蕭哲志(Hsiao, George) 教授

Email
geohsiao@tmu.edu.tw
現   職
醫學系 副主任
藥理學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立臺灣大學藥理學研究所 博士
1992/09/01~1996/12/01
國立臺灣大學藥理學研究所 碩士
1990/09/01~1992/06/01
私立中國醫藥學院藥學系 學士
1985/10/01~1990/06/01

本校學術經歷

任職單位與職稱[起迄時間]
藥理學科教授
2009/08/01~
藥理學科副教授
2007/08/01~2009/07/31
藥理學研究所副教授
2004/02/01~2007/07/31
藥理學科副教授
2002/08/01~2004/01/31
藥理學科助理教授
1999/08/01~2002/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
眼科學科教授
2023/05/01 ~
國際醫學研究碩士學位學程教授
2019/08/01 ~
國際醫學研究博士學位學程教授
2019/08/01 ~
醫學系副主任
2019/01/01 ~
(舊)生技醫療產業研發博士學位學程教授
2016/08/01 ~ 2017/07/31
藥理學科主任
2014/02/01 ~ 2020/07/31
中草藥臨床藥物研發博士學位學程
2013/08/01 ~
醫學科學研究所副教授
2007/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
國防醫學院助教教官(服兵役)
1998/01/01~1999/05/30
臺灣大學博士後研究
1997/01/01~1997/07/15

專長與研究領域

學門領域
抗氧化與細胞自由基傷害學
發炎及癌症藥理學
藥物對MMP表現與作用之探討
心血管藥理學與藥效評估學
學術專長
Cardiovascular recording and stroke models in vivo
Transfection and Western blotting)
Blood coagulation/platelet aggregation analysis
Spectrophotometric/fluorescence/chemiluminescence analysis techniques
MMP assays
Flow cytometric techniques
Cell culture(vascular cells, monocyte and lymphocyte
Cells,organelles and biomacromolecules preparation
Molecular biological techniques (Flow cytometry, IHC, RT-PCR, Cloning, ChIP)

論文著作

清冊下載


1. 2024 Wu LH,Cheng YW,Lin FL,Hsu KC,Wang MH,「Yen JL, Wang TJ, Lin TE, Liu YC, Huang WJ, Hsiao G」. A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress . Biomed Pharmacother .2024 ;(174):1-17

2. 2023 Sekar P,Hsiao G,Hsu SH,Huang DY,Lin WW,Chan CM. Metformin inhibits methylglyoxal-induced retinal pigment epithelial cell death and retinopathy via AMPK-dependent mechanisms: Reversing mitochondrial dysfunction and upregulating glyoxalase 1 . Redox Biology .2023 ;(64):1-18

3. 2023 Lin FL,Cheng YW,Chen LH,Ho JD,Yen JL,「Wang MH, Lee TH, Hsiao G」. Retinal protection by fungal product theissenolactone B in a sodium iodate-induced AMD model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity . Biomedicine & Pharmacotherapy .2023 ;(156)

4. 2023 Sekar P,Hsiao G,Chen YS,Lin WW,Chan CM. P2X7 Is Involved in the Mouse Retinal Degeneration via the Coordinated Actions in Different Retinal Cell Types . Antioxidants .2023 ;(12)

5. 2023 Chan YJ,Hsiao G,Wan WN,Yang TM,Tsai CH,「Kang JJ, Lee YC, Fang TC, Cheng YW, Li CH」. Blue light exposure collapses the inner blood‑retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17 . Fluids and Barriers of the CNS .2023 ;(20)

6. 2023 Fitriana I,Wu CH,Hsu TJ,Chan YJ,Li CH,「Lee CC, Hsiao G, Cheng YW」. Activation of aryl hydrocarbon receptor by azatyrosine-phenylbutyric hydroxamide inhibits progression of diabetic retinopathy mice . Biochem Pharmacol. .2023 ;(215):1-13

7. 2022 Hsiao G,Chi WC,Chang CH,Chiang YR,Fu YJ,Lee TH. Bioactive pulvinones from a marine algicolous fungus Aspergillus terreus NTU243 . Phytochemistry .2022 ;(200):113229-113236

8. 2021 Hsueh PJ,Wang MH,Hsiao CJ,Chen CK,Lin FL,「Huang SH,Yen JL, Tsai PH, Kuo YH, Hsiao G」. Ergosta-7,9(11),22-trien-3 -ol Alleviates Intracerebral Hemorrhage-Induced Brain Injury and BV-2 Microglial Activation . Molecules .2021 ;(26):1-18

9. 2021 Hsiao SW,Wu YC,Mei HC,Chen YH,Hsiao G,Lee CK. Constituents of Aquilaria sinensis Leaves Upregulate the Expression of Matrix Metalloproteases 2 and 9 . Molecules .2021 ;(26):1-11

10. 2021 Safwan S,Hsiao G,Lee TH,Lee CK. Bioactive compounds from an endophytic fungi Nigrospora aurantiaca . Botanical Studies .2021 ;(62):1-5

11. 2021 Hsieh MH,Hsiao G,Chang CH,Yang YL,Ju YM,「Kuo YH, Lee TH」. Polyketides with Anti-neuroinflammatory Activity from Theissenia cinerea . Journal of Natural Products .2021 ;(84):1898-1903

12. 2021 Hsu TJ,Nepali K,Tsai CH,Imtiyaz Z,Lin FL,「Hsiao G, Lai MJ, Cheng YW」. The HDAC/HSP90 Inhibitor G570 Attenuated Blue Light-Induced Cell Migration in RPE Cells and Neovascularization in Mice through Decreased VEGF Production . Molecules .2021 ;(26):1-19

13. 2020 Hsiao G,Wang SW,Chiang YR,Chi WC,Kuo YH,「Phong DA, Chen CY, Lee TH」. Anti-inflammatory effects of peptides from a marine algicolous fungus Acremonium sp. NTU492 in BV-2 microglial cells . JOURNAL OF FOOD AND DRUG ANANLYSIS .2020 ;(28):283-291

14. 2020 Wang MH,Hsiao G,Al-Shabrawey M. Eicosanoids and oxidative stress in diabetic retinopathy . Antioxidants .2020 ;(9):520

15. 2020 Wang MH,Ibrahim AS,Hsiao G,Tawfik A,Al-Shabrawey M. A novel interaction between soluble epoxide hydrolase and the AT1 receptor in retinal microvascular damage . Prostaglandins Other Lipid Mediat. .2020 ;(148):106449

16. 2019 Fan-Li Lin,Yu-Wen Cheng,Min Yu,Jau-Der Ho,Yu-Cheng Kuo,「George C.Y. Chiou, Hung-Ming Change, Tzong-Huei Lee, George Hsiao」. The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition . Phytomedicine .2019 ;(56):207-214

17. 2019 Lin CH,Wu MR,Huang WJ,Chow DS,Hsiao G,Cheng YW. Low-Luminance Blue Light-Enhanced Phototoxicity in A2E-Laden RPE Cell Cultures and Rats. . Int J Mol Sci .2019 ;(20):1-19

18. 2019 Lin FL,Yen JL,Kuo YC,Kang JJ,Cheng YW ,「Huang WJ,Hsiao G」. HADC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-Induced Mouse Model of Neuroinflammation and Microglial Activation . Int J Mol Sci .2019 ;(20):1-20

19. 2019 Jan JS,Yang CH,Wang MH,Lin FL,Yen JL,「Hsieh I, Khotimchenko M, Lee TH, Hsiao G」. Hirsutanol A Attenuates Lipopolysaccharide-Mediated Matrix Metalloproteinase 9 Expression and Cytokines Production and Improves Endotoxemia-Induced Acute Sickness Behavior and Acute Lung Injury . Mar Drugs .2019 ;(17):E360-E369

20. 2018 「Lin FL」,「Ho JD」,「Cheng YW」,「Chiou GCY」,「Yen JL」,「Chang HM,Lee TH,Hsiao G」. Theissenolactone C exhibited ocular protection of endotoxin-induced uveitis by attenuating ocular inflammatory responses and glial activation . Fronteirs in Pharmacology .2018 ;(9):326-340

21. 2018 Lee YL,Hsiao CJ,Lin FL,Jan JS,Chou YC,「Lin YY,Chen CK,Lam KK,Hsiao G」. Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells . Mediators of Inflammation .2018 ;(2018):9541459-9541459

22. 2017 「Hsiao G」,「Chi WC」,「Pang KL」,「Chen JJ」,「Kuo YH」,「Wang YK, Cha HJ, Chou SC, Lee TH」. Hirsutane-Type Sesquiterpenes with Inhibitory Activity of Microglial Nitric Oxide Production from the Red Alga-Derived Fungus Chondrostereum sp. NTOU4196. . J Nat Prod. .2017 ;(80):1615-1622

23. 2017 Jan JS,Chou YC,Cheng YW,Chen CK,Huang WJ,Hsiao G. The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo. . Int J Mol Sci. .2017 ;(18):1-20

24. 2017 Chen LY,Renn TY,Liao WC,Mai FD,Ho YJ,「Hsiao G, Lee AW, Chang HM」. Melatonin successfully rescues hippocampal bioenergetics and improves cognitive function following drug intoxication by promoting Nrf2-ARE signaling activity . J Pineal Res .2017 ;(63)

25. 2017 Lin FL,Lin CH,Ho JD,Yen JL,Chang HM,「Chiou GC, Cheng YW, Hsiao G」. The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration . Scientifif Report .2017 ;(7):1-13

26. 2017 Lin CH,Wu MR,Li CH,Cheng HW,Huang SH,「Tsai CH, Lin FL, Ho JD, Kang JJ, Hsiao G, Cheng YW」. Periodic exposure to smatphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis . Toxicol Sci. .2017

27. 2017 Chang JC,Hsiao G,Lin RK,Kuo YH,Ju YM,Lee TH. Bioactive constituents from the termite nest-derived medicinal fungus Xylaria nigripes . J Nat Prod .2017 ;(80):38-44

28. 2017 HuangFu WC,Chao MW,Cheng CC,Wei YC,Wu YW,「Liou JP, Hsiao G, Lee YC, Yang CR」. Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo . Scientifif Report .2017 ;(7):42291

29. 2017 Hsu W,Mercado AT,Hsiao G,Yeh JM,Chen CY. Detection and discrimination of maintenance and de novo CpG methylation events using methylbreak . Biosens Bioelectron .2017 ;(91):658-663

30. 2016 Lee CH,Hsu CC,Hsiao G,Fang JY,Liu WM,Lee CK. Anti-MMP-2 activity and skin-penetrating capability of the chemical constituents from Rhodiola rosea . Planta Med. .2016 ;(82):698-704

31. 2016 Lin CL,Hsiao G,Wang CC,Lee YL. Imperatorin exerts antiallergic effects in Th2-mediated allergic asthma via induction of IL-10-producing regulatory T cells by modulating the function of dendritic cells . Pharmacol Res .2016 ;(110):111-121

32. 2015 Chen WL,Sheu JR,Chen RJ,Hsiao SH,Hsiao CJ,「Chou YC, Chung CL, Hsiao G」. Mycobacterium tuberculosis Upregulates TNF-α Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells. . PLOSone .2015 ;(10):1-16

33. 2015 Lin CH,Liao PL,Hsiao G,Li CH,Huang SH,「Tsai CH,Wu MR, Lin FL, Ho JD, Cheng HW, Cheng YW」. Long-term fluorometholone topical use induces ganglion cell damage in rats analyzed with optical coherence tomography . Toxicol Sci .2015 ;(147):317-325

34. 2014 Wang CH,Hsiao CJ,Lin YN,Wu JW,Kuo YC,「Lee CK,Hsiao G」. Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells . Pharm Biol .2014 ;(52):1451-1459

35. 2014 Wang CL,Lee O,Hsiao G,Lian JF,Cheng YW. Novel piperazinediones as antitumor agents. . Anticancer Res .2014 ;(34):4013-4019

36. 2014 Jian WS,Huang CL,Iqbal U,Nguyen PA,Hsiao G,「Li HC」. How did national life expectation related to school years in developing countries - an approach using panel data mining. . Comput Methods Programs Biomed .2014 ;(113):914-918

37. 2014 Chen WL,Sheu JR,Hsiao CJ,Hsiao SH,Chung CL,「Hsiao G」. Histone Deacetylase Inhibitor Impairs Plasminogen Activator Inhibitor-1 Expression via Inhibiting TNF- α -Activated MAPK/AP-1 Signaling Cascade. . Biomed Res Int .2014 ;(2014):231012

38. 2014 Hsiao CJ,Hsiao G,Chen WL,Wang SW,Chiang CP,「Liu LY, Guh JH, Lee TH, Chung CL」. Cephalochromin induces g0/g1 cell cycle arrest and apoptosis in a549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption. . J Nat Prod .2014 ;(77):758-765

39. 2014 Hsieh CY,Hsiao G,Hsu MJ,Wang YH,Sheu JR. PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth muscle cells. . J Cell Mol Med .2014 ;(18):1278-1289

40. 2013 Huang HM,Hsiao G,Fan CK,Lin CL,Leu SJ,「Chiang BL,Lee YL」. Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production. . PLoS One .2013 ;(8):e6363

41. 2013 Yung-Chang Lu,George Hsiao,Kuan-Hung Lin,Ming-Shium Hsieh,Thanasekaran Jayakum,「Tian-Shung Wu1,Joen-Rong Sheu」. Cinnamophilin Isolated from Cinnamomum philippinense Protects against Collagen Degradation in Human Chondrocytes . PHYTOTHERAPY RESEARCH .2013 ;(27):892-899

42. 2013 Wang JJ,Huan SK,Hsieh KH,Chou HC,Hsiao G,「Jayakumar T, Sheu JR」. Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling. . Arch Med Sci .2013 ;(9):332-339

43. 2013 Jayakumar T,Chen WF,Lu WJ,Chou DS,Hsiao G,「Hsu CY, Sheu JR, Hsieh CY」. A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies. . J Nutr Biochem .2013 ;(24):1086-1095

44. 2013 Lee YL,Lee LW,Su CY,Hsiao G,Yang YY,「Leu SJ, Shieh YH, Burnouf T」. Virally inactivated human platelet concentrate lysate induces regulatory T cells and immunosuppressive effect in a murine asthma model. . Transfusion .2013 ;(53):1918-1928

45. 2013 Chung CL,Hsiao SH,Hsiao G,Sheu JR,Chen WL,「Chang SC」. Clinical importance of angiogenic cytokines, fibrinolytic activity and effusion size in parapneumonic effusions. . PLoS One .2013 ;(8):e53169

46. 2012 Chung CL,Sheu JR,Chen WL,Chou YC,Hsiao CJ,Hsiao SH, Hsu MJ, Cheng YW, Hsiao G. Histone Deacetylase Inhibitor CBHA Attenuates PAI-1 Expression in Human Pleural Mesothelial Cells. . Am J Respir Cell Mol Biol. .2012 ;(46):437-445

47. 2012 Lee WR,Chung CL,Hsiao CJ,Chou YC,Hsueh PJ,「Yang PC,Jan JS,Cheng YW,Hsiao G」. Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation . Phytomedicine .2012 ;(19):270-277

48. 2012 Lu YC,Hsiao G,Lin KH,Hsieh MS,Jayakumar T,「Wu TS, Sheu JR」. Cinnamophilin Isolated from Cinnamomum philippinense Protects against Collagen Degradation in Human Chondrocytes . Phytother Res.2012 .2012 ;(Epub)

49. 2012 Lu WJ,Lin KH,Hsu MJ,Chou DS,Hsiao G,「Sheu JR」. Suppression of NF-kB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade . Biochem Pharmacol. .2012 ;(84):914-924

50. 2012 Su TR,Zei WS,Su CC,Hsiao G,Lin MJ. The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker . Evid Based Complement Alternat Med. .2012 ;(Epub)

51. 2012 Hsiao CJ,Hsiao SH,Chen WL,Guh JH,Hsiao G,「Chan YJ, Lee TH, Chung CL」. Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells . Chem Biol Interact. .2012 ;(197):23-30

52. 2011 Hsieh CY,Hsu MJ,Hsiao G,Wang YH,Huang CW,「Chen SW, Jayakumar T, Chiu PT, Chiu TH, Sheu JR」. Andrographolide enhances NF-kB subunit p65 ser536 dephosphorylation through activation of protein phosphatase 2A (PP2A) in vascular smooth muscle cells . J Biol Chem .2011 ;(286):5942-5955

53. 2011 Chou YC,Sheu JR,Chung CL,Hsiao CJ,Hsueh PJ,Hsiao G. Hypertonicity-enhanced TNF-a release from activated human monocytic THP-1 cells requires ERK activation . BBA .2011 ;(1810):475-484

54. 2011 Wu CJ,Chou YC,Cheng YW,Hsiao CJ,Wang CH,「Wang HY,Sheu JR, Hsiao G」. Aristolochic acid downregulates monocytic matrix metalloproteinase-9 by inhibiting nuclear factor-κB activation. . Chem Biol Interact. 2011 Mar 29; 192:209-219 .2011 ;(192):209-219

55. 2011 Lu YC,Jayakumar T,DuannYF,Chou YC,Hsieh CY,「Yu SY, Sheu JR, Hsiao G」. Chondroprotective Role of Sesamol by Inhibiting MMPs Expression via Retaining NF-κB Signaling in Activated SW1353 Cells. . J Agric Food Chem. .2011 ;(59):4969-4978

56. 2010 Chou YC,Sheu JR,Chung CL,Chen CY,Lin FL,Hsu MJ, Kuo YH, Hsiao G. Nuclear-Targeted Inhibition of NF-κB on MMP-9 Production by N-2-(4-Bromophenyl) Ethyl Caffeamide in Human Monocytic Cells . Chemico-Biological Interactions .2010 ;(184):403-412

57. 2009 Chou DS,Hsiao G,Lai YA,Tsai YJ,Sheu JR. Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase . Free Radical Biology and Medicine .2009 ;(46):1197-1203

58. 2009 Chung CL,Sheu JR,Liu HE,Chang SC,Chou YC,「Chen WL, Chou DS, Hsiao G」. Dynasore, a dynamin inhibitor, induces PAI-1 expression in Met-5A human pleural mesothelial cells . Am J Respir Cell Mol Biol .2009 ;(40):692-700

59. 2009 Lin KH,Hsiao G,Shih CM,Chou DS,Sheu JR. Mechanisms of resveratrol-induced platelet apoptosis. . Cardiovasc Res. .2009 ;(83):575-585

60. 2008 Shen MY,Hsiao G,Fong TH,Chou DS,Sheu JR. Expression of amyloid beta peptide in human plateletys: pivotal role of the phospholipase Cgamma2 protein kinase C pathway in platelet activation . Pharmacol Res .2008 ;(57):151-158

61. 2008 Shen MY,Hsiao G,Fong TH,Chen HM,Chou DS,「Lin CH, Sheu JR, Hsu CY」. Amyloid beta peptide-activated signal pathways in human platelets . Eur J Pharmacol .2008 ;(588):259-266

62. 2008 Shen MY,Liu CL,Hsiao G,LiuCY,Lin KH,「Chou DS, Sheu JR」. Involvement of p38 MAPK phosphorylation and nitrate formation in aristolochic acid-mediated antiplatelet activity . Planta Med .2008 ;(74):1240-1245

63. 2007 Hsiao G,Lee JJ,Lin KH,Shen CH,Fong TH,「Chou DS, Sheu JR」. Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in vitro and in vivo studies . Cardiovasc Res .2007 ;(75):782-792

64. 2007 Shen MY,Hsiao G,Liu CL,Fong TH,Lin KH,「Chou DS, Sheu JR」. Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cGMP . Br J Haematol .2007 ;(139):475-485

65. 2007 Chang Y,Hsiao G,Chen SH,Chen YC,Lin JH,「Lin KH, Chou DS, Sheu JR」. Tetramethylpyrazine suppresses HIF-1 alpha, TNF-alpha, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats . Acta Pharmacol Sin .2007 ;(28):327-333

66. 2007 Hsiao G,Lee JJ,Chen YC,Lin JH,Shen MY,「Lin KH,Chou DS, Sheu JR」. Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions . Biochem Pharmacol .2007 ;(73):682-693

67. 2006 Hsiao G,Chen YC,Lin JH,Lin KH,Chou DS,「Lin CH,Sheu JR」. Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats . Planta Med .2006 ;(72):411-417

68. 2006 Lam KK,Lee YM,Hsiao G,Chen SY,Yen MH. Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats. . Menopause .2006 ;(13):294-302

69. 2005 Chen SP,Sheu JR,Lai CY,Lin TY,Hsiao G,Fong TH. Detection of myofibrillar proteins using a step gradient minigel with an ambiguous interface. . Anal Biochem. .2005 ;(338):270-277

70. 2005 Chou DS,Hsiao G,Shen MY,Tsai YJ,Chen TF,Sheu JR. ESR spin trapping of a carbon-centered free radical from agonist-stimulated human platelets. . Free Radic Biol Med. .2005 ;(39):237-248

71. 2005 Hsiao G,Chang CY,Shen MY,Chou DS,Tzeng SH,Chen TF, Sheu JR. alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation. . J Agric Food Chem .2005 ;(53):5179-5186

72. 2005 Hsiao G,Lin KH,Chang Y,Chen TL,Tzu NH,Chou DS, Sheu JR. Protective mechanisms of inosine in platelet activation and cerebral ischemic damage. . Arterioscler Thromb Vasc Biol .2005 ;(25):1998-2004

73. 2005 Chen SP,Sheu JR,Lin AC,Hsiao G,Fong TH. Decline in titin content in rat skeletal muscle after denervation. . Muscle Nerve .2005 ;(32):798-807

74. 2005 Hsiao G,Chou PH,Shen MY,Chou DS,Lin CH,Sheu JR. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. . J Agric Food Chem .2005 ;(53):7734-7740

75. 2005 Hsiao G,Wang Y,Tzu NH,Fong TH,Shen MY,Lin KH, Chou DS, Sheu JR. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. . J Lab Clin Med .2005 ;(146):216-226

76. 2005 Chou DS,Chan CH,Hsiao G,Shen MY,Tsai YJ,Chen TF, Sheu JR. Inhibitory mechanisms of low concentration of oxidized low-density lipoprotein on platelet aggregation. . J Biomed Sci .2005

77. 2005 Hsiao G,Chen YC,Lin JH,Lin KH,Chou DS,Lin CH, Sheu JR. Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats . Planta Medica .2005

78. 2004 Chen JH,Hsiao G,Lee AR,Wu CC,Yen MH. Andrographolide suppresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase/Akt pathway . Biochem Pharmacol .2004 ;(67):1337-1345

79. 2004 Hsiao G,Shen MY,Chou DS,Chang Y,Lee LW,Sheu JR. Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies . Eur J Pharmacol. .2004 ;(487):159-166

80. 2004 Hsiao G,Shen MY,Chou DS,Lin CH,Chen TF,Sheu JR. Involvement of the antiplatelet activity of magnesium sulfate in suppression of protein kinase C and the Na+/H+ exchanger. . J Biomed Sci .2004 ;(11):19-26

81. 2004 Sheu JR,,Hsiao G,,Chou PH,Shen MY,Chou DS. Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. . J Agric Food Chem. .2004 ;(52):4414-4418

82. 2004 Hsiao G,,Fong TH,,Tzu NH,Lin KH,Chou DS,Sheu JR. A potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats. . In Vivo .2004 ;(18):351-356

83. 2004 Chou DS,,Hsiao G,,Shen MY,Fong TH,Lin CH,Chen TF, Sheu JR.. Low concentration of oxidized low density lipoprotein suppresses platelet reactivity in vitro: an intracellular study . Lipids .2004 ;(39):433-440

84. 2004 Sheu JR,Fong TH,Liu CM,,Shen MY,Chen TL,,Chang Y, Lu MS, Hsiao G.. Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies. . Br J Pharmacol. .2004 ;(143):193-201

85. 2004 Chang Y,Chen TL,Wu GJ,Hsiao G,Shen MY,Lin KH, Chou DS, Lin CH, Sheu JR. Mechanisms involved in the antiplatelet activity of ketamine in human platelets . J Biomed Sci. .2004 ;(11):764-772

86. 2004 Hsiao G,Huang HY,Fong TH,Shen MY,Lin CH,Teng CM, Sheu JR. Inhibitory mechanisms of YC-1 and PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages . Biochemical Pharmacology .2004 ;(67):1411-1419

87. 2003 Chuang WJ, Wu CH, Huang HN, Chen SH, Hsiao G, Lin CH, Sheu JR. Comparison of the binding character of triflavin on resting and activated alpha(IIb)beta(3) integrin in human platelets by electron microscopy. . Thromb Res. .2003 ;(109):37-46

88. 2003 Hsiao G, Shen MY, Chang WC, Cheng YW, Pan SL, Kuo YH, Chen TF, Sheu JR.. A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells. . Biochem Pharmacol. .2003 ;(65):1383-1392

89. 2003 Hsiao G, Shen MY, Lin KH, Chou CY, Tzu NH, Lin CH, Chou DS, Chen TF, Sheu JR.. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. . Eur J Pharmacol. .2003 ;(465):281-287

90. 2003 Hsiao G, Shen MY, Fang CL, Chou DS, Lin CH, Chen TF, Sheu JR. Morphine-potentiated platelet aggregation in in vitro and platelet plug formation in in vivo experiments. . J Biomed Sci. .2003 ;(10):292-301

91. 2003 Hsiao G, Shen MY, Lin KH, Lan MH, Wu LY, Chou DS, Lin CH, Su CH, Sheu JR.. Antioxidative and hepatoprotective effects of Antrodia camphorata extract. . J Agric Food Chem. .2003 ;(51):3302-3308

92. 2003 Sheu JR, Hsiao G, Shen MY, Lee YM, Yen MH.. Antithrombotic effects of magnesium sulfate in in vivo experiments. . Int J Hematol. .2003 ;(77):414-419

93. 2003 Sheu JR, Hsiao G, Shen MY, Chou CY, Lin CH, Chen TF, Chou DS.. Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation. . Platelets. .2003 ;(14):189-196

94. 2003 Chen JH, Wu CC, Hsiao G, Yen MH.. Magnolol induces apoptosis in vascular smooth muscle. . Naunyn Schmiedebergs Arch Pharmacol. .2003 ;(368):127-133

95. 2003 Lee YM, Hsiao G, Chang JW, Sheu JR, Yen MH.. Scoparone inhibits tissue factor expression in lipopolysaccharide-activated human umbilical vein endothelial cells. . J Biomed Sci. .2003 ;(10):518-525

96. 2003 Sheu JR,,Hsiao G,Shen MY,,Wang Y,Lin KH,,Lin CH, Sheu JR. Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments. . Exp Biol Med (Maywood). .2003 ;(228):1321-1328

97. 2002 Hsiao G, Yen MH, Lee YM and Sheu JR. Antithrombotic effect of PMC, a potent a-tocopherol analogue on platelet plug formation . Br. J. Haemotol. .2002 ;(117):1-6

98. 2002 Lee YM, Chen HR, Hsiao G, Sheu JR, Wang JJ and Yen MH. Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo . J. Pineal Res. .2002 ;(32):1-9

99. 2002 Sheu JR, Hsiao G, Luk HN, Chen YW, Chen TL, Lee LW, Lin CH and Chou DS. Mechanisms involved in the antiplatelet activity of midazolam in human platelet . Anesthesiology .2002 ;(96):651-658

100. 2001 George Hsiao, Yun-Ho Lin, Chien-Huang Lin, Duen-Suey Chou and Joen-Rong Sheu. The protective effects of PMC against chronic carbon tetrachloride-induced hepatotoxicity in vivo ( 2001, in press ) . Biological Pharmaceutical Bulletin .2001 ;(24):1271-1276

101. 2001 Hong HJ, Hsiao G, Cheng TH and Yen MH. Supplementation with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats . Hypertension .2001 ;(38):1044-1048

102. 2001 Hsiao G, Chou DS, Wu TC, Shen MY and Sheu JR. Role of metallothionein in free radical-scavenging and cytoprotective activities . New Taipei Journal of Medicine .2001 ;(73):393-398

103. 2001 Duen-Suey Chou, George Hsiao, Tzeng-Fu Chen, Joen-Rong Sheu. Mechanism involved in methylene blue-induced tension changes in isolated guinea pig trachea . New Taipei Journal of Medicine .2001 ;(3):18-25

104. 2001 G Hsiao, CM Teng, JR Sheu, YW Cheng, KK Lam, YM Lee, TS Wu and MH Yen. Cinnamophilin as a novel antiperoxidative cytoprotectant and free redical scavenger . Biochimica et Biophysica Acta .2001 ;(1525):77-88

105. 2001 Yen-Mei Lee, George Hsiao, Huey-Rue Chen, Yao-Chang Chen, Joen-Rong Sheu, Mao-Hsiung Yen. Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats . European Journal of Pharmacology .2001 ;(422):159-167

106. 2001 Joen R. Sheu, George Hsiao, Yen M. Lee, Mao H. Yen. Antithrombotic effects of tetramethylpyrazine in in vivo experiments . International Journal of Hematology .2001 ;(73):393-398

107. 2001 Ching-Hsiang Wu, Yi-Chun Chen, George Hsiao, Chien-Huang Lin, Cheng-Ming Liu and Joen-Rong Sheu. Mechanisms involved in the inhibition of neointimal hyperplasia by abciximab in a rat model of balloon angioplasty . Thrombosis Research .2001 ;(101):127-138

108. 2001 Wu CC, Chiao CW, Hsiao G, Chen A, Yen MH. Melatonin prevents endotoxin-induced circulatory failure in rats . Journal of Pineal Research .2001 ;(30):147-156

109. 2000 Joen-Rong Sheu, Cheng-Rong Lee, Chein-Huang Lin, George Hsiao, Wun-Chang Ko, Yao-Chang Chen, Mao-Hsiung Yen. Mechanism Involved in the Antiplatelet Activity of Staphylococcus aureus Lipoteichoic Acid in Human Platelet . Thrombosis and Haemostasis .2000 ;(83):777-784

110. 2000 Joen-Rong Sheu, George Hsiao, Cheng-Rong Lee, Wen-Chiung Chang, Ling-Wen Lee, Ching-Hua Su and Chien-Huang Lin. Antiplatelet activity of Staphylococcus aureus lipoteichoic acid is mediated through a cyclic AMP pathway . Thrombosis Research .2000 ;(99):249-258

111. 1999 Sheu JR, Lee CR, Hsiao G, Hung WC, Lee YM, Chen YC and Yen MH. Comparison of the relative activities of a-tocopherol and PMC on platelet aggregation and antioxidative activity. . Life Sciences .1999 ;(65):197-206

112. 1998 Hsiao G, Ko FN, Jong TT and Teng CM. Antiplatelet action of 3' ,4' -diisovalerylkhellactone diester purified from Peucedanum japonicum Thunb. . Biological & Pharmaceutical Bulletin .1998 ;(21):688-692

113. 1997 Ko FN, Hsiao LG and Kuo YH. Protection of oxidative hemolysis by demethyldiisoeugenol in normal and β-thalassemic red blood cells. . Free Radical Biology and Medicine .1997 ;(22):215-222

114. 1996 Hsiao G, Ko FN, Lin CN and Teng CM. Antioxidant properties of isotorachrysone isolated from Rhamnus nakaharai. . Biochimica et Biophysica Acta .1996 ;(1298):119-130

115. 1996 Hsiao G, Teng CM, Wu CL and Ko FN. Marchantin H as a natural antioxidant and free radical scavenger. . Archives of Biochemistry and Biophysics .1996 ;(334):18-26

116. 1996 Teng CM, Hsiao G, Ko FN, Lin DT and Lee SS. N-Allylsecoboldine as a novel antioxidant against peroxidative damage. . European Journal of Pharmacology .1996 ;(303):129-139

研究計畫

計畫名稱
113 探討中藥抗發炎成分改善眼科疾病之視網膜與跨神經元退化性損傷的作用機制及其療效特性(1/3)
補助單位
國家科學及技術委員會

計畫名稱
113 攬沈彥丞君參與「探討中藥抗發炎成分改善眼科疾病之視網膜與跨神經元退化性損傷的 作用機制及其療效特性」研究計畫案,申請本會補助,業經核定以「博士級研究人員」資格補助 (NSTC 113-2811-B-038-008)
補助單位
國家科學及技術委員會

計畫名稱
112 探討具調節STAT訊息之真菌成分在視網膜穆勒及小神經膠細胞作用機制及其改善青光眼誘發神經性退化之療效(3/3)
補助單位
國家科學及技術委員會

計畫名稱
112 延攬沈彥丞君參與「探討具調節STAT訊息之真菌成分在視網膜穆勒及小神經膠細胞作用機制及其改善青光眼誘發神經性退化之療效」研究計畫案,申請本會補助,業經核定以「博士級研究人員」資格補助(NSTC 112-2811-B-038-062)
補助單位
國家科學及技術委員會

計畫名稱
111 探討治療視網膜之中藥成分對視網膜穆勒細胞活化與非高眼壓型青光眼之療效作用機制
補助單位
國家科學及技術委員會

計畫名稱
111 藥理學科隨專題研究計畫蕭哲志醫學系副主任申請補助延攬科技人才林凡立君參與「探討具調節STAT訊息之真菌成分在視網膜穆勒及小神經膠細胞作用機制及其改善青光眼誘發神經性退化之療效」研究計畫案,業經核定以「博士級研究人員」資格補助(MOST 110-2811-B-038-506-MY3)
補助單位
國家科學及技術委員會

計畫名稱
111 探討具調節STAT訊息之真菌成分在視網膜穆勒及小神經膠細胞作用機制及其改善青光眼誘發神經性退化之療效(2/3)
補助單位
國家科學及技術委員會

計畫名稱
111 延攬科技人才林凡立君參與「探討具調節STAT訊息之真菌成分在視網膜穆勒及小神經膠細胞作用機制及其改善青光眼誘發神經性退化之療效」
補助單位
國家科學及技術委員會

計畫名稱
111 芳香烴受體於眼科疾病之治療潛力機制探討-探討芳香烴受體活化在青光眼病程的視網膜保護角色(3/3)
補助單位
國家科學及技術委員會

計畫名稱
110 探討具調節STAT訊息之真菌成分在視網膜穆勒及小神經膠細胞作用機制及其改善青光眼誘發神經性退化之療效(1/3)
補助單位
科技部

計畫名稱
110 芳香烴受體於眼科疾病之治療潛力機制探討-探討芳香烴受體活化在青光眼病程的視網膜保護角色(2/3)
補助單位
科技部

計畫名稱
110 延攬科技人才林凡立君參與「探討具調節STAT訊息之真菌成分在視網膜穆勒及小神經膠細胞作用機制及其改善青光眼誘發神經性退化之療效」
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科技部

計畫名稱
109 探討真菌天然物成分HMH-1-80-3抑制小神經膠質細胞之活化機制及對內毒素誘發腦部發炎之療效評估
補助單位
科技部

計畫名稱
109 探討真菌衍生之抗神經發炎成分及其對視網膜疾病之療效評估(3/3)
補助單位
科技部

計畫名稱
109 芳香烴受體於眼科疾病之治療潛力機制探討-探討芳香烴受體活化在青光眼病程的視網膜保護角色(1/3)
補助單位
科技部

計畫名稱
108 BMX藥物於眼科雷射誘發脈絡膜新生血管試驗研究計畫
補助單位
彥臣生技藥品股份有限公司

計畫名稱
108 探討真菌衍生之抗神經發炎成分及其對視網膜疾病之療效評估(2/3)
補助單位
科技部

計畫名稱
107 探討真菌衍生之抗神經發炎成分及其對視網膜疾病之療效評估(1/3)
補助單位
科技部

計畫名稱
106 探討新型雙效HSP及HDAC抑制藥物在視網膜疾病之治療作用
補助單位
科技部

計畫名稱
106 胜肽藥物於眼科雷射誘發脈絡膜新生血管(完整版)
補助單位
艾斯克立必恩股份有限公司

計畫名稱
106 胜肽藥物於眼科雷射誘發脈絡膜新生血管試驗
補助單位
財團法人生物技術開發中心

計畫名稱
106 醫學科學研究所博士生詹景勛君擬於107年7月1日至7月6日赴日本京都參加第18屆世界基礎與臨床藥理學大會,依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案
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科技部

計畫名稱
105 開發BMX為治療視網膜血管新生藥物研究計畫
補助單位
彥臣生技股份有限公司

計畫名稱
105 探討多元TAK1/TABs調節成分抑制小神經膠及巨噬細胞活化機制及其對腦內出血與腦膿瘍之保護療效評估
補助單位

計畫名稱
104 探討不同選擇作用之組織蛋白去乙醯?調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估-林承輝
補助單位
科技部

計畫名稱
104 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(3/3)
補助單位
科技部

計畫名稱
104 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(3/3)
補助單位
科技部

計畫名稱
103 偉翔紅樟芝之大鼠90天口服重覆劑量毒性試驗
補助單位
偉翔生技開發股份有限公司

計畫名稱
103 探討不同選擇作用之組織蛋白去乙醯 掤調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估-周泳臣(博)
補助單位
科技部

計畫名稱
103 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(2/3)
補助單位
行政院國家科學委員會

計畫名稱
102 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(1/3)
補助單位
行政院國家科學委員會

計畫名稱
102 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(1-3)
補助單位
科技部

計畫名稱
102 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(2-3)
補助單位
科技部

計畫名稱
102 探討不同選擇作用之組織蛋白去乙醯 掤調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估-周泳臣(博)
補助單位
科技部

計畫名稱
101 探討具有調節氧化還原作用之生物活性成分對發炎基因表現之抑制性機轉及其對實驗性腦部中風之保護效能
補助單位
行政院國家科學委員會

計畫名稱
101 Pharmacology
補助單位
臺北醫學大學

計畫名稱
101 PD/PK & Pharmacology
補助單位
臺北醫學大學

計畫名稱
100 乳酸菌植物萃取AMS取代傳統化學防腐劑的新產品開發:毒理試驗及安定性分析
補助單位
國強生技股份有限公司

計畫名稱
100 探討具有調節氧化還原作用之生物活性成分對發炎基因表現之抑制性機轉及其對實驗性腦部中風之保護效能
補助單位
行政院國家科學委員會

計畫名稱
100 Pharmacology
補助單位
臺北醫學大學

計畫名稱
99 探討具有調節氧化還原作用之生物活性成分對發炎基因表現之抑制性機轉及其對實驗性腦部中風之保護效能
補助單位
行政院國家科學委員會

計畫名稱
98 探討caffeic acid phenethyl ester抑制小神經膠細胞發炎介質表現之機轉並評估其對活體阻塞性腦中風動物之保護作用
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
98 探討創傷性腦損傷中mTOR與HIF-1 alpha在發炎基因表現之角色
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
98 探討Indene相關結構衍生物抑制基質金屬蛋白酵素表現與血管放鬆之機轉並評估其對活體出血性腦中風動物之保護作用
補助單位
行政院國家科學委員會

計畫名稱
97 探討Indene相關結構衍生物抑制基質金屬蛋白酵素表現與血管放鬆之機轉並評估其對活體出血性腦中風動物之保護作用
補助單位
行政院國家科學委員會

計畫名稱
96 探討Indene相關結構衍生物抑制基質金屬蛋白酵素表現與血管放鬆之機轉並評估其對活體出血性腦中風動物之保護作用(1-3)
補助單位
行政院國家科學委員會

計畫名稱
95 提昇私校研發能量專案計畫-探討氧化態低密度脂蛋白在中風疾病過程所扮演的病理角色-子計畫四:探討JAK-STAT在氧化態低密度脂蛋白活化小神經膠細胞的訊息角色及不同氧化程度低密度脂蛋白引起與加強腦中風傷害的差異性比較(3-3)
補助單位
行政院國家科學委員會

計畫名稱
94 探討Haloperidol抑制單核球與小神經膠細胞誘發基質金屬蛋白酵素活化的作用機轉及其對大鼠蜘蛛網膜下腔出血後之保護作用評估
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理

計畫名稱
94 探討haloperidol抑制單核球與小神經膠細胞誘發基質金屬蛋白酵素活化之作用機轉及其對大鼠蜘蛛網膜下腔出血後之保護作用評估
補助單位
行政院國家科學委員會

計畫名稱
94 提昇私校研發能量專案計畫-探討氧化態低密度脂蛋白在中風疾病過程所扮演的病理角色-子計畫四:探討JAK-STAT在氧化態低密度脂蛋白活化小神經膠細胞的訊息角色及不同氧化程度低密度脂蛋白引起與加強腦中風傷害的差異性
補助單位
行政院國家科學委員會

計畫名稱
93 探討不同抗巨噬單核球細胞之藥物對基質金屬蛋白酵素活化之抑制機轉與比較其對革蘭氏陽性與陰性菌所造成多重器官衰竭之保護作用
補助單位
行政院國家科學委員會

計畫名稱
93 提昇私校研發能量專案計畫-探討氧化態低密度脂蛋白在中風疾病過程所扮演的病理角色-子計畫四:探討JAK-STAT在氧化態低密度脂蛋白活化小神經膠細胞的訊息角色及不同氧化程度低密度脂蛋白引起與加強腦中風傷害的差異性
補助單位
行政院國家科學委員會

計畫名稱
93 探討Pyrrolidine dithiocarbamate影響人類臍帶靜脈內皮細胞株與初級細胞對基質金屬蛋白酵素活化的作用與機轉差異
補助單位
新光醫療財團法人新光吳火獅紀念醫院

計畫名稱
92 黃芩素與馬兜鈴酸影響腎臟環間膜與單核球細胞表現基質金屬蛋白酵素活性之機轉探討  
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財團法人台灣基督長老教會馬偕紀念社會事業基金會馬偕紀念醫院

計畫名稱
92 探討抑制人類白血球誘發基質金屬蛋白酵素活化之藥物機轉及其對活體再甦醒性傷害的保護作用之評估(1/2)
補助單位
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