鄭幼文(Cheng, Yu-Wen)　教授

Email
ywcheng@tmu.edu.tw
現   職
藥物科學學科 教授
藥學院 副院長

學經歷

學　歷

畢業學校與學位[修業時間]
國立臺灣大學毒理學研究所 博士
1995/09/01~1999/06/01
國立臺灣大學毒理學研究所 碩士
1993/09/01~1995/06/01
台灣大學昆蟲系 學士
1999/09~2004/06

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科教授
2017/08/01~
藥物科學學科教授
2016/08/01~2017/07/31
藥物科學學科教授
2013/02/01~2016/07/31
藥物科學學科副教授
2012/02/01~2013/01/31
藥學系副教授
2005/02/01~2012/01/31
藥學系助理教授
2000/08/01~2005/02/01

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
藥學院副院長
2024/01/01 ~
(舊)生技醫療產業研發博士學位學程教授
2016/09/01 ~ 2017/08/31
中草藥臨床藥物研發博士學位學程
2013/08/01 ~
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程教授
2013/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
無資料!

專長與研究領域

學門領域
藥學
中醫藥
藥理及毒理
學術專長
基因毒性測試 (Genotoxicity test)
染色體製備(Chromosome aberration test)
微核試驗(Micronucleus test)
安全性評估(safety assessment)
毒性機制探討(Toxic mechanish study)
急性毒性測試(acute toxicity test)
亞急性毒性測試)Subacute toxicity test)
亞慢性毒性測試(Subchronic toxicity test)
慢性毒性測試(Chronic toxicity test)

論文著作

清冊下載

論文 Journal Paper


1. 2024 Wu LH,Cheng YW,Lin FL,Hsu LC,Wang ME,Yen JL, Wang TY, Lin TE, Liu YC, Huang WJ, Hsiao G. A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress . Biomedicine & Pharmacotherapy .2024 ;(260):113037-113041

2. 2024 Li CH,Yang TM,Fittriana I,Fang TC,Wu LH,Hsiao G, Cheng YW. Maintaining KEAP1 levels in retinal pigment epithelial cells preserves their viability during prolonged exposure to artificial blue light . Journal of Photochemistry & Photobiology, B: Biology .2024 ;(260):113037-113041

3. 2023 Lin FL,Cheng YW*,Chen LH,Ho JD, ,Yen JL,,Wang MH, Lee TH*, Hsiao G*. Retinal protection by fungal product theissenolactone B in a sodium iodate-induced AMD model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity . Biomedicine & Pharmacotherapy .2023 ;(158):114138-114148

4. 2023 Chan YJ,Hsiao G,Wan WH,Tsa CH,Kang JJ,,Lee YC, Fang TC, Cheng YW, Li CH. Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17 . Fluids and Barriers of the CNS .2023 ;(20):1-20

5. 2023 Fitriana I,Wu GH,Hsu TJ,Chan YJ,Li CH,Lee CC, Hsiao G, Cheng YW. Activation of aryl hydrocarbon receptor by azatyrosine-phenylbutyric hydroxamide inhibits progression of diabetic retinopathy mice . Biochemical Pharmacology .2023 ;(1):1-13

6. 2021 Chan YJ,Liao PL,Tsai CH,Cheng YW,Lin FL,Ho JD, Chen CY, Li CH. Titanium dioxide nanoparticles impair theinner blood-retinal barrier and retinalelectrophysiology through rapid ADAM17activation and claudin-5 degradation . Particle and Fibre Toxicology .2021 ;(18):1-16

7. 2021 Hsu, TJ,Nepali, K,Tsai, CH,Lin FL,Hsiao, G,Lai, MJ; Cheng YW. The HDAC/HSP90 Inhibitor G570 Attenuated Blue Light-Induced Cell Migration in RPE Cells and Neovascularization in Mice through Decreased VEGF Production . Molecules .2021 ;(26):4359--4378

8. 2020 Tsai CH,Fang TC,Liao PL,Liao JW,Chan YJ,Cheng YW, Li CH. The Powdered Root of Eurycoma longifolia Jack Improves Beta-Cell Number and Pancreatic Islet Performance through PDX1 Induction and Shows Antihyperglycemic Activity in db/db Mice . Nutrients .2020 ;(12):1-16

9. 2020 Chang YD,Li CH,Tsai CH,Cheng YW,Kang JJ,Lee CC. Aryl hydrocarbon receptor deficiency enhanced airway inflammation and remodeling in a murine chronic asthma model . FASEB Journal .2020

10. 2019 Lin FL,Cheng YW,HO JD,Kuo YC,Chiou GCY,Chang HM, Lee TH, Hsiao G. The fungus-derived retinoprotectant theissenolactone C improves glaucomalike injury mediated by MMP-9 inhibition . Phytomedicine .2019 ;(56):207-214

11. 2019 HHL,Liao PL,Cheng YW,Huang SH,Wu CH,Li CH, Kang JJ. Chloramphenicol Induces Autophagy and Inhibits the Hypoxia Inducible Factor-1 Alpha Pathway in Non-Small Cell Lung Cancer Cells . International Journal of Molecular Sciences .2019

12. 2019 Liao PL,Huang SH,Huang WK,Tsai CH,Kang JJ,Wang HP, Cheng YW. Efficacy of azatyrosine-phenylbutyric hydroxamides, a histone deacetylase inhibitor, on chemotherapy-induced gastrointestinal mucositis . International Journal of Molecular Sciences .2019

13. 2019 Lin FL,Yen JL,Kuo YC,Kang JJ,Cheng YW,Huang WJ, Hsiao G. HADC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation . International Journal of Molecular Sciences .2019

14. 2019 Tse LS,Liao PL,Tsai CH,Li CH,Liao JW,Kang JJ, Cheng YW*. Glycemia lowering effect of an aqueous extract of Hedychium coronarium leaves in diabetic rodent models . Nutrients .2019

15. 2019 Lin CH,Wu MR,Huang WJ,Chow DSL,Hsiao G,Cheng YW. Low-luminance blue light-enhanced phototoxicity in A2E-laden RPE cell cultures and rats . International Journal of Molecular Sciences .2019 ;(20):1799-1818

16. 2019 Tsai CH,Lee Y,Li CH,Cheng YW,Kang JJ. Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling . Cell Biology and Toxicology .2019 ;(1):1-11

17. 2019 Tsai CH,Li CH,Liao PL,Chang YW,Cheng YW,Kang JJ. Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric cancer cell migration via PKCa-mediated AHR-HDAC interactions. . BBA- Molecular Cell Research .2019 ;(1867):118567-118571

18. 2019 Chen CY,Liao PL,Tsai CH,Cheng YW,Hwang LL,Li CH. Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity . Particle and Fibre Toxicity .2019 ;(16):37-50

19. 2018 Liao PL,Li CH,Tse LS,Kang JJ,Cheng YW. Safety assessment of the Cistanche tubulosa health food product Memoregain®: Genotoxicity and 28-day repeated dose toxicity test . Food and Chemical Toxicology .2018

20. 2018 Lin FL,Ho JD,Cheng YW, Chiou GCY,Yen JL,Lee TH; Hsiao G. Theissenolactone C Exhibited Ocular Protection of Endotoxin-Induced Uveitis by Attenuating Ocular Inflammatory Responses and Glial Activation . Frontiers in Pharmacology .2018 ;(9):1-14

21. 2018 Wu MR,Lin CH,Ho JD,Hsiao G,Cheng YW. The novel protective effects of Cistanche tubulosa extract against low-luminance blue light induced degenerative retinopathy . Cellular Physiology and Biochemistry .2018 ;(1):63-79

22. 2017 Jan JS ,Chou YC, Cheng YW,Chen CK,Huang WJ, George Hsiao. The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo . International Journal of Molecular Science .2017 ;(29):1394-1414

23. 2017 Li CH,Liu CW,Tsai CH,Peng YJ,Yang YH,Liao PL, Lee CC, Cheng YW, Kang JJ. Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cellsL . Archive in Toxicology .2017 ;(91):2165-2178

24. 2017 Lin FL,Lin CH,Ho JD,Yen JL,Chang HM,George C.Y.Chiou; Cheng YW; Hsiao G. The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration . Scientific Report .2017 ;(23):41086-41099

25. 2017 Tsai CH,Li CH,Cheng YW,Lee CC,Liao PL,Lin CH; Huang SH, Kang JJ. The inhibition of lung cancer cell migration by AhR-regulated autophagy . Scientific Report .2017 ;(14):41927-41941

26. 2017 Lin CH,Wu MR,Li CH,Cheng HW,Huang SH,Tasi CH; Ho JD, Kang JJ; Hsiao G; Cheng YW. Periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis . Toxicological Science .2017 ;(1):196-210

27. 2017 Liao PL,Lin CH,Li CH,Tsai CH,Ho JD, Chiou GCY,,Kang JJ, Cheng YW*. Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy . Scientific Report .2017 ;(7):44985-44997

28. 2016 Lee CC,Yang WH,Li CH,Cheng YW,Tsai CH,Kang JJ. Ligand independent aryl hydrocarbon receptor inhibits lung cancer . Cancer Letter .2016

29. 2015 Lin CH, Liao PL,Hsiao G,Li CH,Huang SH,Tsai CH,Wu MR, Ho JD, Cheng HW, Cheng YW. Long-term fluorometholone topical use induces ganglion cell damage in rats analyzed with optical coherence tomography . Toxicological Science .2015 ;(147):317-325

30. 2015 Li CH,Jhan C,Cheng YW,Tsai CH,Liu CW,Lee CC, Chen RM, Shyu ML, Kang JJ. Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability in mice. . Toxicological Science .2015 ;(148):192-203

31. 2015 Tsai CH,Liao PL,Cheng YW,Lin CH,Huang SH,Li CH, Kang JJ. NcoA2-dependent inhibition of HIF-1α activation is regulated via AhR. . Toxicological Science .2015 ;(418):517-530

32. 2014 Li CH,Liao PL,Yang YT,Huang SH,Lin CH,Cheng YW*, Kang JJ*. Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits . Archives of Toxicology .2014 ;(88):659-671

33. 2014 Wang CL,Chen CK,Wand YH,Cheng YW. In Search of the Active Metabolites of an Anticancer Piperazinedione, TW01003, in Rats. . BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology) .2014 ;(0):0-0

34. 2014 Wang CL,Lee O,Hsiao G,Lian JF,Cheng YW. Novel Piperazinediones as Antitumor Agents . Anticancer Research .2014 ;(34):4013-4019

35. 2014 Lin CD,Kou YY,Liao CY,Li CH,Huang SP,Cheng YW, Liao WC, Chen HX, Wu PL, Kang JJ, Lee CC, Lai CH. Zinc oxide nanoparticles impair bacterial clearance by macrophages. . Nanomedicine (Lond) .2014 ;(9):1327-1339

36. 2014 Liu CW,Li CH,Peng YJ,Cheng YW,Chen HW,Liao PL, Kang JJ, Yun MH. Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer . Oncotarget .2014 ;(5):3880-3894

37. 2013 Lin CH,Li CH,Liao PL,Tse LS,Huang WK,Cheng yw. Silibinin inhibits VEGF secretion and age-related macular degeneration in a hypoxia-dependent manner through the PI-3 kinase/Akt/mTOR pathway . British Journal of Pharmacology .2013 ;(168):920-931

38. 2013 Li CH,Liao JW,Liao PL,Tse LS,Lin CH,Kang JJ, Cheng YW. Evaluation of acute, 13-week subchronic toxicity and genotoxicity of the powdered root of Tongkat Ali (Eurycoma longifolia Jack) . Evid Based Complement Alternat .2013 ;(1):1-11

39. 2012 Chung CL,Sheu JR,Chen WL,Chou YC,Cheng YW,Hsiao G. Histone deacetylase inhibitor CBHA attentuates PAI-1 expression in human pleural mesothelial cells . American Journal of Respiratory Cell and Molecular Biology .2012 ;(46):437-445

40. 2012 Lee WR,Chung CL,Hsiao CJ,Chou YC,Cheng YW,Hsiao G. Suppression of matrix metalloproteinase-9 expression by andrographolide in . Phytomedicine .2012 ;(19):270-277

41. 2012 Liao PL,Li CH,Chang CY,Liu SR,Lin CH,Chneg YW. Anti-ageing effects of alpha-naphthoflavone on normal and UVB-irradiated human skin fibroblasts . Experimental Dermatology .2012 ;(21):546-548

42. 2012 Li CH,Liao PL,Shyu ML,Huang SH,Cheng YW,Kang JJ. Zinc oxide nanoparticles induced intercellular adhesion molecule 1 expression requires Rac1/Cdc42, mixed-lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells. . Toxicological Science .2012 ;(126):162-172

43. 2012 Lee CC,Huang SH,Yang YT,Cheng YW,Li CH,Kang JJ. Motorcycle exhaust particles up-regulate expression of vascular adhesion molecule-1 and intercellular adhesion molecule-1 in human umbilical vein endothelial cells . Toxicology in Vitro .2012 ;(26):552-560

44. 2012 Li CH,Shen CC,ChengYW,Huang SH,Wu CC,Kang JJ. Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice . Nanotoxicology .2012 ;(6):746-756

45. 2011 Lee CC,Kang JJ,Chiang BL,Wang CN,Cheng YW. Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction . Life Science .2011 ;(89):364-370

46. 2011 Wu CJ,Chou YC,Cheng YW,Hsiao CJ,Hsiao G. Aristolochic acid downregulates monocytic matrix metalloproteinase-9 by inhibiting nuclear factor-κB activation . Chem-Biol Interaction .2011 ;(15):209-219

47. 2011 Cheng YW,Cheah KP,Lin CW,Lin JS,Yu WY,Hu CM. Myrrh mediates haem oxygenase-1 expression to suppress the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. . J Pharm Pharmacol. .2011 ;(63):1211-1218

48. 2010 Cheng YW#; Li CH#,Hsu YT,Hsu YJ,Liao PL,Kang JJ. Benzo[a]pyrene inhibits angiogenic factors-induced αvβ3 integrin expression, neovasculogenesis and angiogenesis in human umbilical vein endothelial cells. . Toxicological science. .2010 ;(118):544-553

49. 2010 Li CH,Cheng YW,Liao PL,Yang YT,Kang JJ. Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression and solid-tumor cell invasion . Toxicological Science .2010 ;(116):140-150

50. 2010 Liao PL,Cheng YW,Lee CH,Kang JJ. 7-Ketocholesterol and cholesterol-5,6-epoxide induce smooth muscle cell migration and proliferation through the Epidermal Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt signaling pathways . Toxicology Letters .2010 ;(197):88-96

51. 2010 Cheng YW,Lou HY,Lee SS,Liao JW,Cheng HW,Li CH, Liao PL, Kang JJ. Safety assessment of musl substitute from Nutria of Myocastor Coypus in mice . Journal of Food and Drug Analysis .2010 ;(18):380-390

52. 2010 Lee CC,Wang CN,Liao YT,Kang JJ,Liao JW,Cheng YW. Shikonin Inhibited Bone Marrow-Derived Dendritic Cell Maturation and Suppressed Allergic Airway Inflammation in a Murine Model of Asthma. . British Journal of Pharmacology. .2010 ;(16):1496-1511

53. 2010 Cheng YW,Chiou George CY. Proloiferation of retinal pigment epithelial cells induced vy (R,R)-XY-10 and (S,S)-XY-10 and their action mechanisms . International Journal of Ophthalmology .2010 ;(3):9-13

54. 2010 Li CH,Cheng YW,Liao PL,Kang JJ. Translocation of p53 to Mitochondria Is Regulated by Its Lipid Binding Property to Anionic Phospholipids and It Participates in Cell Death Control . Neoplasia .2010 ;(12):150-60

55. 2009 Lin MC,Cheng HW,Tsai YC,Liao PL,Cheng YW*. Podophyllin, but not the constituents of quercetin and kaempferol, induced genotoxicity in vitro and in vivo through ROS production . Drug and Chemical Toxicology .2009 ;(32):68-76

56. 2009 Cheng YW,Liao PL,Li CH,Lo YL,Kang JJ. Cholesterol-3-beta,5-alpha,6-beta-triol induced PI3K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells . Toxicology Letters .2009 ;(28):172-178

57. 2009 Chen YT,Hung DZ,Chou CC,Kang JJ,Cheng YW,Liao JW. Vasorelaxation effects of 2-chloroethanol and chloroacetaldehyde in the isolated rat aorta rings . Journal of Health Science .2009 ;(55):525-531

58. 2008 Cheng YW,Chiou CY. Antioxidant effect of hydralazine on retinal pigment epithelial cells and its potential therapy of age-relative mucular degeneration . International Journal of Ophthalmology .2008 ;(8):1059-1064

59. 2008 Lin MC,Lin JH,Chen SK,Cheng YW,Cheng HW. Stimultaneous determination of podophyllotoxin, quercetin and kaempferol in podophyllin by liquid chromatography Tandem Mass Spectrometry . Journal of Food and Drug analysis .2008 ;(16):29-40

60. 2008 Cheng YW,Chang CY,Lin KL,Hu CM,Lin CH,Kang JJ*. Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kB signaling . Journal of Ethanopharmacology .2008 ;(120):264-271

61. 2008 Lee CC,Cheng YW,Liao JW,Chiang BL,Kang JJ. Motorcycle exhaust particles augment antigen-induced airway inflammation in BALB/c mice. . J Toxicol Environ Health A. 2008;71(6):405-12. .2008 ;(71):405-412

62. 2006 Kang JJ,Lee PJ,Chen YJ,Cheng HW,Lee CC,Li CH and Cheng YW. Naphthazarin and methylnaphthazarin cause vascular dysfunction by impairment of endothelium-derived nitric oxide and increased superoxide anion generation . Toxicology in Vitro .2006 ;(20):43-51

63. 2006 Tzeng SL,Cheng YW,Li CH,Lin YS,Hsu HC,Kang JJ*. Physiological and functional interactions between TCF4 and DAXX in colon cancer cells . Journal of Biological Chemistry .2006 ;(281):15405-15411

64. 2005 Lee CC,Cheng YW,Kang JJ. Motorcycle Exhaust Particles Induce IL-8 Production Through NF-kB Activation in human Airway Epithelial Cells . J .Toxicol. Environ. Health. .2005 ;(68):1537-1555

65. 2005 Hu CM,Cheng YW,Cheng HW,Liao JW,Kang JJ. Induction of Contracture and extracellular Ca2+ influx in Cardiac Muscle by Sanguinarine: A Study on Cardiotoxicity of Sanguinarine . Journal of Biomedical Science .2005 ;(12):399-407

66. 2005 Li CH,Tzeng SL,Cheng YW,Kang JJ. Chloramphenicol-induced mitochondrial stressincreases P21 expression and prevents cell apoptosis through a P21dependent pathway . Journal of Biological Chemistry 280 .2005 ;(28):26193-26199

67. 2005 Cheng YW,Knag JJ,Shih YL,LO YL,Wang CF. Cholesterol-3-beta, 5-alpha, 6-beta,-triol induced genotoxicity through reactive oxygen species formation . Food and Chemical Toxicology .2005 ;(43):617-622

68. 2004 Cheng YW,Lee WW,Li CH,Lee CC,Kang JJ*. Genotoxicity of motorcycle exhaust particulate in vivo and in vitro . Toxicological Science .2004 ;(81):103-111

69. 2004 Hu, C.M., Cheng, Y.W., Cheng, H.W. and Kang, J.J.. Impairment of vascular function of rat aorta in an endothelium-dependent manner by Shikonin/alkanin and its derivatives from roots of Macrotomia euchroma . Planta Medica .2004 ;(70):23-28

70. 2004 Lee CH,Lee CC,Cheng YW,Juang HA,Kang JJ. Activation and up-regulation of nitric oxide synthase in human umbilical vein endothelial cells . Toxicology Letters .2004 ;(151):367-374

71. 2003 Hu, C.M., Kang , J.J., Lee, C.C., Li, C.H. and Cheng Y.W.. Induction of vasorelaxation through activation of nitric oxide synthase in endothelial cells by brazilin . European Journal of Pharmacology .2003 ;(468):37-45

72. 2003 Hsiao, G., Shen, M.Y., Chang, W.C., Cheng, Y.W., Pan, S.L., Kuo, Y.H., Chen, T.F. and Sheu ,J.R.. A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells . Biochem Pharmacol .2003 ;(65):1383-1392

73. 2003 Cheng, YW., Li, C.H., Lee, C.C. and Kang, J.J.. Alpha-Naphthoflavone Induced Vasorelaxation Through the Induction of Extracellular Calcium Influx and Nitric Oxide Formation in Endothelium . Naunyn-Schmiedeberg's Archives of Pharmacology. .2003 ;(368):377-385

74. 2002 Chen SS, Chang PC, Cheng YW, Tang FM. and Lin YS.. Supression of the STK15 oncogenic activity requires a transactivation-independent P53 function. . EMBO Journal .2002 ;(21):4491-4499

75. 2001 Hsiao G., Teng CM., Sheu JR., Cheng YW., Lam KK., Lee YM., Wu TS. and Yen MH.. Cinnamophilin as a novel antiperoxidative cytoprotectant and free radical scavenger . Biochim. Biophys. Acta. .2001 ;(1525):77-88

76. 2001 CM Hu, HW Cheng, YW Cheng and JJ Kang. Mechanisms underlying the induction of vasorelaxation in rat thoracic aorta by sanguinarine. . . Japanese Journal of Pharmacology .2001

77. 2000 Liao JW, Kang JJ, Liu SH, Jeng CR, Cheng YW, Hu CM, Tsai SF, Wang SC, Pang VF. Effects of cartap on isolated mouse phrenic nerve diaphragm and its related mechanism. . Toxicol Science .2000 ;(55):453-459

78. 2000 C.M. Hu, H.W. Cheng, Y.W.Cheng and J.J. Kang.. Induction of skeletal muscle contracture and calcium release from isolated sarcoplasmic reticulum vesicles by sanguinarine . British Journal of Pharmacology .2000

79. 1999 Cheng Y.W. and Kang, J.J.. Inhibition of Agonist-induced vasocontraction and impairment of endothelium-dependent vasorelaxation by extract of motorcycle exhaust particles in vitro. . Journal of Toxicology and Environmental Health, Part A .1999

80. 1998 Kang, J.J., Cheng, Y.W. and Fu, W.M.. Studies on neuromuscular blockade by boldine in the mouse phrenic nerve-diaphragm . Japanse Journal of Pharmacology .1998

81. 1998 Kang, J.J., Cheng, Y.W. and Fu, W.M.. Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from skeletal muscle . Planta Medica .1998

82. 1998 Cheng, Y.W. and Kang, J.J.. Emodin-induced muscle contraction of mouse diaphragm and the involvement Ca2+ influx and Ca2+ release from sarcoplasmic reticulum . British Journal of Pharmacology .1998

83. 1998 Kang, J.J., Lin, S.H., Chen, I.L., Cheng, Y.W. and Lin-Shiau, S.Y.. Comparative studies on the induction of muscle contracture in mouse diaphragm and Ca2+ release from sarcoplasmic reticulum vesicles by oragnotin compounds . Pharmacology and Toxicology .1998

84. 1997 Ueng, T.H., Kang, J.J., Wang, H.W., Cheng Y.W. Chiang, L.Y.. Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60. . Toxicology Letters .1997

85. 1997 Kang, J.J., Chen, I.L. and Cheng, Y.W.. 3. Induction of calcium release from isolated sarcoplasmic reticulum by triphenyltin. . Journal of Biochemistry (Tokyo) .1997

86. 1997 Cheng, Y.W. and Kang, J.J.. Mechanism of vasorelaxation of thoracic aorta caused by xanthone, . . European Journal of Pharmacology .1997

87. 1997 Kang, J.J. and Cheng, Y.W.. Polycyclic aromatic hydrocarbons-induced vasorelaxation through induction of nitric oxide formation in endothelium of rat aorta. . Toxicology Letters .1997

88. 1996 Kang, J. J., Cheng, Y. W., Ko, F.N., Kuo, M.L., Lin, C.N. and Teng, C.M.. Induction of calcium release from sarcoplasmic reticulum of skeletal muscle by xanthone and norathyriol . Br. J. Pharmacol. .1996

89. 1996 Kang, J.J., Chen, Y.C., Kuo, W.C., Chen, T., Cheng, Y.W., Kuo, M.L. and Ueng, T.H.. Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae Scabrae Radix in rat liver . American Journal Chinese Medicine .1996 ;(XXIV):19-29

會議論文 Conference Paper


1. 2023 Hsu TJ ,Wu CH ,Ida Fitriana,Hsiao G,Chan YJ,Liang CJ, Lou CH, Kang JJ, Cheng YW*. The Novel Aryl Hydrocarbon Receptor Activator, Aza-PBHA, attenuated diabetes-induced capillary loss and inflammation of retina in type II diabetic mice . JOST 2023 The 50th Anniversary Annual Meeting of the Japanese Society of Toxicology .2023

2. 2023 Chan YJ ,Chen YY ,Chen NN ,Hsu TJ ,Liang CJ ,Lou CH, Li CH, Kang JJ, Hsiao G*, Cheng YW*. The potential therapeutic mechanisms of Aza-PBHA regulates aryl aromatic hydrocarbon receptor in blue light-induced retinopathy . JOST 2023 The 50th Anniversary Annual Meeting of the Japanese Society of Toxicology .2023

3. 2023 Chen NN,Hsiao G,Chan YJ,Hsu TJ,Liang CJ,Lou CH, Chen CC*, Cheng YW*. The development of medicinal fungi Cordyceps cicadae and Hericium erinaceus in the therapeutic application of retinopathies . JOST 2023 The 50th Anniversary Annual Meeting of the Japanese Society of Toxicology .2023

4. 2023 Hsu CH , Ho HO ,Liang CJ ,Chan YJ, Hsu TJ ,Lou CH, Sheu MT*, Cheng YW *. Development of thermosensitive in situ poloxamer gels as ocular drug delivery systems of phenylbutyrate sodium for the treatment of open-angle glaucoma . JOST 2023 The 50th Anniversary Annual Meeting of the Japanese Society of Toxicology .2023

5. 2023 Su EP ,Wei PS ,Sheu MT*,Cheng YW* . Development of novel two-step dual-crosslinkable hyaluronic acid (dcHA) and validation of its biocompatibility as a new generation dermal filler . JOST 2023 The 50th Anniversary Annual Meeting of the Japanese Society of Toxicology .2023

6. 2023 Li CH ,Wan WN ,Chan YJ ,Yang TM ,Lai YT ,Hsiao G, Cheng YW . Blue light dissociates GNAZ-ADAM17 protein complex, accelerates claudin-5 degradation, and increases retinal endothelium permeability . JOST 2023 The 50th Anniversary Annual Meeting of the Japanese Society of Toxicology .2023

7. 2023 Yang TM,Chan YJ ,Wan WN,Wu DY ,Hsiao G,Cheng YW, Li CH*. Aryl Hydrocarbon Receptor Defect Induces Intercellular Adhesion Molecule 1 Expression and Impairs the Physiological Function of Retinal Pigment Epithelial Cell . JOST 2023 The 50th Anniversary Annual Meeting of the Japanese Society of Toxicology .2023

8. 2023 Low-illuminated blue light destroys endothelial tight junction and attenuates retinal phototransduction through the disturbance on GNAZ-ADAM17 axis . Cold Spring Harbor Laboratory: Mechanisms of Eukaryotic Transcription, NewYork, USA. .2023

9. 2022 Chan YJ ,Liao PL,Tsai CH,Cheng YW,Lin FL,Ho JD, Chen CY, Li CH*. Titanium dioxide nanoparticles impair the inner blood retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin5 degradation. . The 39th Congress of the International Union of Physiological Sciences(Abstract) .2022

10. 2022 Chiu SJ,Chou HC,Chan YJ,Hsu TJ,Hu TM,Tsai CH, Hsiao G, Yang TM, Kang JJ*, Cheng YW*. Nitric oxide-releasing silica nanoparticles diminish long-term blue light-induced damage of RPE-19 cells and mice retina by promoting antioxidant response and vascular circulation. . Cold Spring Harbor meeting: Single Biomolecules 2022 .2022

11. 2022 Chen CK,Lin FL,Yen JL,Lee TH,Cheng YW*,Hsiao G*. A novel fungal component dehydrocurvularin abrogates SARSCoV-2 spike 1 protein-induced activation through STAT/NF-κB inhibition in monocytic and microglial cells. . Cold Spring Harbor meeting: Single Biomolecules 2022 .2022

12. 2022 Chan YJ ,Wan WN,Yang TM,Liao PL,Tsai CH,Kang JJ, Cheng YW, Li CH*. The effects of titanium dioxide nanoparticles on the physiological function of the vascular endothelial cell. . 14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology (2022 ICCB & APOCB JOINT MEETING) .2022

13. 2022 Yang TM,Chan YJ,Wan WN,Kang JJ,Hsiao G,Cheng YW*, Li CH*. Aryl Hydrocarbon Receptor Defect Impairs the Physiological Function of Retinal Pigment Epithelial Cell Involving an Induction of Integrin Beta 3 and Intercellular Adhesion Molecule 1. . 14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology (2022 ICCB & APOCB JOINT MEETING) .2022

14. 2022 Wan WN,Chan YJ,Yang TM,Tsai CH,Kang JJ,Hsiao G, Cheng YW*, Li CH*. Blue light exposure induces the collapse of inner blood-retinal barrier by accelerating endothelial claudin-5 degradation through the disturbance of Gz protein and the activation of ADAM17. . 14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology (2022 ICCB & APOCB JOINT MEETING .2022

15. 2021 Tsai CH,Fang TC,Liao PL,Chan YJ,Cheng YW,Li CH. The powdered root of Eurycoma longifolia Jack improves b-cell number and pancreatic islet performance through PDX1 induction and shows antihyperglycemic activity in db/db mice . The 14th Meeting of the Asia Pacific Federation of Pharmacologists 2021, Taipei, Taiwan. (Poster-E24) .2021

16. 2021 The Mechanism and Potential Efficacy of Aryl Hydrocarbon Receptor Activator, Aza-PBHA in Diabetic Retinopathy. . The 14th Meeting of the Asia Pacific Federation of Pharmacologists 2021, Taipei, Taiwan. (Poster-I39). .2021

17. 2021 Lin FL,Chen LH,HㄟJD,Wu LH,Kuo YH,Cheng YW, Hsiao G. The Protective Effects and Mechanisms of Fungal Ingredient 3,4-Dihydroxybenzalacetone against Blue Light-Emitting Diode Light-induced Retinal Photoreceptor Cell Damage and Degeneration in Vivo. . The 14th Meeting of the Asia Pacific Federation of Pharmacologists. 2021, Taipei, Taiwan. (Poster-E049). .2021

18. 2019 Chi-Hao Tsai,Yi Lee,Yu-Wen Cheng,Jaw-Jou Kang. AhR-mediated regulation of SOCS3-STAT3 axis is involved in downregulation of B[a]P-induced retinal lesion. . 15th International Congress of Toxicology .2019

19. 2019 Tai-Ying Chen,Ling-Shan Tse,Chi-Hao Tsai,Ching-Chiung Wang,Yu-Wen Cheng,Po-Lin Liao, and Jaw-Jou Kang. Toxicity Evaluation of Deer Velvet Antler Extract . TTQAS 2019年 創新食品(保健食品)的開發及衛生安全檢驗論壇 .2019

20. 2019 Fan-Li Lin,Jaw-Jou Kang,Jing-Lun Yen,Jau-Der Ho,Chung-Yang Huang,Yu-Wen Cheng. Selective Blockade of HDAC8 by BMX Attenuates Laser-Induced Choroidal Neovascularization Model in Mice . The Thirty Four-four Joint Annual Conference of biomedical Science .2019

21. 2019 Fan-Li Lin,George Hsiao,Jing-Lun Yen,Yu-Cheng Kuo,Yu-Wen Cheng,Wei-Jan Huan, Jaw-Jou Kang. Novel HADC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-induced Mouse Model of Neuroinflammation and Microglial Activation through Downregulation of STAT Signaling . Yu-Wen Cheng .2019

22. 2019 Yi-Shiou Wei,Chi-Hao Tsai,Yu-Wen Cheng,Jaw-Jou Kang. Up regulation of Naphthalene-mediated NF-kB signaling is associated with CYP2F1 expression in retina pigment epithelium cell . The Thirty Four-four Joint Annual Conference of biomedical Science .2019

23. 2019 Chi-Hao Tsai,Che-Jui Liang,Yu-Wen Cheng,Jaw-Jou Kang. Aryl Hydrocarbon Receptor Mediates Epigenetic Regulation during HDAC-Inhibitor Treatment in Lung Cancer Cell Lines . The Thirty Four-four Joint Annual Conference of biomedical Science .2019

24. 2019 Li, Ching-Hao,Kang, Jaw-Jou,Cheng Yu-Wen . Safety Evaluation of Chinese Medicine products using Pb4O3, be called HuangDan( 黃丹 ) . The Thirty Four-four Joint Annual Conference of biomedical Science (Taiwan) .2019

25. 2018 Po-Lin Liao,Chi-Hao Tsai,Ling-Shan Tse,Shih-Hsuan Huang,Ching-Hao Li,Jaw-Jou Kang*, and Yu-Wen Cheng*. Therapeutic potential of a novel azatyrosine analogue on early-stage diabetic retinopathy . The 8th International Congress of Asian Society of Toxicology (ASIATOX-VIII) .2018

26. 2018 Chi-Hao Tsai,,Ching-Hao Li,Chen-Chen Lee,Yu-Wen Cheng,Jaw-Jou Kang. Benzo[a]pyrene- induced cell migration associated with AhR expression level in lung cancer cell. Poster presentation . The Thirty Three-four Joint Annual Conference of biomedical Science .2018

27. 2018 Huang SH,Li CH,Kang JJ,Cheng YW. Comparison of the Solubility and Pharmacokinetics of Arsenic from Realgars( 雄黃 ) . The Thirty Three-four Joint Annual Conference of biomedical Science .2018

28. 2018 Chi-Hao Tsai,Che-Jui Liang,Po-Lin Liao,Yu-Wen Cheng,Jaw-Jou Kang*. AhR plays a key role on epigenetic regulation within HDAC inhibitor treatment . 18th World Congress of Basic and Clinical Pharmacology .2018

29. 2016 Liao PL,Li CH,Yang CH,Kang JJ,Cheng YW. Therapeutic potential of shikonin in early-stage retinopathy . International Conference on Engineering and Natural Science– Summer Session .2016

30. 2016 Li CH,Liu CW,Tsai CH,Liao PL,Cheng YW. Aryl hydrocarbon receptor overexpression activates glycogen synthase kinase 3 beta, reduces vimentin level, and suppress epithelial-mesenchymal transition in non-small cell lung cancer cells. International . International Conference on Engineering and Natural Science– Summer Session .2016

31. 2016 Tsai CH,Li CH,Liao PL,Cheng YW,Kang JJ. Studies of the autophagy-affected EMT by AhR regulation in lung cancer cell. . International Conference on Engineering and Natural Science– Summer Session .2016

32. 2016 Jan JS,Chou YC,Cheng YW,Huang WJ,Hsiao G. A novel HDAC-8 inhibitor, WK2-16, attenuates lipopolysaccharide-activated matrix metalloproteinase 9 expression in human monocytic cell and improves septic injuries in vivo. . International Conference on Engineering and Natural Science– Summer Session .2016

33. 2016 Lin FL,Lin CH,Ho JD,Cheng YW,Hsiao G. A natural retinoprotectant, Chrysophanol, attenuated N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis and retinopathies. . International Conference on Engineering and Natural Science– Summer Session .2016

34. 2016 Huang SH,Lin CH,Kang JJ,Cheng YW. Assessment of the solubility and bioavailability of arsenic in retail realgar (As4S4). . International Conference on Engineering and Natural Science– Summer Session .2016

35. 2015 Liao PL,Li CH,Hsaio G,HO JD,Tsai CH,Cheng YW, Kang JJ. Shikonin exert therapeutic potential in early-staged diabetic retinopathy. . International Biotechnology, Chemical Engineering and Life Science .2015 ;(P976)

36. 2015 Lin CH,Liao PL,Cheng HW,Li CH,Hsaio G,Cheng YW. Long-Term Fluorometholone Topical Use Induces Ganglion Cell Damage in Rats Analyzed with Optical Coherence Tomography . International Biotechnology, Chemical Engineering and Life Science Conference .2015 ;(P979)

37. 2015 Lin FL,Ho JD,Lin CH,Liao PL,Yen JL,Cheng YW, Hsiao George. Chrysophanol Blocked N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Apoptosis and Attenuated Neuroin flammatory Responses via Microglial Inhibition. . International Biotechnology, Chemical Engineering and Life Science Conference. .2015

38. 2015 Li CH,Jhan C,Tsai CH,Cheng YW,Kang JJ. Study on the Mechanism of Cross-Talk between AhR and Autophagy on Cell Motility. . International Biotechnology, Chemical Engineering and Life Science Conference. .2015

39. 2015 Tsai CH,Li CH,Liao PL,Lin CH,Yang WH,Cheng YW, Kang JJ. Study on the Mechanism of Cross-Talk between AhR and Autophagy on Cell Motility. . International Biotechnology, Chemical Engineering and Life Science Conference. .2015

40. 2014 Cheng YW,Lin FL,Wu JW,Yen CL,Chiang HT,Hsiao George. The inhibitory effects of caffeic acid phenethyl ester on microglial activation and its protective actions on neuroinflammation in vivo . Glia in Health & Disease meeting (2014) Cold Spring Harbor, NY, USA. (P23) .2014

41. 2014 Hsiao G,Chou YC,Wu JW,Lin FL,Cheng YW,Kuo YH. The protective mechanisms of ergostatrien-3b-ol on intracerebral hemorrhage-induced brain injury and microglia activation . Glia in Health & Disease meeting (2014) Cold Spring Harbor, NY, USA. (P64) .2014

42. 2013 George H,Chang WR,Hsiao CJ,Wang HP,Cheng YW. Phenylbutyrylhydrocamic acid attenuates matrix metalloproteinase-9 expression in human monocytic THP-1 cells via inhibition of ERK MAPK activation . Mechanism of Eukaryotic Transcription meeting (2013) Cold Spring Harbor, NY, USA. (Abstract) .2013

43. 2013 George H,Lee TH,Jan JS,Hsiao CJ,Cheng YW. Heak shock protein 90 inhibitor radicicol attenuates matrix metalloproteinase expression in human monocytic cells . IMMUNOLOGY 2013; Honolulu, Hawaii, USA. P 4153 .2013 ;(P4153)

44. 2012 Cheng YW. 安全性評估的重要性 (Oral Presentation) . 天然來源健康食品之開發與認證, 工業技術研究院, 新竹, Taiwan. .2012

45. 2012 Cheng YW. 臺灣非傳統食品原料 管理架構與法規 . 兩岸飛傳統食品原料管理研討會 (Oral presentation)Taipei, Taiwan. .2012

46. 2012 Cheng YW. 奈米材料的安全性 (Oral Presentation) . 奈米食品管理教育訓練課程, 國立臺灣大學食品科技研究所, Taipei, Taiwan. .2012

47. 2012 Cheng YW. 健康食品之安全評估與審查經驗分享 (Oral Presentation) . 臺灣製藥同業工會, Taipei, Taiwan. .2012

48. 2011 Cheng YW. 健康食品與藥物的不良交互作用(Oral Presentation), . 食品與藥品成分交互作用產生人體副作用研討會 (Oral Presentation), 台北醫學大學, Taipei, Taiwan. .2011

49. 2011 Cheng YW. 保健食品實務研討會「保健食品藍海策略-從品質管理技術談起」(Oral Presentation) . 經濟部工業局, 中華穀物食品工業研究所, Taipei, Taiwan. .2011

50. 2011 Cheng YW. 加工改良傳統與非傳統食品原料安全性評估研討會(Oral Presentation) . 食品藥物管理局, Taipei, Taiwan. .2011

51. 2010 Cheng YW. Safety studies and related topic on food with nanoparticles . 2010 International Symposium of Regulatory Science on Food, Drugs and Medical Devices Containing Nanoscale Materials (Oral presentation) Taipei, Taiwn .2010

52. 2010 Cheng YW. 奈米藥品(含中藥)現階段之毒性資訊及風險評估 (Oral Presentation) . 工研院, Taipei, Taiwan. .2010

53. 2009 Cheng YW,Chou YC,Lin FL,Kuo YH,Hsiao G. Nuclear Targeted Inhibition of NF-kappaB on MMP-9 production by EK5 in Human Monocyte. . The 9th World Congress on Inflammation 2009, Tokyo, Japan. (Abstract) .2009 ;(00267)

54. 2009 Liao PL,Cheng YW,Kang JJ. Effect of oxysterols on atherosclerosis . The Twenty-four Joint Annual Conference of biomedical Science (Abstract) .2009

55. 2008 Chou YC,Yen YH,Sheu JR,Cheng YW,Kou YH,Hsiao G. A phenylalkylamine compound EK5 abrogates matrix metalloproteinase-9 expression by inhibition of NF-kB activation in human monocytic THP-cells. . The Twenty-three Joint Annual Conference of biomedical Science (abstract), 2008; P29. .2008 ;(P29)

56. 2008 Liao PL,Cheng YW,Kang JJ. Effect of oxysterol on atherosclerosis . The Twenty-three Joint Annual Conference of biomedical Science (Abstract) .2008 ;(P407)

57. 2007 Tzeng SL,Wang CW,ChengYW,Kang JJ. The role of DAXX in colon tumorgenesis . The Twenty-two Joint Annual Conference of biomedical Science (Abstract) .2007 ;(O066)

58. 2007 Tzeng SL,Cheng YW,Li CH,Lin YS,HSu HC,Kang JJ. Physiological and functional interactions between TCF4 and DAXX in colon cancer cells . The Twenty-two Joint Annual Conference of biomedical Science (Abstract) .2007 ;(P531)

59. 2007 Lin MC,Cheng HW,Lin JH,Chen SK,Tsai YC,Liao PL, Cheng YW. Podophyllin, but not the constitute of quercetin and kaemperol, induced genotoxicity in vitro and in vivo through ROS production . The Twenty-two Joint Annual Conference of biomedical Science (Abstract) .2007 ;(P707)

60. 2005 Lin YY,Lin YS,Liu HE,Cheng YW,Sheu JR,G Hsiao. Investigation of the inhibitory mechanisms of haloperidol on matrix. . The Twenty Joint Annual Conference of biomedical Science (Abstract) .2005 ;(P47)

61. 2005 Huang LC,Chou YC,Cheng YW,Lin YS,Sheu JR,Hsiao G. Effect of benzydamine on monocytic matrix metalloproteinase-9 activation and vasorelaxation. . The Twenty Joint Annual Conference of biomedical Science (Abstract) .2005 ;(P47)

62. 2004 Chu CL,Lin YH,Shih YL,Cheng YW,G Hsiao. Investigation of the defferent effects of ammonium pyrrolidinedithiocarbamate and probucol on matrix metalloproteinase activation between primary and cell line-human endothelial cells . The Nineteenth Joint Annual Conference of biomedical Science (Abstract) .2004 ;(P69)

63. 2004 Cheng YW,Wang CC,Li CH,Lin HY,Lee CC,Kang JJ. The role of MAPK kinase in oxysterols induced cytotoxicity in human umbilical vein endothelial cells. . The Nineteenth Joint Annual Conference of biomedical Science (Abstract) .2004 ;(P554)

研究計畫

計畫名稱
113 委託執行動物活體藥效試
補助單位
財團法人工業技術研究院
計畫名稱
113 視覺循環抑制劑藉由調控褐紫質堆積對抗藍光誘發之乾性黃斑部病變於離體色素上皮細胞與活體小鼠視網膜之功效探討(2/3)
補助單位
國家科學及技術委員會
計畫名稱
113 「視覺循環抑制劑藉由調控褐紫質 堆積對抗藍光誘發之乾性黃斑部病變於離體色素上皮細胞與 活體小鼠視網膜之功效探討」-延攬詹燕茹
補助單位
國家科學及技術委員會
計畫名稱
112 體外執行藥物功效驗證
補助單位
財團法人工業技術研究院
計畫名稱
112 執行動物活體藥效試驗 (ITRIX應用於藍光誘發視網膜病變功效性試驗)
補助單位
財團法人工業技術研究院
計畫名稱
112 視覺循環抑制劑藉由調控褐紫質堆積對抗藍光誘發之乾性黃斑部病變於離體色素上皮細胞與活體小鼠視網膜之功效探討(1/3)
補助單位
國家科學及技術委員會
計畫名稱
112 貴校隨專題研究計畫延攬詹燕茹君參與「視覺循環抑制劑藉由調控褐紫質堆積對抗藍光誘發之乾性黃斑部病變於離體色素上皮細胞與活體小鼠視網膜之功效探討」研究計畫案，申請本會補助，業經核定以「博士級研究人員」資格補助(NSTC 112-2811-B-038-012)，補助項目為研究費、年終獎金、離職儲金、保險費等
補助單位
國家科學及技術委員會
計畫名稱
112 貴機構依本會「補助國內研究生出席國際學術會議」申請費用補助案(研究生：新藥研發產業博士學位學程博士班許泰儒君)，業經核定，請查照辦理。
補助單位
國家科學及技術委員會
計畫名稱
111 委託執行動物活體藥效試驗
補助單位
財團法人工業技術研究院
計畫名稱
111 Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討(3/3)
補助單位
國家科學及技術委員會
計畫名稱
111 芳香烴受體於眼科疾病之治療潛力機制探討-芳香烴受體於藍光誘發視網膜病變之治療潛力機制探討(3/3)
補助單位
國家科學及技術委員會
計畫名稱
111 貴機構(藥學系（所）鄭幼文教授)延攬詹燕茹君參與「Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討」研究計畫案，申請本會補助，業經核定以「博士級研究人員」資格補助(NSTC 111-2811-B-038-027)，補助項目為研究費、年終獎金、離職儲金、保險費等
補助單位
國家科學及技術委員會
計畫名稱
111 112年度【產學合作計畫-藥用真菌猴頭菇與蟬花應用於神經損傷性視網膜病變功效開發】
補助單位
國家科學及技術委員會
計畫名稱
111 112年度【產學合作計畫－藥用真菌猴頭菇與蟬花應用於神經損傷性視網膜病變功效開發】
補助單位
葡萄王生技股份有限公司
計畫名稱
111 日本毒理學會50週年年會（JSOT 2023）(研究生：生藥學研究所博士班IDA FITRIANA君)
補助單位
國家科學及技術委員會
計畫名稱
110 藥物於眼科雷射誘發脈絡膜新生血管試驗研究計畫
補助單位
上毅生物科技股份有限公司
計畫名稱
110 貴機構(藥學系（所）鄭幼文教授)隨專題研究計畫延攬詹燕茹君參與「Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討」研究計畫案，申請本部補助，業經核定以「博士級研究人員」資格補助(MOST 110-2811-B-038-545)，補助項目為研究費、年終獎金、離職儲金、保險費等，請查照。
補助單位
科技部
計畫名稱
110 Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討(2/3)
補助單位
科技部
計畫名稱
110 芳香烴受體於眼科疾病之治療潛力機制探討-芳香烴受體於藍光誘發視網膜病變之治療潛力機制探討(2/3)
補助單位
科技部
計畫名稱
109 蟬花應用於視網膜病變功效性試驗研究計畫
補助單位
葡萄王 生物科技股份有限公司
計畫名稱
109 芳香烴受體於眼科疾病之治療潛力機制探討-芳香烴受體於藍光誘發視網膜病變之治療潛力機制探討(1/3)
補助單位
科技部
計畫名稱
109 Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討(1/3)
補助單位
科技部
計畫名稱
109 補助延攬科技人才印度籍Zuha Imtiyaz Zuha Imtiyaz君參與「Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討」研究計畫案，業經核定以「博士級研究人員」資格補助(MOST 109-2811-B-038-535)，補助項目為研究費、年終獎金、離職儲金、機票費、保險費等，請查照
補助單位
科技部
計畫名稱
108 益康plus產品毒理測試研究計畫
補助單位
寰宇生物科技股份有限公司
計畫名稱
108 探討苯乙醇苷衍生物對於藍光與氧化性物質視黃醛引起視網膜退化之藥理作用機制與視網膜病變之保護療效評估(3/3)
補助單位
科技部
計畫名稱
108 探討一氧化氮奈米載體釋放系統應用於眼腦血管與神經相關之藥理作用機轉與潛在生物效應-探討一氧化氮奈米載體釋放系統於藍光誘發之視網膜病變及相關的藥理或生物效應(3/3)
補助單位
科技部
計畫名稱
107 TRB新型抗體藥物於眼科雷射誘發脈絡膜新生血管試驗
補助單位
三鈺生物科技股份有限公司
計畫名稱
107 探討苯乙醇苷衍生物對於藍光與氧化性物質視黃醛引起視網膜退化之藥理作用機制與視網膜病變之保護療效評估(2/3)
補助單位
科技部
計畫名稱
107 探討一氧化氮奈米載體釋放系統應用於眼腦血管與神經相關之藥理作用機轉與潛在生物效應-探討一氧化氮奈米載體釋放系統於藍光誘發之視網膜病變及相關的藥理或生物效應(2/3)
補助單位
科技部
計畫名稱
106 膠原骨錠健康食品開發研究計畫
補助單位
振翔生物科技有限公司
計畫名稱
106 鹿茸組合物產品之骨質保健 健康食品功效評估
補助單位
立康生物科技股份有限公司
計畫名稱
106 肽康五味子錠健康食品開發研究計畫
補助單位
振翔生物科技有限公司
計畫名稱
106 探討苯乙醇苷衍生物對於藍光與氧化性物質視黃醛引起視網膜退化之藥理作用機制與視網膜病變之保護療效評估(1/3)
補助單位
科技部
計畫名稱
106 探討一氧化氮奈米載體釋放系統應用於眼腦血管與神經相關之藥理作用機轉與潛在生物效應-探討一氧化氮奈米載體釋放系統於藍光誘發之視網膜病變及相關的藥理或生物效應(1/3)
補助單位
科技部
計畫名稱
106 藥學系博士生謝玲珊君擬於107年6月17日至6月20日赴泰國芭達雅參加國際亞洲毒理學會，依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案
補助單位
科技部
計畫名稱
105 VN-BH101調節血糖功效性試驗
補助單位
財團法人生物技術開發中心
計畫名稱
105 偉翔紅樟芝安全性評估病理判定
補助單位
偉翔生技開發股份有限公司
計畫名稱
105 糖順消健康食品之產品開發研究計畫
補助單位
瑞諾華生醫股份有限公司
計畫名稱
105 探討HC-DS合併使用腸泌素相關藥物血糖調節功能性評估研究計畫
補助單位
瑞諾華生醫股份有限公司
計畫名稱
105 金盞花晶亮錠健康食品開發研究計畫
補助單位
宏曄生物科技有限公司
計畫名稱
105 105年10月2日至105年10月6日赴墨西哥美利達(Merida)參加第十四屆國際毒理研討會
補助單位
科技部
計畫名稱
104 杏輝QH活芯升級版軟膠囊之基因毒性及28天動物餵食安全性評估試驗
補助單位
杏輝藥品工業股份有限公司
計畫名稱
104 開發Shikonin 及其衍生物之相關藥理功能: Shikonin 抗老年黃斑病變及促傷口黏膜之癒合作用之機制探討(3/3)
補助單位
科技部
計畫名稱
104 開發Shikonin 及其衍生物之相關藥理功能: Shikonin 抗老年黃斑病變及促傷口黏膜之癒合作用之機制探討(3/3)
補助單位
科技部
計畫名稱
103 104年度「食品衛生安全科學營」
補助單位
衛生福利部食品藥物管理署
計畫名稱
103 104年度「提昇中藥產品品質安全與管制研究類」分項計畫2：中藥製劑使用雄黃安全性評估研究
補助單位
衛生福利部
計畫名稱
103 非傳統及加工食品原料之食用安全性評估
補助單位
衛生福利部食品藥物管理署
計畫名稱
103 開發Shikonin 及其衍生物之相關藥理功能: Shikonin 抗老年黃斑病變及促傷口黏膜之癒合作用之機制探討(2/3)
補助單位
行政院國家科學委員會
計畫名稱
103 天然萃取物HE系列抗460NM波長LED藍光造成人類視網膜上皮離體細胞傷害機制評估暨挪威棕鼠眼睛藥物分布委託計畫
補助單位
杏輝藥品工業股份有限公司
計畫名稱
103 視網膜病變研究計畫
補助單位
杏國新藥股份有限公司
計畫名稱
103 膠原糖胺粉PLUS支基因毒性及28天動物餵時安全性評估試驗
補助單位
振翔生物科技有限公司
計畫名稱
103 聯華食品健康食品諮商研發產學合作計劃
補助單位
聯華食品股份有限公司
計畫名稱
102 非傳統及加工食品原料之安全性評估
補助單位
衛生福利部食品藥物管理署
計畫名稱
102 開發SHIKONIN 及其衍生物之相關藥理功能: SHIKONIN 抗老年黃斑病變及促傷口黏膜之癒合作用之機制探討(1/3)
補助單位
科技部
計畫名稱
102 開發SHIKONIN 及其衍生物之相關藥理功能: SHIKONIN 抗老年黃斑病變及促傷口黏膜之癒合作用之機制探討(2/3)
補助單位
科技部
計畫名稱
102 開發Shikonin 及其衍生物之相關藥理功能: Shikonin 抗老年黃斑病變及促傷口黏膜之癒合作用之機制探討(1/3)
補助單位
行政院國家科學委員會
計畫名稱
102 天然物對RPE細胞損傷保護作用之委託測試
補助單位
杏輝藥品工業股份有限公司
計畫名稱
102 北醫-友華產學研發合作計畫
補助單位
友華生技醫藥股份有限公司
計畫名稱
102 乾式黃斑部病變研究計畫
補助單位
杏國新藥股份有限公司
計畫名稱
101 102年度「非傳統性食品原料安全性評估」委託辦理計畫
補助單位
衛生福利部食品藥物管理署
計畫名稱
101 黑豆健康食品之基因毒性及28天動物餵食安全性評估試驗
補助單位
美梭生技股份有限公司
計畫名稱
101 紐崔萊管花肉蓯蓉錠之基因毒性及28天動物餵食安全性評估試驗
補助單位
安麗日用品股份有限公司
計畫名稱
101 「102年度委託奈米科技研究計畫」-奈米食品管理及其包材容器具之研究
補助單位
衛生福利部食品藥物管理署
計畫名稱
101 Animal Model
補助單位
臺北醫學大學
計畫名稱
101 Tox & animal Model
補助單位
臺北醫學大學
計畫名稱
100 食品添加物及非傳統性食品原料之法規標準與風險評估
補助單位
行政院衛生署食品藥物管理局
計畫名稱
100 奈米食品安全性之研究
補助單位
行政院衛生署食品藥物管理局
計畫名稱
100 探討眼科疾病老年性黃斑部病變之致病機轉及治療藥物之開發: 缺氧蛋白在調節血管新生機制之探討
補助單位
行政院國家科學委員會
計畫名稱
100 Tox and animal studies
補助單位
臺北醫學大學
計畫名稱
99 100年度奈米食品管理機制之研究-分項計畫2-奈米食品原料安全性評估
補助單位
行政院衛生署食品藥物管理局
計畫名稱
99 探討眼科疾病老年性黃斑部病變之致病機轉及治療藥物之開發: 缺氧蛋白在調節血管新生機制之探討
補助單位
行政院國家科學委員會
計畫名稱
98 98年度「特殊營養食品原料及食品添加物安全評估」
補助單位
行政院衛生署
計畫名稱
98 抗癌與抗黏膜潰瘍標靶型HDAC抑制劑之毒性試驗以及活體動物試驗模式之建立
補助單位
臺北醫學大學附設醫院
計畫名稱
98 探討眼科疾病老年性黃斑部病變之致病機轉及治療藥物之開發: 缺氧蛋白在調節血管新生機制之探討
補助單位
行政院國家科學委員會
計畫名稱
98 以5-FU引發潰瘍黏膜建立動物模型進行抗黏膜潰瘍活性測試
補助單位
臺北醫學大學
計畫名稱
96 探討Phenylalkylamine相關結構衍生物抑制人類嗜中性白血球與單核球活化之作用機轉
補助單位
臺北醫學大學附設醫院
計畫名稱
95 探討Resveratrol抑制黴漿菌MALP-2成分刺激人類單核球細胞誘發第九型基質金屬蛋白酵素活化之作用機轉
補助單位
臺北醫學大學附設醫院
計畫名稱
95 氧化膽固醇於血管內皮細胞誘發COX-2 蛋白表現: 氧化膽固醇與癌症形成的關係(1-2)
補助單位
行政院國家科學委員會
計畫名稱
95 氧化膽固醇於血管內皮細胞誘發COX-2 蛋白表現: 氧化膽固醇與癌症形成的關係(2-2)
補助單位
行政院國家科學委員會
計畫名稱
94 氧化性膽固醇促進血管新生及其作用機制之探討
補助單位
行政院國家科學委員會
計畫名稱
93 探討過氧化小體增殖活化接受體致效劑抑制氧化性膽固醇引發細胞凋亡的機轉及對活體氧化性血管傷害之保護作用(2/2)
補助單位
行政院國家科學委員會
計畫名稱
92 探討過氧化小體增殖活化接受體致效劑抑制氧化性膽固醇引發細胞凋亡的機轉及對活體氧化性血管傷害之保護作用(1/2)
補助單位
行政院國家科學委員會
計畫名稱
91 Flavone 類植物成份之藥性開發: Alpha-naphthoflavone 之心血管疾病預防作用及抗癌潛力之研究
補助單位
行政院國家科學委員會
計畫名稱
90 膽固醇氧化物造成血管平滑肌細胞或內皮細胞 apoptosis 機制之探討: MAP kinase 與心血管疾病發生的關係
補助單位
行政院國家科學委員會
計畫名稱
89 藥用植物蘇木降血壓作用之機制探討
補助單位
行政院國家科學委員會