫藥股份有限公司
計畫名稱
101 利用天然物scaffold及knowledge-based design發展新穎標靶抗癌藥物
補助單位
行政院國家科學委員會
計畫名稱
100 以天然物為cap合成之醯基羥胺作為新型選擇性組蛋白去乙醯抑制劑
補助單位
行政院國家科學委員會
計畫名稱
99 從天然物開發新型HDAC抑制劑及其生物活性之研究
補助單位
行政院國家科學委員會
計畫名稱
98 從天然物開發新型HDAC抑制劑及其生物活性之研究
補助單位
行政院國家科學委員會
計畫名稱
96 活血化瘀藥薑黃及丹參抑制糖尿病腎纖維化之研究(2-2)
補助單位
行政院國家科學委員會
計畫名稱
96 從天然物開發新型HDAC抑制劑及其生物活性之研究
補助單位
行政院國家科學委員會
計畫名稱
96 從天然物開發新型HDAC抑制劑
補助單位
臺北醫學大學新聘教師計畫