TMU-教師人才庫

林美香(Lin, Mei-Hsiang)　副教授

Email
mhl00001@tmu.edu.tw

現職

藥物科學學科副教授

學經歷

學　歷

畢業學校與學位[修業時間]
國立臺灣大學藥理學研究所博士 1998/09/01~2003/06/30
國立臺灣大學醫學院藥研所碩士 1991/09/01~1993/06/01
臺北醫學大學藥學系學士 1990/09/01~1991/06/01

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科副教授 2012/08/01~
藥物科學學科助理教授 2012/02/01~2012/07/31
藥學系助理教授 2007/08/01~2012/01/31
生化學科助理教授 2004/02/01~2007/07/31
生化學科講師 1998/08/01~2004/01/31
生化學科助教 1995/03/01~1998/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
藥物科學學科主任 2016/08/01 ~ 2019/07/31
生化學科助理教授 2007/08/01 ~
醫學科學研究所助理教授 2007/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
臺灣大學助理 2003/09/01~1994/01/31
私立臺北醫學院附設醫院藥師 1994/02/01~1995/02/28

專長與研究領域

學門領域
藥物化學、有機合成
藥學

學術專長
有機化學實驗操作
IR. GC操作

論文著作

清冊下載

論文 Journal Paper

1.	2025 Chu MH,Liu TW,Chen PH ,Chen YH,Tang KL,Hsu SJ, Iskandar B, Yin HW, Lin MH, Lee CK. Investigation of the acetylcholinesterase inhibitors of Mentha genus essential oils with in vitro and in silico approaches . Industrial Crops & Products .2025 ;( 227):120783-120783

2025 Chu JC, ,Tsai KC, ,Wang TY, ,Chen TY, ,Tsai JY, ,Lee T, Lin MH, Hsieh YSY, Wu CC, Huang WJ*,. Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase, . European Journal of Medicinal Chemistry .2025 ;(283):117169-117169

3.	2025 Dai JZ,Hsu WJ,Lin MH,Shueng PW,Lee CC,Yang CC, Lin CW*. YAP-mediated DDX3X confers resistance to ferroptosis in breast cancer by reducing lipid peroxidation . Free Radical Biology and Medicine .2025 ;(232):330-339

4.	2024 ,林美香,, 林政緯. Melatonin increases Olaparib sensitivity and suppresses cancer-associated fibroblast infiltration via suppressing the LAMB3-CXCL2 axis in TNBC . Pharmacological Research .2024 ;(209):107429-107429

2023 Chiu PF ,Lin IC,Lu YL,Chang CN, Chan HY,Lin TS, Tsai KC, Hsieh YSY, Chen MJ, Lin MH*, Liang PH*. Design, structure–activity relationships, and enzyme kinetic studies of tricyclic and tetracyclic coumarin–based sulfamates as steroid sulfatase inhibitors . Bioorganic Chemistry .2023 ;(138):106581-106581

2022 Kan TC,Lin MH,Cheng CC ,Lu JW,Sheu MT,Ho YS, Sri Ra-hayu, and Chang JS. Preclinical therapeutic assessment of a new chemotherapeutics [dichloro(4,4'-bis(2,2,3,3-tetrafluoropropoxy)methyl)-2,2'-bi-pryridine) platinum] in an orthotopic patient-derived xenograft 4 model of triple negative breast cancers . Pharmaceutics .2022 ;(14):839-839

2022 Chang CN,Lin IC,Lin TS,Chiu PF,Lu YL,Manmath Narwane, Liu IC, Hng Y, Tsai KC, Lin MH, Hsieh YSY, Chen MJ, Liang PH . The Design, Structure–Activity, and kinetic studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl sulfamates as Steroid sulfatase inhibitors . Bioorganic Chemistry .2022 ;(129):106148-106148

2020 Samir Mehndiratta,Lin MH,Yi-Wen Wu,Chun-Han Chen,Tung-Yun Wu,Chuang KH, Chao MW, Chen YY, Pan SL, Chen MC, Liou JP . N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PDL-1 expression . European Journal of Medicinal Chemistry .2020 ;(185,):111725-111725

9.	2020 Hsu WJ ,Lin MH,Kuo TC ,Chou CM ,Mi FL ,Cheng CH, Lin CW. Fucoidan from Laminaria japonica exerts antitumor effect on angiogenesis and micrometastasis in triple-negative breast cancer in vitro and zebrafish model in vivo . International journal of biological macromolecules .2020 ;(149):600-608

10.	2020 Lee JF ,Chang TY ,Liu ZF,Lee NZ,Yeh YH ,Chen YS, Chen TC , Chou HS, Li TK, Lee SB, Lin MH. Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases . European Journal of Medicinal Chemistry .2020

11.	2020 Wang SW ,Lin MH ,Hsu FC ,Chen MC , Liou JP ,Liu YT, Chen SS, Lee HY*. Synthesis and biological evaluation of 2-quinolineacrylamides . Bioorg. Med. Chem. .2020 ;(28):115250-115250

12.	2020 Hng Y ,Lin MH ,Lin TS,Lu YL,Chang CN,Liu IC, Tsai KC, Liang PH*. Design and Synthesis of 3-Benzylaminocoumarin-7-O-Sulfamate Derivatives as Steroid Sulfatase Inhibitors . Bioorganic Chemistry .2020

13.

2020 Tseng HJ,Lin MH,Shiao YJ,Yang YC,Chu JC,Chen CY, Chen YY, Lin TE, Su CJ, Pan SL, Chen LC, Wang CY, Hsu KC, Huang WJ*. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease . European Journal of Medicinal Chemistry .2020 ;(192)

14.	2019 Lai MJ,Ojha R,Lin MH,Liu YM,Lee HY,Hsu KC, Chang CY, Chen MC, Nepali, K, Chang JY, Liou JP. 1-Arylsulfonyl Indoline-Benzamides as a New Antitubulin Agents, with Inhibition of Histone Deacetylase . European Journal of Medicinal Chemistry .2019 ;(162):612-630

15.	2019 Lin MH,Zheng JH ,Wang JH ,Hsieh YC,Cho EC.. NO2 functionalized coumarin derivatives suppress cancer progression and facilitate apoptotic cell death in KRAS mutant colon cancer . Chemico-Biological Interactions .2019 ;(309):1-10

16.	2019 Kunal Nepali,Lin MH,Chao MW,Peng SJ,Hsu KC,Lin Tony Eight, Chen MC, Lai MJ, Pan SL, Liou JP. Amide-Tethered Quinoline-Resorcinol Conjugates as a new class of HSP90 Inhibitors Suppressing the Growth of Prostate Cancer cells . Bioorganic Chemistry .2019 ;( 91):103119-103119

17.	2018 Tseng SH,Chang TY,Shih CK,Hsieh RH,Chen CW,Chen YC, Lin MH, Chang JS. Effect of Endoplasmic Reticular Stress on Free Hemoglobin Metabolism and Liver injury . Int. J. Mol. Sci. .2018 ;(19):1977

18.	2017 Wu YL,Xie J,An SW,Oliver N,Barrezueta NX,Lin MH, Birnbaume L, Huang CL. Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho . kidney international .2017 ;(91):830-840

19.	2017 Lin HC,Lin MH,Liauo JH,Wu TH,Lee TH,Mi FL, Wu CH, Chen KC, Cheng CH, Lin CW. Antroquinonol, a Ubiquinone Derivative from the Mushroom . Journal of Agricultural and Food Chemistry .2017 ;(65):51-59

20.	2016 Chiang LL,Tseng IJ,Lin PY,Sheu SY,Lin CT,Hsieh YH, Lin YJ, Chen HL, and Lin MH. Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects . molecules .2016 ;(21):100-100

21.	2015 Tseng IJ,Lin PY,Sheu SY,Tung WN,Lin CT,Lin MH. Characterization of Novel Aminobenzylcantharidinimides and Related Imides by Proton NMR Spectra and Their Effects on NO Induction . Journal of the Chinese Chemical Society .2015 ;(62):59-63

22.

2014 Huang YH,Lin MH,Wang PC,Wu YC,Chiang HL,Wang YL, Chang JH, Huang YK, Gu SY, Ho HN, Ling TY. Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells . Molecular Human Reproduction .2014 ;(20):526-537

23.	2014 Lin MH,Cheng CH,Chen KC,Lee WT,Wang YF,Xiao CQ, Lin CW. Induction of ROS-independent JNK-activation-mediated Apoptosis by a Novel Coumarin-derivative, DMAC, in Human Colon Cancer Cells . Chemico-Biological Interactions .2014 ;(218):42-49

24.	2013 Lee LW,Wang GJ,Lin MH,Ju YM,Lin YW,Chen FY, Lee TH. Isolation and Characterization of Sesquiterpenes from Arecophila saccharicola YMJ96022401 with NO production inhibitory activity . Phytochemistry .2013 ;(85):129-136

25.	2012 Hsu FL,Huang WJ,Wu TH,Lee MH,Chen LC,Lu HJ, Hou WC, and Lin MH. Evaluation of antioxidant and free radical scavenging capacities of polyphenolics from Pods of Caesalpinia pulcherrima . Int. J. Mol. Sci. .2012 ;(13):6073-6088

26.	2012 Lin PY,Yeh KS,Su CL,Sheu SY,Chen T,Ou KL, Lin MH, Lee LW. Synthesis and Antibacterial Activities of Novel 4-Hydroxy-7-hydroxy- and 3-Carboxycoumarin Derivatives . Molecules .2012 ;(17):10846-10863

27.	2012 Huang WJ,Wang YC,Chao SW,Yang CY,Chen LC,Lin MH, Hou WC, Chen, MY, Lee TL, Yang P, Chang CI. Synthesis and Biological Evaluation of ortho-ArylN-Hydroxycinnamides as Potent Histone Deacetylase(HDAC) 8 Isoform-Selective Inhibitors . ChemMedChem .2012 ;(7):1815-1824

28.	2012 Chen HL,Lee JF,Tseng SC,Lin MH,Liau WB. Photosensitized growth of TiO2 nanoparticles improved the charge transfer dynamics of a bichromophoric dye . Journal of Luminescence .2012 ;(132):2182-2187

29.	2012 Lee JF,Chen HL,Lee GS,Tseng SC,Lin MH,Liau WB. Photosensized Controlling Benzyl Methacrylate-based Matrix Enhanced Eu3+ Narrow-band Emission for Fluorescence Applications . Int.J. Mol. Sci. .2012 ;(13):3718-3737

30.	2011 Lia MJ,Chang JY,Lee HY,Kuo CC,Lin MH,Hsieh HP, Chang CY, Wu JS, Wu SY, Shey KS, Liou JP. Synthesis and Biological Evaluation of 1-(4’-Indolyl and 6’-Quinolinyl)indoles as a New Class of Potent Anticancer Agents. . Eur. J. Med. Chem. .2011 ;(46):3623-3629

31.	2011 Chin YP,Huang WJ,Hsu FL,Lin YL,Lin MH. Synthesis and Evaluation of Antibacterial Activities of 5, 7-Dihydroxycoumarin Derivatives . Arch Pharm .2011 ;(344):386-393

32.	2011 Lin MH,Chen HY,Liao TH,Huang TC,Lee JA. Determination of time-dependent accumulation of D-lactate in the streptozotocin-induced diabetic rat kidney by column-switching HPLC with fluorescence detection . Journal of Chromatography B .2011 ;(879):3214-3219

33.	2011 Lin MH,Chou YS,Tsai YJ,Chou DS. Antioxidant properties of 5,7-Dihydroxycoumarin derivatives in in vitro Cell-free and Cell-containing Systems . Journal of Experimental and Clinical Medicine .2011 ;(13):126-131

34.	2011 Lin MH,Liu HK,Huang WJ,Huang CC,Wu TH,Hsu FL. Evaluation of the potential hypoglycemic and beta-cell protective constituents isolated from Corni fructus to tackle insulin-dependent diabetes mellitus . J. Agr. Food Chem .2011 ;(59):7743-7751

35.	2011 Liao JH,Wu TH,Hsu FL,Huang YS,Chiang PH,Huang ZY, Huang CH, Wu SH, Lin MH. Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implications for Anti-Cataract Agent . Int. J. Mol. Sci. .2011 ;(10):7059-7076

36.	2010 Huang WJ,Niu HS,Lin MH,Cheng JT,Hsu FL. Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats . J. Nat. Prod. .2010 ;(73):1170-1172

37.	2009 Liao JH,Chen CS,MalerTJ,Liu CY,Lin MH,Wu TH, Wu SH. Astaxanthin Interacts with Selenite and Attenuates Selenite-Induced Cataractogenesis . Chemical Research in Toxicology .2009 ;(22):518-525

38.	2006 Lin CM,Huang ST,Lee FW,Kuo HS,Lin MH. 6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents . Bioorganic & Medicinal Chemistry .2006 ;(14):4402-4409

39.	2005 Lin CH,Liu MC,Lin MS,Lin PL,Chen YH,Chen CT, Chen IM, Tsai MC. Effects of a New Isoquinolinone Derivative on Induction of Action Potential Burst in Central Snail Neuron . Pharmacology .2005 ;(75):98-110

40.	2005 Lin CM,Huang ST,Liang YC,Lin MS,Shih CM,Chang YC, Chen TY, Chen CT. Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages . Planta Med. .2005 ;(71):748-753

41.	2005 Huang YH,Kuo SP,Lin MH,Shih CM,Chu ST,Wei CC, Wu TJ, Chen YH. Signals of Seminal Vesicle Autoantigen Suppresses Bovine Serum Albumin-induced Capacitation in Mouse Sperm . Biochemical and Biophysical Research Communications .2005 ;(338):1564-1571

42.	2004 Lin MS,Hsin LW,Cheng CY. Synthesis of 3-[4-Acyl-2-(1-methoxy-1-methylethyl)morpholin-3-yl]-benzonitriles asd Novel Potassium Channel Openers . Journal of the Chinese Chemical Society .2004 ;(51):157-165

43.	2003 Lin MS. A New Isoquinolinone Derivative with Noble Vasorelaxation Activity . Pharmacology .2003 ;(67):202-210

44.	2002 Lin MS. Synthesis of 1,4-Dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)-2H-isoquinolin-3-one and Related Compounds as Acetylcholine Release Enhancers . The Chinese Pharmaceutical Journal .2002 ;(54):271-281

45.	2001 Sung-Sen Yang, Pauling Chu, Mei-Shan Lin, An Chen, and Yuh-Feng Lin. Two Clinical Variants of Chinese-Herb Nephropathy: Case Reports and Review of the Literature . J. Med. Sci .2001 ;(21):217-22

46.	1996 林美香、蕭超隆、郭憲壽. 雜環昆類之生理活性6-烷硫-7-氨基及6-氨基-7-烷硫-5,8-奎林酮之合成與抗生活性. . JTMC .1996 ;(25):12-21

會議論文 Conference Paper

1.	2005 wei CC,Kuo SP,Chio YY,Wu IZ,Chang CC,Lin MS. Seminal Vesicle Autoantigen Suppresses the Level of Intracellular Calcium, pH Value, cAMP, and Protein Tyrosine Phosphorylation Induced by Bovine Serum Albumin. . The 20th Joint Annual Conference of Biomedical sciences, Taipei, Taiwan.(O91) .2005

林美香(Lin, Mei-Hsiang)　副教授

分享

學經歷

學　歷

本校學術經歷

本校兼職教學行政經歷

其它經歷

專長與研究領域

論文著作

論文 Journal Paper

會議論文 Conference Paper

研究計畫

林美香(Lin, Mei-Hsiang) 副教授

分享

學經歷

學 歷

本校學術經歷

本校兼職教學行政經歷

其它經歷

專長與研究領域

論文著作

研究計畫

林美香(Lin, Mei-Hsiang)　副教授

學　歷